Ncam1 neural cell adhesion molecule 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncam1provided by MGI
Official Full Name: neural cell adhesion molecule 1provided by MGI
Primary source: MGI:MGI:97281
See related: Ensembl:ENSMUSG00000039542 AllianceGenome:MGI:97281
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD56; Ncam; E-NCAM; NCAM-1
Summary: Predicted to enable LRR domain binding activity and phosphatase binding activity. Involved in commissural neuron axon guidance; epithelial to mesenchymal transition; and regulation of semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including homotypic cell-cell adhesion; positive regulation of calcium-mediated signaling; and regulation of exocyst assembly. Located in several cellular components, including external side of plasma membrane; growth cone; and neuronal cell body. Is expressed in several structures, including embryo mesenchyme; genitourinary system; nervous system; sensory organ; and skin. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 29.9), whole brain E14.5 (RPKM 28.6) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 26.83 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (49413434..49710909, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (49502129..49799393, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1.
Title: Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1.
Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/beta-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells.
Title: Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/β-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells.
Polysialylated - neural cell adhesion molecule (PSA-NCAM) promotes recovery of vision after the critical period.
Title: Polysialylated - neural cell adhesion molecule (PSA-NCAM) promotes recovery of vision after the critical period.
Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains.
Title: Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains.
Authors demonstrate that neural cell adhesion molecule 1 (NCAM1) is one of the molecules involved and show that it mediates spine reorganization and contributes to the behavioral sensitization.
Title: Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury.
CD56(neg) Natural Killer cells constitute functionally competent cells sharing many features of bona fide CD56(dim) Natural Killer cells in healthy individuals, but with some distinct characteristics.
Title: Proteome analysis of human CD56(neg) NK cells reveals a homogeneous phenotype surprisingly similar to CD56(dim) NK cells.
PrP and ZIP6 inherited the ability to interact with NCAM1 from their common ZIP ancestors but have since diverged to control distinct posttranslational modifications of NCAM1.
Title: A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.
the effect of NCAM on tyrosine phosphorylation of beta1 integrin was independent of the fibroblast growth factor receptor. These results indicated that NCAM regulates directional lamellipodia formation of BMSCs through beta1 integrin signal-mediated cofilin activity.
Title: NCAM affects directional lamellipodia formation of BMSCs via β1 integrin signal-mediated cofilin activity.
inhibiting NCAM1 would be cardioprotective, counteract the pathological action of TGFbeta1 and reduce heart failure severity.
Title: TGF-β1 affects cell-cell adhesion in the heart in an NCAM1-dependent mechanism.
NCAM deletion in young adult mice reduces recovery after spinal cord injury.
Title: Impact of neural cell adhesion molecule deletion on regeneration after mouse spinal cord injury.

Submit: New GeneRIF Correction See all GeneRIFs (101)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:226059

D9Mit299 (e-PCR), detects polymorphism
- UniSTS:131868

Ncam (e-PCR), detects polymorphism
- UniSTS:158748

Ncam1 (e-PCR), detects polymorphism
- UniSTS:238142

D9Mit46 (e-PCR), detects polymorphism
- UniSTS:131935

Ncam (e-PCR), detects polymorphism
- UniSTS:226144

X15050 (e-PCR)
- UniSTS:125801

Ncam (e-PCR), detects polymorphism
- UniSTS:143991

Ncam (e-PCR), detects polymorphism
- UniSTS:143992

D9Mit94 (e-PCR), detects polymorphism
- UniSTS:131981

RH142318 (e-PCR)
- UniSTS:231565

D9Mit171 (e-PCR), detects polymorphism
- UniSTS:131727

D9Mit98 (e-PCR), detects polymorphism
- UniSTS:131985

D9Mit22 (e-PCR), detects polymorphism
- UniSTS:131779

D9Mit229 (e-PCR), detects polymorphism
- UniSTS:131791

Ncam1 (e-PCR), detects polymorphism
- UniSTS:532433

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables LRR domain binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonal fasciculation	ISO Inferred from Sequence Orthology more info
acts_upstream_of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in commissural neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within homotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal response to stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of exocyst assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of semaphorin-plexin signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in response to lead ion	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in thalamus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	HDA more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neural cell adhesion molecule 1

Names: N-CAM-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081445.2 → NP_001074914.1 neural cell adhesion molecule 1 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 3. The encoded isoform (1), also known as NCAM-140, is shorter than isoform 3.

