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    VXN vexin [ Homo sapiens (human) ]

    Gene ID: 254778, updated on 9-Dec-2024

    Summary

    Official Symbol
    VXNprovided by HGNC
    Official Full Name
    vexinprovided by HGNC
    Primary source
    HGNC:HGNC:28498
    See related
    Ensembl:ENSG00000169085 AllianceGenome:HGNC:28498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C8orf46
    Summary
    Predicted to be involved in neuron differentiation. Predicted to be located in nucleus and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 41.0) and prostate (RPKM 1.1) See more
    Orthologs
    NEW
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    Genomic context

    See VXN in Genome Data Viewer
    Location:
    8q13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (66493566..66518524)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (66919332..66944291)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67405801..67430759)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19253 Neighboring gene NANOG hESC enhancer GRCh37_chr8:67358104-67358753 Neighboring gene alcohol dehydrogenase iron containing 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:67370279-67370807 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27481 Neighboring gene uncharacterized LOC124901955 Neighboring gene RNA, U6 small nuclear 1324, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:67453792-67454308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27482 Neighboring gene MYB proto-oncogene like 1 Neighboring gene MPRA-validated peak7058 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:67504290-67504448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19254 Neighboring gene uncharacterized LOC105375884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27485

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: ADHFE1

    Clone Names

    • MGC33510

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    vexin
    Names
    uncharacterized protein C8orf46

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152765.4NP_689978.2  vexin

      See identical proteins and their annotated locations for NP_689978.2

      Status: VALIDATED

      Source sequence(s)
      AK055047, BC028400, H17010
      Consensus CDS
      CCDS6191.2
      UniProtKB/Swiss-Prot
      B2RDC3, B4DFU4, C9J814, C9JCS3, Q8TAG6
      Related
      ENSP00000302260.3, ENST00000305454.8
      Conserved Domains (1) summary
      pfam15505
      Location:43207
      DUF4648; Domain of unknown function (DUF4648)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      66493566..66518524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      66919332..66944291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)