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    PTPN21 protein tyrosine phosphatase non-receptor type 21 [ Homo sapiens (human) ]

    Gene ID: 11099, updated on 3-Dec-2024

    Summary

    Official Symbol
    PTPN21provided by HGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 21provided by HGNC
    Primary source
    HGNC:HGNC:9651
    See related
    Ensembl:ENSG00000070778 MIM:603271; AllianceGenome:HGNC:9651
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTPD1; PTPRL10
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thyroid (RPKM 8.6), lung (RPKM 8.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PTPN21 in Genome Data Viewer
    Location:
    14q31.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (88465778..88555007, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (82686590..82775829, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (88932122..89021351, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8835 Neighboring gene KCNK10 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5989 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38654 Neighboring gene Sharpr-MPRA regulatory region 1231 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:88685623-88685838 Neighboring gene potassium two pore domain channel subfamily K member 10 Neighboring gene Sharpr-MPRA regulatory region 1180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:88788959-88789618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:88792556-88793070 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:88830965-88831772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8840 Neighboring gene spermatogenesis associated 7 Neighboring gene NANOG hESC enhancer GRCh37_chr14:88948745-88949275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8841 Neighboring gene uncharacterized LOC105370614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89015655-89016472 Neighboring gene RNA, U4 small nuclear 22, pseudogene Neighboring gene proline-rich protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:89084698-89085319 Neighboring gene zinc finger CCCH-type containing 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8843 Neighboring gene EMAP like 5 Neighboring gene MPRA-validated peak2226 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5994 Neighboring gene RNA, U4 small nuclear 92, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein dephosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 21
    Names
    dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)
    protein-tyrosine phosphatase D1
    NP_008970.2
    XP_005267344.1
    XP_011534669.1
    XP_011534670.1
    XP_016876428.1
    XP_054231261.1
    XP_054231262.1
    XP_054231263.1
    XP_054231264.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046949.1 RefSeqGene

      Range
      4773..94002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007039.4NP_008970.2  tyrosine-protein phosphatase non-receptor type 21

      See identical proteins and their annotated locations for NP_008970.2

      Status: REVIEWED

      Source sequence(s)
      AL049834, AL162171, BM930068, DA860560, X79510
      Consensus CDS
      CCDS9884.1
      UniProtKB/Swiss-Prot
      Q16825
      UniProtKB/TrEMBL
      Q8WX29
      Related
      ENSP00000452414.1, ENST00000556564.6
      Conserved Domains (6) summary
      smart00194
      Location:8961166
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:24222
      B41; Band 4.1 homologues
      cd00047
      Location:9231166
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd13188
      Location:217307
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      pfam00373
      Location:109220
      FERM_M; FERM central domain
      pfam09379
      Location:2790
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      88465778..88555007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267287.4XP_005267344.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

      See identical proteins and their annotated locations for XP_005267344.1

      UniProtKB/Swiss-Prot
      Q16825
      UniProtKB/TrEMBL
      Q8WX29
      Related
      ENSP00000330276.3, ENST00000328736.7
      Conserved Domains (6) summary
      smart00194
      Location:8961166
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:24222
      B41; Band 4.1 homologues
      cd00047
      Location:9231166
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd13188
      Location:217307
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      pfam00373
      Location:109220
      FERM_M; FERM central domain
      pfam09379
      Location:2790
      FERM_N; FERM N-terminal domain
    2. XM_011536367.4XP_011534669.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

      See identical proteins and their annotated locations for XP_011534669.1

      UniProtKB/Swiss-Prot
      Q16825
      UniProtKB/TrEMBL
      Q8WX29
      Conserved Domains (6) summary
      smart00194
      Location:8961166
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:24222
      B41; Band 4.1 homologues
      cd00047
      Location:9231166
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd13188
      Location:217307
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      pfam00373
      Location:109220
      FERM_M; FERM central domain
      pfam09379
      Location:2790
      FERM_N; FERM N-terminal domain
    3. XM_011536368.3XP_011534670.1  tyrosine-protein phosphatase non-receptor type 21 isoform X2

      See identical proteins and their annotated locations for XP_011534670.1

      UniProtKB/TrEMBL
      Q8WX29
      Conserved Domains (4) summary
      smart00194
      Location:7731043
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:8001043
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd13188
      Location:94184
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      pfam00373
      Location:2797
      FERM_M; FERM central domain
    4. XM_017020939.2XP_016876428.1  tyrosine-protein phosphatase non-receptor type 21 isoform X3

      UniProtKB/TrEMBL
      Q8WX29
      Conserved Domains (3) summary
      smart00194
      Location:692962
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:719962
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd13188
      Location:13103
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      82686590..82775829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375286.1XP_054231261.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

      UniProtKB/Swiss-Prot
      Q16825
      UniProtKB/TrEMBL
      Q8WX29
    2. XM_054375287.1XP_054231262.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

      UniProtKB/Swiss-Prot
      Q16825
      UniProtKB/TrEMBL
      Q8WX29
    3. XM_054375288.1XP_054231263.1  tyrosine-protein phosphatase non-receptor type 21 isoform X2

      UniProtKB/TrEMBL
      Q8WX29
    4. XM_054375289.1XP_054231264.1  tyrosine-protein phosphatase non-receptor type 21 isoform X3

      UniProtKB/TrEMBL
      Q8WX29