Source sequence(s)

AC117630, CT025676

Consensus CDS

CCDS40617.1

UniProtKB/TrEMBL

A0A0A6YY47

Related

ENSMUSP00000142275.2, ENSMUST00000193547.6

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 403

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00410
Location:124 → 190

IG_like; Immunoglobulin like

cd00063
Location:499 → 596

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:603 → 684

fn3; Fibronectin type III domain

pfam13927
Location:407 → 484

Ig_3; Immunoglobulin domain
NM_001113204.2 → NP_001106675.1 neural cell adhesion molecule 1 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3), also known as NCAM-180.

Source sequence(s)

AC117630, CT025676

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Conserved Domains (9) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 403

Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00408
Location:419 → 487

IGc2; Immunoglobulin C-2 Type

smart00410
Location:412 → 490

IG_like; Immunoglobulin like

cd00063
Location:499 → 596

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:218 → 305

I-set; Immunoglobulin I-set domain

pfam00041
Location:603 → 684

fn3; Fibronectin type III domain

pfam06121
Location:908 → 1100

DUF959; Domain of Unknown Function (DUF959)
NM_001311065.2 → NP_001297994.1 neural cell adhesion molecule 1 isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. It encodes isoform 4, which is shorter than isoform 3.

Source sequence(s)

AC117630, CT025676

Consensus CDS

CCDS80993.1

UniProtKB/TrEMBL

E9QB01

Related

ENSMUSP00000130668.4, ENSMUST00000166811.9

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 403

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00410
Location:124 → 190

IG_like; Immunoglobulin like

cd00063
Location:499 → 596

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:603 → 685

fn3; Fibronectin type III domain

pfam13927
Location:407 → 484

Ig_3; Immunoglobulin domain
NM_001404722.1 → NP_001391651.1 neural cell adhesion molecule 1 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC117630, CT025676

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7
NM_010875.4 → NP_035005.2 neural cell adhesion molecule 1 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site and polyadenylation site, compared to variant 3. The encoded isoform (2), also known as NCAM-120, has a shorter and distinct C-terminus compared to isoform 3.

Source sequence(s)

AC117630, CT025676

Consensus CDS

CCDS40618.1

UniProtKB/TrEMBL

A0A0A6YWU2, E9Q589

Related

ENSMUSP00000110120.3, ENSMUST00000114476.8

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 403

Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00408
Location:419 → 487

IGc2; Immunoglobulin C-2 Type

smart00410
Location:412 → 490

IG_like; Immunoglobulin like

cd00063
Location:499 → 596

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:218 → 305

I-set; Immunoglobulin I-set domain

pfam00041
Location:603 → 684

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

49413434..49710909 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510071.3 → XP_006510134.1 neural cell adhesion molecule 1 isoform X17

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:613 → 694

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510067.3 → XP_006510130.1 neural cell adhesion molecule 1 isoform X11

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00410
Location:124 → 190

IG_like; Immunoglobulin like

PHA03247
Location:868 → 1103

PHA03247; large tegument protein UL36; Provisional

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:613 → 694

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_017313195.3 → XP_017168684.1 neural cell adhesion molecule 1 isoform X16

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00410
Location:124 → 190

IG_like; Immunoglobulin like

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:613 → 695

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510066.3 → XP_006510129.1 neural cell adhesion molecule 1 isoform X10

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00410
Location:124 → 190

IG_like; Immunoglobulin like

PHA03247
Location:869 → 1104

PHA03247; large tegument protein UL36; Provisional

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:613 → 695

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510070.3 → XP_006510133.1 neural cell adhesion molecule 1 isoform X15

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:614 → 695

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510065.3 → XP_006510128.1 neural cell adhesion molecule 1 isoform X9

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

PHA03247
Location:869 → 1104

PHA03247; large tegument protein UL36; Provisional

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:614 → 695

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510064.3 → XP_006510127.1 neural cell adhesion molecule 1 isoform X8

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

PHA03247
Location:870 → 1105

PHA03247; large tegument protein UL36; Provisional

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:614 → 696

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510063.3 → XP_006510126.1 neural cell adhesion molecule 1 isoform X7

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Related

ENSMUSP00000142331.2, ENSMUST00000194252.6

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

PHA03247
Location:874 → 1109

PHA03247; large tegument protein UL36; Provisional

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:618 → 700

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_036154673.1 → XP_036010566.1 neural cell adhesion molecule 1 isoform X5

