U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hcst hematopoietic cell signal transducer [ Mus musculus (house mouse) ]

    Gene ID: 23900, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hcstprovided by MGI
    Official Full Name
    hematopoietic cell signal transducerprovided by MGI
    Primary source
    MGI:MGI:1344360
    See related
    Ensembl:ENSMUSG00000064109 AllianceGenome:MGI:1344360
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAP10; KAP10
    Summary
    Predicted to enable phosphatidylinositol 3-kinase binding activity; protein-macromolecule adaptor activity; and signaling receptor binding activity. Predicted to be involved in natural killer cell mediated cytotoxicity; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and protein phosphorylation. Predicted to be located in cell surface and membrane. Predicted to be active in plasma membrane. Is expressed in ductus deferens; epididymis; esophagus; prostate gland; and testis. Orthologous to human HCST (hematopoietic cell signal transducer). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 65.0), thymus adult (RPKM 46.5) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hcst in Genome Data Viewer
    Location:
    7 B1; 7 17.45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30117137..30119279, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30417712..30419854, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32029 Neighboring gene TYRO protein tyrosine kinase binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:31204808-31204961 Neighboring gene STARR-positive B cell enhancer ABC_E8837 Neighboring gene STARR-positive B cell enhancer ABC_E4916 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta Neighboring gene predicted gene, 30646

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol 3-kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol 3-kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hematopoietic cell signal transducer
    Names
    DNAX-activation protein 10
    membrane protein DAP10
    transmembrane adapter protein KAP10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011827.3NP_035957.2  hematopoietic cell signal transducer precursor

      See identical proteins and their annotated locations for NP_035957.2

      Status: PROVISIONAL

      Source sequence(s)
      AF172930
      Consensus CDS
      CCDS39882.1
      UniProtKB/Swiss-Prot
      Q9QUJ0, Q9R1E7
      UniProtKB/TrEMBL
      B7ZNZ7
      Related
      ENSMUSP00000074573.4, ENSMUST00000075062.5
      Conserved Domains (1) summary
      pfam07213
      Location:179
      DAP10; DAP10 membrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30117137..30119279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)