U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Hs3st2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 195646, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hs3st2provided by MGI
    Official Full Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 2provided by MGI
    Primary source
    MGI:MGI:1333802
    See related
    Ensembl:ENSMUSG00000046321 AllianceGenome:MGI:1333802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6430516N12Rik; A830061E14Rik
    Summary
    Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and skeleton. Human ortholog(s) of this gene implicated in colon cancer; lung cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 2.9), cortex adult (RPKM 2.5) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hs3st2 in Genome Data Viewer
    Location:
    7 F2; 7 65.07 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120990785..121196555)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (121391585..121501768)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene src family associated phosphoprotein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20061 Neighboring gene predicted gene, 36736 Neighboring gene STARR-seq mESC enhancer starr_20062 Neighboring gene STARR-seq mESC enhancer starr_20063 Neighboring gene STARR-positive B cell enhancer mm9_chr7:128623661-128623961 Neighboring gene predicted gene, 39081 Neighboring gene RIKEN cDNA 4933432K03 gene Neighboring gene RIKEN cDNA 1700025J12 gene Neighboring gene STARR-positive B cell enhancer ABC_E10470 Neighboring gene ubiquitin specific peptidase 31 Neighboring gene STARR-positive B cell enhancer ABC_E6594 Neighboring gene STARR-positive B cell enhancer ABC_E8205 Neighboring gene STARR-seq mESC enhancer starr_20066 Neighboring gene sodium channel, nonvoltage-gated 1 gamma Neighboring gene predicted gene, 36848

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in Golgi membrane  
    is_active_in cellular_component  

    General protein information

    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 2
    Names
    heparan sulfate 3-O-sulfotransferase 2
    heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2
    NP_001074796.1
    NP_001406126.1
    XP_006507527.1
    XP_006507529.1
    XP_030098100.1
    XP_030098101.1
    XP_036008693.1
    XP_036008694.1
    XP_036008695.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081327.2NP_001074796.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_001074796.1

      Status: VALIDATED

      Source sequence(s)
      AC098715, AC125331
      Consensus CDS
      CCDS40115.1
      UniProtKB/Swiss-Prot
      Q673U1, Q8BLP1, Q8C055
      Related
      ENSMUSP00000081678.4, ENSMUST00000084628.5
      Conserved Domains (1) summary
      pfam00685
      Location:114351
      Sulfotransfer_1; Sulfotransferase domain
    2. NM_001419197.1NP_001406126.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC098715, AC125331

    RNA

    1. NR_185034.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC098715, AC125331

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      120990785..121196555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152801.1XP_036008694.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X6

      Conserved Domains (1) summary
      pfam00685
      Location:2187
      Sulfotransfer_1; Sulfotransferase domain
    2. XM_030242240.2XP_030098100.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X6

      Conserved Domains (1) summary
      pfam00685
      Location:2187
      Sulfotransfer_1; Sulfotransferase domain
    3. XM_036152802.1XP_036008695.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X7

      Conserved Domains (1) summary
      cl21551
      Location:131181
      Sulfotransfer_3; Sulfotransferase family
    4. XM_006507464.1XP_006507527.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X1

      Conserved Domains (1) summary
      pfam00685
      Location:131368
      Sulfotransfer_1; Sulfotransferase domain
    5. XM_030242241.1XP_030098101.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X8

      Conserved Domains (1) summary
      cl21551
      Location:131184
      Sulfotransfer_3; Sulfotransferase family
    6. XM_006507466.4XP_006507529.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X4

      Conserved Domains (1) summary
      cl21551
      Location:131178
      Sulfotransfer_3; Sulfotransferase family
    7. XM_036152800.1XP_036008693.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X3

      Conserved Domains (1) summary
      cl21551
      Location:131182
      Sulfotransfer_3; Sulfotransferase family

    RNA

    1. XR_004934044.1 RNA Sequence

    External link. Please review our privacy policy.