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Conserved Domains (8) summary

cd05730
Location:211 → 308

IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains

cd05869
Location:307 → 413

IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)

smart00409
Location:124 → 190

IG; Immunoglobulin

PHA03247
Location:891 → 1126

PHA03247; large tegument protein UL36; Provisional

pfam00041
Location:635 → 717

fn3; Fibronectin type III domain

pfam13927
Location:422 → 494

Ig_3; Immunoglobulin domain

cd00096
Location:433 → 437

Ig; Ig strand B [structural motif]

cd05865
Location:20 → 116

IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
XM_006510057.3 → XP_006510120.1 neural cell adhesion molecule 1 isoform X3

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

PHA03247
Location:904 → 1139

PHA03247; large tegument protein UL36; Provisional

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:648 → 730

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510069.3 → XP_006510132.1 neural cell adhesion molecule 1 isoform X14

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00410
Location:124 → 190

IG_like; Immunoglobulin like

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:649 → 730

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510056.3 → XP_006510119.1 neural cell adhesion molecule 1 isoform X2

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

PHA03247
Location:904 → 1139

PHA03247; large tegument protein UL36; Provisional

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:649 → 730

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510068.3 → XP_006510131.1 neural cell adhesion molecule 1 isoform X13

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00410
Location:124 → 190

IG_like; Immunoglobulin like

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:649 → 731

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510055.3 → XP_006510118.1 neural cell adhesion molecule 1 isoform X1

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

PHA03247
Location:905 → 1140

PHA03247; large tegument protein UL36; Provisional

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:649 → 731

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510062.3 → XP_006510125.1 neural cell adhesion molecule 1 isoform X6

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

PHA03247
Location:875 → 1110

PHA03247; large tegument protein UL36; Provisional

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:619 → 701

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_011242413.3 → XP_011240715.1 neural cell adhesion molecule 1 isoform X18

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 403

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:499 → 596

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:604 → 685

fn3; Fibronectin type III domain

pfam13927
Location:407 → 484

Ig_3; Immunoglobulin domain
XM_006510059.3 → XP_006510122.1 neural cell adhesion molecule 1 isoform X4

UniProtKB/Swiss-Prot

P13594, P13595, Q61949, Q61950, Q6LBU8, Q8BQ96, Q8C4B2, Q921P2, Q9R2A7

Conserved Domains (8) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 403

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

PHA03247
Location:895 → 1130

PHA03247; large tegument protein UL36; Provisional

cd00063
Location:499 → 596

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:639 → 721

fn3; Fibronectin type III domain

pfam13927
Location:407 → 484

Ig_3; Immunoglobulin domain
XM_017313198.3 → XP_017168687.1 neural cell adhesion molecule 1 isoform X22

UniProtKB/TrEMBL

A0A0A6YWU2

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:613 → 694

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510075.4 → XP_006510138.1 neural cell adhesion molecule 1 isoform X21

UniProtKB/TrEMBL

A0A0A6YWU2

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:613 → 695

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510074.4 → XP_006510137.1 neural cell adhesion molecule 1 isoform X20

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00410
Location:124 → 190

IG_like; Immunoglobulin like

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:649 → 730

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_006510073.4 → XP_006510136.1 neural cell adhesion molecule 1 isoform X19

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 413

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:509 → 606

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:649 → 731

fn3; Fibronectin type III domain

pfam13927
Location:417 → 494

Ig_3; Immunoglobulin domain
XM_011242415.3 → XP_011240717.1 neural cell adhesion molecule 1 isoform X24

UniProtKB/TrEMBL

A0A0A6YWU2

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 403

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:499 → 596

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:603 → 685

fn3; Fibronectin type III domain

pfam13927
Location:407 → 484

Ig_3; Immunoglobulin domain
XM_011242414.3 → XP_011240716.1 neural cell adhesion molecule 1 isoform X23

UniProtKB/TrEMBL

A0A0A6YWU2

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 403

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:499 → 596

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:604 → 685

fn3; Fibronectin type III domain

pfam13927
Location:407 → 484

Ig_3; Immunoglobulin domain
XM_011242416.3 → XP_011240718.1 neural cell adhesion molecule 1 isoform X25

Conserved Domains (7) summary

cd05730
Location:211 → 308

Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

cd05865
Location:20 → 115

Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1

cd05869
Location:307 → 403

Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)

smart00409
Location:124 → 190

IG; Immunoglobulin

cd00063
Location:499 → 596

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:639 → 720

fn3; Fibronectin type III domain

pfam13927
Location:407 → 484

Ig_3; Immunoglobulin domain