Errfi1 ERBB receptor feedback inhibitor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Errfi1provided by MGI
Official Full Name: ERBB receptor feedback inhibitor 1provided by MGI
Primary source: MGI:MGI:1921405
See related: Ensembl:ENSMUSG00000028967 AllianceGenome:MGI:1921405
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mig6; RALT; Mig-6; 1300002F13Rik
Summary: Predicted to enable SH3 domain binding activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including lung development; negative regulation of epidermal growth factor-activated receptor activity; and skin morphogenesis. Acts upstream of or within several processes, including bile acid biosynthetic process; intracellular signal transduction; and regulation of protein kinase activity. Located in cytoplasm and plasma membrane. Is expressed in alveolar system; lung; and lung epithelium. Used to study endometrial cancer and osteoarthritis. Orthologous to human ERRFI1 (ERBB receptor feedback inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver adult (RPKM 96.9), kidney adult (RPKM 81.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 81.5 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (150938253..150953346)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (150853796..150868889)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner.
Title: ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner.
Loss of MIG-6 results in endometrial progesterone resistance via ERBB2.
Title: Loss of MIG-6 results in endometrial progesterone resistance via ERBB2.
Mig-6 is essential for glucose homeostasis and thermogenesis in brown adipose tissue.
Title: Mig-6 is essential for glucose homeostasis and thermogenesis in brown adipose tissue.
cPLA2 is a novel target of tumor suppressor gene, Mig-6, in the uterus.
Title: A calcium-dependent phospholipase A2 (cPLA2) expression is regulated by MIG-6 during endometrial tumorigenesis.
Mig6 regulates the production of inflammatory mediators (TNF-alpha, il-1beta) through inhibiting the over activation of EGFR.
Title: Mig6 reduces inflammatory mediators production by regulating the activation of EGFR in LPS-induced endotoxemia.
Study in mouse model where Mig-6 is specifically ablated only in the epithelial cells of the uterus suggests that endometrial epithelial cell proliferation is regulated by progesterone (P4) mediated Mig-6 inhibition of AKT phosphorylation, uncovering new mechanisms of P4 action.
Title: MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT.
Study showed that Mig-6 has an important function of tumor suppressor via inhibition of STAT3 phosphorylation in uterine epithelial cells, and the antitumor effects of progesterone are mediated by the endometrial stroma.
Title: MIG-6 negatively regulates STAT3 phosphorylation in uterine epithelial cells.
Mig-6 deficiency promotes the development of Kras(G12D)-induced lung adenoma through reducing the cell apoptosis in Kras(G12D) mouse lungs partially by activating the ErbB4 pathway.
Title: Mig-6 deficiency cooperates with oncogenic Kras to promote mouse lung tumorigenesis.
Studies indicate that progesterone receptor transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 and its target genes.
Title: Mig-6 Mouse Model of Endometrial Cancer.
mouse Mig-6 ablation in the liver results in multiple metabolic phenotypes such as fatty liver, fasting hyperglycemia, and hypercholesterolemia but in lower bodyweight and improved insulin sensitivity.
Title: Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bile acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fat pad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within limb joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor-activated receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor-activated receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of protein kinase activity by regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within progesterone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of keratinocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to 1-oleoyl-sn-glycerol 3-phosphate	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to estradiol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to progesterone	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to progesterone	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to steroid hormone	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within uterine epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within uterus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ERBB receptor feedback inhibitor 1

Names: mitogen-inducible gene 6 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356323.1 → NP_001343252.1 ERBB receptor feedback inhibitor 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK166791, AL607084, BP754554

Consensus CDS

CCDS18974.1

UniProtKB/Swiss-Prot

Q99JZ7

UniProtKB/TrEMBL

Q3TJN8, Q3TK48

Related

ENSMUSP00000073285.3, ENSMUST00000073600.9

Conserved Domains (2) summary

pfam09027
Location:4 → 48

GTPase_binding; GTPase binding

pfam11555
Location:314 → 366

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
NM_133753.2 → NP_598514.1 ERBB receptor feedback inhibitor 1

See identical proteins and their annotated locations for NP_598514.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK166791, BB870611, BP754554

Consensus CDS

CCDS18974.1

UniProtKB/Swiss-Prot

Q99JZ7

UniProtKB/TrEMBL

Q3TJN8, Q3TK48

Related

ENSMUSP00000030811.2, ENSMUST00000030811.2

Conserved Domains (2) summary

pfam09027
Location:4 → 48

GTPase_binding; GTPase binding

pfam11555
Location:314 → 366

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6