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    Ankrd45 ankyrin repeat domain 45 [ Mus musculus (house mouse) ]

    Gene ID: 73844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankrd45provided by MGI
    Official Full Name
    ankyrin repeat domain 45provided by MGI
    Primary source
    MGI:MGI:1921094
    See related
    Ensembl:ENSMUSG00000044835 AllianceGenome:MGI:1921094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933409K03Rik
    Summary
    Predicted to be involved in cell population proliferation. Predicted to be located in cleavage furrow; cytoplasm; and midbody. Orthologous to human ANKRD45 (ankyrin repeat domain 45). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 11.2), CNS E18 (RPKM 7.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd45 in Genome Data Viewer
    Location:
    1 H2.1; 1 69.75 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160970017..160998077)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161142447..161170510)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163000837-163001115 Neighboring gene STARR-positive B cell enhancer ABC_E11097 Neighboring gene centromere protein L Neighboring gene kelch-like 20 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163061431-163061751 Neighboring gene STARR-seq mESC enhancer starr_02813 Neighboring gene STARR-seq mESC enhancer starr_02814 Neighboring gene STARR-seq mESC enhancer starr_02815 Neighboring gene STARR-seq mESC enhancer starr_02817 Neighboring gene testis expressed 50 Neighboring gene predicted gene, 51252 Neighboring gene solute carrier family 9, member C2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cleavage furrow ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368766.1 → NP_001355695.1  ankyrin repeat domain-containing protein 45 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138640
      Consensus CDS
      CCDS87902.1
      UniProtKB/Swiss-Prot
      Q810N6
      UniProtKB/TrEMBL
      D3YVW9
      Conserved Domains (3) summary
      PTZ00009
      Location:185 → 239
      PTZ00009; heat shock 70 kDa protein; Provisional
      sd00045
      Location:76 → 106
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 139
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_028664.1 → NP_082940.1  ankyrin repeat domain-containing protein 45 isoform 1

      See identical proteins and their annotated locations for NP_082940.1

      Status: VALIDATED

      Source sequence(s)
      AC138640, BC049713, BY125708
      Consensus CDS
      CCDS48414.1
      UniProtKB/TrEMBL
      G3X9E0
      Related
      ENSMUSP00000059923.9, ENSMUST00000052245.9
      Conserved Domains (3) summary
      cd00204
      Location:96 → 195
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:110 → 163
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:110 → 140
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      160970017..160998077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243188.2 → XP_030099048.1  ankyrin repeat domain-containing protein 45 isoform X3

      UniProtKB/TrEMBL
      D3YVW9
      Related
      ENSMUSP00000117977.2, ENSMUST00000125018.8
      Conserved Domains (3) summary
      PTZ00009
      Location:185 → 239
      PTZ00009; heat shock 70 kDa protein; Provisional
      sd00045
      Location:76 → 106
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 139
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_030243192.2 → XP_030099052.1  ankyrin repeat domain-containing protein 45 isoform X4

      UniProtKB/Swiss-Prot
      Q810N6
      UniProtKB/TrEMBL
      D3YVW9
      Related
      ENSMUSP00000107235.2, ENSMUST00000111608.8
      Conserved Domains (3) summary
      PTZ00009
      Location:185 → 239
      PTZ00009; heat shock 70 kDa protein; Provisional
      sd00045
      Location:76 → 106
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 139
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_030243184.2 → XP_030099044.2  ankyrin repeat domain-containing protein 45 isoform X1

      Conserved Domains (3) summary
      PTZ00009
      Location:246 → 300
      PTZ00009; heat shock 70 kDa protein; Provisional
      sd00045
      Location:137 → 167
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:123 → 200
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_006496995.5 → XP_006497058.3  ankyrin repeat domain-containing protein 45 isoform X2

      Conserved Domains (3) summary
      PTZ00009
      Location:197 → 251
      PTZ00009; heat shock 70 kDa protein; Provisional
      sd00045
      Location:88 → 118
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:74 → 151
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_030243189.2 → XP_030099049.1  ankyrin repeat domain-containing protein 45 isoform X3

      UniProtKB/TrEMBL
      D3YVW9
      Conserved Domains (3) summary
      PTZ00009
      Location:185 → 239
      PTZ00009; heat shock 70 kDa protein; Provisional
      sd00045
      Location:76 → 106
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 139
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_030243190.2 → XP_030099050.1  ankyrin repeat domain-containing protein 45 isoform X3

      UniProtKB/TrEMBL
      D3YVW9
      Conserved Domains (3) summary
      PTZ00009
      Location:185 → 239
      PTZ00009; heat shock 70 kDa protein; Provisional
      sd00045
      Location:76 → 106
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 139
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_017312486.3 → XP_017167975.1  ankyrin repeat domain-containing protein 45 isoform X4

      UniProtKB/Swiss-Prot
      Q810N6
      UniProtKB/TrEMBL
      D3YVW9
      Conserved Domains (3) summary
      PTZ00009
      Location:185 → 239
      PTZ00009; heat shock 70 kDa protein; Provisional
      sd00045
      Location:76 → 106
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 139
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_030243191.2 → XP_030099051.1  ankyrin repeat domain-containing protein 45 isoform X3

      UniProtKB/TrEMBL
      D3YVW9
      Conserved Domains (3) summary
      PTZ00009
      Location:185 → 239
      PTZ00009; heat shock 70 kDa protein; Provisional
      sd00045
      Location:76 → 106
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 139
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_017312485.3 → XP_017167974.1  ankyrin repeat domain-containing protein 45 isoform X3

      UniProtKB/TrEMBL
      D3YVW9
      Conserved Domains (3) summary
      PTZ00009
      Location:185 → 239
      PTZ00009; heat shock 70 kDa protein; Provisional
      sd00045
      Location:76 → 106
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 139
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810N6.1 GenPept UniProtKB/Swiss-Prot:Q810N6

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