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    NABP1 nucleic acid binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 64859, updated on 9-Dec-2024

    Summary

    Official Symbol
    NABP1provided by HGNC
    Official Full Name
    nucleic acid binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:26232
    See related
    Ensembl:ENSG00000173559 MIM:612103; AllianceGenome:HGNC:26232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SSB2; OBFC2A; SOSS-B2; NABP1-OT1
    Summary
    Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
    Expression
    Broad expression in appendix (RPKM 17.5), spleen (RPKM 12.9) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NABP1 in Genome Data Viewer
    Location:
    2q32.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (191678136..191686943)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (192167017..192175824)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (192542862..192551669)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985833 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:192406286-192406448 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:192428730-192429929 Neighboring gene Sharpr-MPRA regulatory region 3391 Neighboring gene CRISPRi-validated cis-regulatory element chr2.5925 Neighboring gene uncharacterized LOC124905959 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:192510916-192511055 Neighboring gene Sharpr-MPRA regulatory region 14503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16883 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:192542703-192543205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12197 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:192544033-192545232 Neighboring gene uncharacterized LOC124900605 Neighboring gene uncharacterized LOC124908062

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ13624, FLJ22833, FLJ26671, MGC111163, DKFZp667M1322

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of SOSS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SOSS complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SOSS complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    SOSS complex subunit B2
    Names
    NABP1 3'UTR overlapping transcript 1
    lncRNA AK130181
    oligonucleotide/oligosaccharide-binding fold containing 2A
    oligonucleotide/oligosaccharide-binding fold-containing protein 2A
    sensor of single-strand DNA complex subunit B2
    sensor of ssDNA subunit B2
    single-stranded DNA-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031716.5NP_001026886.1  SOSS complex subunit B2 isoform 1

      See identical proteins and their annotated locations for NP_001026886.1

      Status: VALIDATED

      Source sequence(s)
      AC114778
      Consensus CDS
      CCDS33352.1
      UniProtKB/Swiss-Prot
      Q658Y8, Q96AH0, Q9H5X6
      UniProtKB/TrEMBL
      H7C0W4
      Related
      ENSP00000403683.2, ENST00000425611.9
      Conserved Domains (1) summary
      cd04491
      Location:2299
      SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
    2. NM_001254736.3NP_001241665.1  SOSS complex subunit B2 isoform 2

      See identical proteins and their annotated locations for NP_001241665.1

      Status: VALIDATED

      Source sequence(s)
      AC114778
      Consensus CDS
      CCDS58745.1
      UniProtKB/Swiss-Prot
      Q96AH0
      Related
      ENSP00000387243.1, ENST00000410026.7

    RNA

    1. NR_045622.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114778
      Related
      ENST00000307834.9
    2. NR_045623.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114778

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      191678136..191686943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445531.1XP_047301487.1  SOSS complex subunit B2 isoform X1

    2. XM_047445532.1XP_047301488.1  SOSS complex subunit B2 isoform X1

      Related
      ENSP00000390901.1, ENST00000451500.5

    RNA

    1. XR_007080680.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      192167017..192175824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343422.1XP_054199397.1  SOSS complex subunit B2 isoform X1

    2. XM_054343423.1XP_054199398.1  SOSS complex subunit B2 isoform X1

    RNA

    1. XR_008486492.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_131917.1: Suppressed sequence

      Description
      NR_131917.1: This RefSeq was removed because currently there is insufficient support for the transcript.