Kif5b kinesin family member 5B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif5bprovided by MGI
Official Full Name: kinesin family member 5Bprovided by MGI
Primary source: MGI:MGI:1098268
See related: Ensembl:ENSMUSG00000006740 AllianceGenome:MGI:1098268
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Khc; Khcs; Kns1; Ukhc
Summary: Predicted to enable several functions, including ATP hydrolysis activity; JUN kinase binding activity; and microtubule lateral binding activity. Involved in positive regulation of GABAergic synaptic transmission; regulation of modification of synapse structure, modulating synaptic transmission; and stress granule disassembly. Acts upstream of or within several processes, including cellular response to type II interferon; mitocytosis; and organelle transport along microtubule. Located in several cellular components, including ciliary rootlet; mitochondrion; and phagocytic vesicle. Is active in postsynaptic cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human KIF5B (kinesin family member 5B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 26.1), bladder adult (RPKM 26.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 4.46 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (6201005..6241524, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (6201005..6241524, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF5B plays important roles in dendritic spine plasticity and dendritic localization of PSD95 and FMRP in the mouse cortex in vivo.
Title: KIF5B plays important roles in dendritic spine plasticity and dendritic localization of PSD95 and FMRP in the mouse cortex in vivo.
Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling.
Title: Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling.
these results revealed an important role for Kif5b in the modulation of the striatal network that is relevant to the overall locomotor response
Title: Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors.
Kif5 controls microtubule trafficking and membrane targeting of the mGlu1a receptor.
Title: SNAP23-Kif5 complex controls mGlu1 receptor trafficking.
Kinesin-1-dependent process plays a role for platelet function by acting into the mechanism underlying alpha-granule and dense granule secretion.
Title: Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.
The authors concluded that kinesin-1 proteins KIF5A, -5B, and -5C are important in the anterograde transport of the majority of herpes simplex virus enveloped virions in neuronal axons and kinesin-3 proteins are less important.
Title: Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons.
kinesin and microtubules can compensate for defects in myosin-Va and actin-based transport in mammals, but endogenous Kif5b does not have an important role in transport of melanocytes due to its inefficient recruitment to melanosomes
Title: Inefficient recruitment of kinesin-1 to melanosomes precludes it from facilitating their transport.
High KIF5B expression is associated with Lung Metastasis of Breast Cancer.
Title: Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.
It was concluded that selective deletion of Kif5b in adipose tissue exacerbates HFD-induced obesity and its associated metabolic disorders, partly through a decrease in energy expenditure, dysregulation of adipokine secretion, and insulin signaling.
Title: Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.
PI3K-dependent formation of a kinesin-1/Slp3/Rab27b complex is critical for the microtubule-dependent movement of secretory granules required for mast cell degranulation.
Title: Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124320 (e-PCR)
- UniSTS:161142

RH93349 (e-PCR)
- UniSTS:88977

Kif5b (e-PCR), detects polymorphism
- UniSTS:547252

AI102819 (e-PCR)
- UniSTS:250549

AW742475 (e-PCR)
- UniSTS:209352

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule lateral binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule motor activity	TAS Traceable Author Statement more info	PubMed
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal protein transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in centrosome localization	ISO Inferred from Sequence Orthology more info
involved_in centrosome localization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cytoplasm organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within microtubule-based process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within mitochondrial transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within mitochondrion transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within plus-end-directed vesicle transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of synapse structure, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of synapse structure, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde neuronal dense core vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in stress granule disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vesicle transport along microtubule	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in vesicle transport along microtubule	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in ciliary rootlet	IDA Inferred from Direct Assay more info	PubMed
located_in cytolytic granule membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	TAS Traceable Author Statement more info	PubMed
located_in membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic cytosol	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynaptic cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kinesin-1 heavy chain

Names: conventional kinesin heavy chain; kinesin heavy chain member 5B, ubiquitous; ubiquitous kinesin heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008448.3 → NP_032474.2 kinesin-1 heavy chain

See identical proteins and their annotated locations for NP_032474.2

Status: VALIDATED

Source sequence(s)

AC113003, AI788274, AK014590, AV316286, BC090841

Consensus CDS

CCDS37724.1

UniProtKB/Swiss-Prot

O08711, Q5BL10, Q61580, Q61768

Related

ENSMUSP00000025083.8, ENSMUST00000025083.14

Conserved Domains (5) summary

smart00129
Location:8 → 332

KISc; Kinesin motor, catalytic domain. ATPase

cd01369
Location:6 → 325

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup

pfam05010
Location:467 → 662

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam07851
Location:598 → 686

TMPIT; TMPIT-like protein

pfam14235
Location:462 → 538

DUF4337; Domain of unknown function (DUF4337)