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    Znhit6 zinc finger, HIT type 6 [ Mus musculus (house mouse) ]

    Gene ID: 229937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Znhit6provided by MGI
    Official Full Name
    zinc finger, HIT type 6provided by MGI
    Primary source
    MGI:MGI:1916996
    See related
    Ensembl:ENSMUSG00000074182 AllianceGenome:MGI:1916996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410019A14Rik
    Summary
    Predicted to enable ATPase binding activity; TFIID-class transcription factor complex binding activity; and identical protein binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); protein-containing complex assembly; and snoRNA localization. Predicted to be part of pre-snoRNP complex. Predicted to be active in nucleus. Orthologous to human ZNHIT6 (zinc finger HIT-type containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 7.2), CNS E14 (RPKM 4.5) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Znhit6 in Genome Data Viewer
    Location:
    3 H2; 3 69.89 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145281943..145313570)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145576201..145605245)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1637 Neighboring gene STARR-positive B cell enhancer mm9_chr3:144794197-144794498 Neighboring gene outer dense fiber of sperm tails 2-like Neighboring gene collagen, type XXIV, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_09192 Neighboring gene predicted gene, 35133 Neighboring gene STARR-seq mESC enhancer starr_09193 Neighboring gene STARR-seq mESC enhancer starr_09194 Neighboring gene STARR-seq mESC enhancer starr_09195 Neighboring gene STARR-seq mESC enhancer starr_09196 Neighboring gene STARR-seq mESC enhancer starr_09197 Neighboring gene STARR-seq mESC enhancer starr_09198 Neighboring gene predicted gene, 40164 Neighboring gene cellular communication network factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TFIID-class transcription factor complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TFIID-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in box C/D snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in box C/D snoRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in box C/D snoRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein complex oligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snoRNA localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snoRNA localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snoRNA localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pre-snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pre-snoRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pre-snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    box C/D snoRNA protein 1
    Names
    zinc finger HIT domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081094.1 → NP_001074563.1  box C/D snoRNA protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001074563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC136729
      Consensus CDS
      CCDS38662.1
      UniProtKB/Swiss-Prot
      B2RW16, Q3TG81, Q3UFB2
      Related
      ENSMUSP00000096136.5, ENSMUST00000098534.9
      Conserved Domains (1) summary
      pfam04438
      Location:210 → 237
      zf-HIT; HIT zinc finger

    2. NM_001346521.1 → NP_001333450.1  box C/D snoRNA protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AA509476, AK168844, BQ031699, BY141293
      Consensus CDS
      CCDS84683.1
      UniProtKB/Swiss-Prot
      Q3UFB2
      Related
      ENSMUSP00000143306.2, ENSMUST00000199033.5
      Conserved Domains (1) summary
      pfam04438
      Location:42 → 69
      zf-HIT; HIT zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      145281943..145313570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501437.5 → XP_006501500.1  box C/D snoRNA protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006501500.1

      Conserved Domains (1) summary
      pfam04438
      Location:66 → 93
      zf-HIT; HIT zinc finger

    2. XM_006501436.5 → XP_006501499.1  box C/D snoRNA protein 1 isoform X1

      Conserved Domains (1) summary
      pfam04438
      Location:210 → 237
      zf-HIT; HIT zinc finger

    3. XM_006501439.3 → XP_006501502.1  box C/D snoRNA protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006501502.1

      UniProtKB/Swiss-Prot
      Q3UFB2
      Conserved Domains (1) summary
      pfam04438
      Location:42 → 69
      zf-HIT; HIT zinc finger

    RNA

    1. XR_004941318.1 RNA Sequence

    2. XR_375523.4 RNA Sequence

    3. XR_004941319.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UFB2.2 GenPept UniProtKB/Swiss-Prot:Q3UFB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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