Kera keratocan [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Keraprovided by MGI
Official Full Name: keratocanprovided by MGI
Primary source: MGI:MGI:1202398
See related: Ensembl:ENSMUSG00000019932 AllianceGenome:MGI:1202398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KTN; CNA2; SLRR2B
Summary: Acts upstream of or within cornea development in camera-type eye. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; connective tissue; jaw; limb; and sensory organ. Used to study cornea plana. Human ortholog(s) of this gene implicated in arcus senilis; cornea plana; and corneal dystrophy. Orthologous to human KERA (keratocan). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward limb E14.5 (RPKM 43.4) See more
Orthologs: human all
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Genomic context

Location:: 10 C3; 10 50.34 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (97442873..97449555)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (97606962..97613688)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stromal matrix directs corneal fibroblasts to re-express keratocan after injury and transplantation.
Title: Stromal matrix directs corneal fibroblasts to re-express keratocan after injury and transplantation.
rare variant in KERA was identified in a large kindred with premature atherosclerosis
Title: Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis.
our results demonstrate the expression of keratocan by osteoblast lineage cells and its ability to modulate osteoblast function.
Title: Keratocan is expressed by osteoblasts and can modulate osteogenic differentiation.
lumican and keratocan core proteins bind the CXC chemokine KC during a corneal inflammatory response, indicating that corneal KSPGs mediate neutrophil recruitment to the cornea by regulating chemokine gradient formation.
Title: Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1.
Keratocan-deficient mice have corneal collagen fibrils with significantly larger diameters than those in wild-type mice, and increased centre-to-centre spacing of the fibrils.
Title: An X-ray scattering investigation of corneal structure in keratocan-deficient mice.
Keratocan plays a unique role in maintaining the appropriate corneal shape to ensure normal vision
Title: Keratocan-deficient mice display alterations in corneal structure.
lumican has a novel regulatory role in keratocan expression at the transcriptional level
Title: Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cornea development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: keratocan

Names: keratan sulfate proteoglycan keratocan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008438.3 → NP_032464.1 keratocan precursor

See identical proteins and their annotated locations for NP_032464.1

Status: VALIDATED

Source sequence(s)

AC159710

Consensus CDS

CCDS36044.1

UniProtKB/Swiss-Prot

O35367

UniProtKB/TrEMBL

A4FUJ3, Q8C3D9

Related

ENSMUSP00000100923.3, ENSMUST00000105286.4

Conserved Domains (3) summary

PRK15370
Location:16 → 298

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

sd00033
Location:74 → 97

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:268 → 331

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

97442873..97449555

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513273.5 → XP_006513336.1 keratocan isoform X1

See identical proteins and their annotated locations for XP_006513336.1

UniProtKB/Swiss-Prot

O35367

UniProtKB/TrEMBL

A4FUJ3, Q8C3D9

Conserved Domains (3) summary

PRK15370
Location:16 → 298

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

sd00033
Location:74 → 97

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:268 → 331

LRR_8; Leucine rich repeat