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    Timm17b translocase of inner mitochondrial membrane 17b [ Mus musculus (house mouse) ]

    Gene ID: 21855, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Timm17bprovided by MGI
    Official Full Name
    translocase of inner mitochondrial membrane 17bprovided by MGI
    Primary source
    MGI:MGI:1343176
    See related
    Ensembl:ENSMUSG00000031158 AllianceGenome:MGI:1343176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfc3; 17kDa; mTim17b
    Summary
    Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial inner membrane. Orthologous to human TIMM17B (translocase of inner mitochondrial membrane 17B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 27.9), ovary adult (RPKM 20.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Timm17b in Genome Data Viewer
    Location:
    X A1.1; X 3.56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7765575..7773891)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7899336..7907652)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 (UDP-galactose transporter), member A2 Neighboring gene STARR-positive B cell enhancer ABC_E7684 Neighboring gene polyglutamine binding protein 1 Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene STARR-seq mESC enhancer starr_46677 Neighboring gene ES cell-expressed Ras Neighboring gene histone deacetylase 6 Neighboring gene STARR-seq mESC enhancer starr_46678 Neighboring gene STARR-seq mESC enhancer starr_46679

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. Bauer MF, et al. J Mol Biol, 1999 May 28. PMID 10339406
    2. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, et al. Genomics, 2000 May 1. PMID 10857745
    3. The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Bebee TW, et al. Elife, 2015 Sep 15. PMID 26371508, Free PMC Article
    4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim17-B
    Names
    translocator of inner mitochondrial membrane 17 kDa, b
    translocator of inner mitochondrial membrane 17b
    translocator of inner mitochondrial membrane b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313693.1 → NP_001300622.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK049584, AL670169, W46058
      UniProtKB/TrEMBL
      Q3UBR8
      Conserved Domains (1) summary
      cl02381
      Location:1 → 149
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    2. NM_011591.5 → NP_035721.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 1

      See identical proteins and their annotated locations for NP_035721.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK049584, AL670169, AL671978
      Consensus CDS
      CCDS29978.1
      UniProtKB/Swiss-Prot
      Q9Z0V7
      UniProtKB/TrEMBL
      Q3UBR8, Q545H3
      Related
      ENSMUSP00000033498.4, ENSMUST00000033498.11
      Conserved Domains (1) summary
      cl02381
      Location:1 → 171
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    RNA

    1. NR_132589.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK049584, AL670169, AL671978, BY294049

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7765575..7773891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0V7.1 GenPept UniProtKB/Swiss-Prot:Q9Z0V7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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