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    Cds2 CDP-diacylglycerol synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 110911, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Cds2provided by MGI
    Official Full Name
    CDP-diacylglycerol synthase 2provided by MGI
    Primary source
    MGI:MGI:1332236
    See related
    Ensembl:ENSMUSG00000058793 AllianceGenome:MGI:1332236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D2Wsu127e; 5730450N06Rik; 5730460C18Rik
    Summary
    Predicted to enable phosphatidate cytidylyltransferase activity. Involved in lipid droplet formation. Located in endoplasmic reticulum. Is expressed in several structures, including central nervous system; immune system; retina; skin; and testis. Orthologous to human CDS2 (CDP-diacylglycerol synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 33.8), frontal lobe adult (RPKM 33.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cds2 in Genome Data Viewer
    Location:
    2 F2; 2 64.15 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132105068..132153970)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132253338..132312050)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:132079079-132079188 Neighboring gene STARR-positive B cell enhancer ABC_E331 Neighboring gene expressed sequence AV099323 Neighboring gene proliferating cell nuclear antigen Neighboring gene predicted gene, 46766 Neighboring gene STARR-seq mESC enhancer starr_05740 Neighboring gene STARR-positive B cell enhancer ABC_E5987 Neighboring gene STARR-seq mESC enhancer starr_05741 Neighboring gene STARR-seq mESC enhancer starr_05742 Neighboring gene prokineticin receptor 2 Neighboring gene RIKEN cDNA 4921508D12 gene Neighboring gene VISTA enhancer mm1391

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis. Xu J, et al. Sci Bull (Beijing), 2022 Feb 15. PMID 36546079
    2. Increased alpha2,6-sialylation of surface proteins on tolerogenic, immature dendritic cells and regulatory T cells. Jenner J, et al. Exp Hematol, 2006 Sep. PMID 16939814
    3. CDS2 expression regulates de novo phosphatidic acid synthesis. Collins DM, et al. Biochem J, 2024 Oct 16. PMID 39312194, Free PMC Article
    4. Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling. Stratman AN, et al. Nat Commun, 2020 Mar 5. PMID 32139674, Free PMC Article
    5. Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2. Inglis-Broadgate SL, et al. Gene, 2005 Aug 15. PMID 16023307

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis.
      Title: Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis.
    2. Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition.
      Title: Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition.
    3. Cds2 showed a ubiquitous pattern of expression and was mapped to chromosome 2G1.
      Title: Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidate cytidylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidate cytidylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidate cytidylyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CDP-diacylglycerol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CDP-diacylglycerol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycosylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in lipid droplet formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phototransduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidate cytidylyltransferase 2
    Names
    CDP-DAG synthase 2
    CDP-DG synthase 2
    CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
    CDP-diglyceride pyrophosphorylase 2
    CDP-diglyceride synthase 2
    CTP:phosphatidate cytidylyltransferase 2
    NP_001277968.1
    NP_001277969.1
    NP_619592.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291039.1 → NP_001277968.1  phosphatidate cytidylyltransferase 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AI854580, AK017677, AK049257, AK147541, BQ572878, CD351907, CD540005
      Consensus CDS
      CCDS71150.1
      UniProtKB/TrEMBL
      A2AMQ5, Q8BX08
      Related
      ENSMUSP00000086886.5, ENSMUST00000089461.11
      Conserved Domains (1) summary
      cl21502
      Location:88 → 407
      CTP_transf_1; Cytidylyltransferase family

    2. NM_001291040.1 → NP_001277969.1  phosphatidate cytidylyltransferase 2 isoform c

      See identical proteins and their annotated locations for NP_001277969.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK050589, BU610248, CJ112406
      Consensus CDS
      CCDS79850.1
      UniProtKB/TrEMBL
      Q6PBC0
      Related
      ENSMUSP00000105786.2, ENSMUST00000110158.8
      Conserved Domains (2) summary
      pfam04718
      Location:44 → 86
      ATP-synt_G; Mitochondrial ATP synthase g subunit
      cl21502
      Location:69 → 129
      CTP_transf_1; Cytidylyltransferase family

    3. NM_138651.7 → NP_619592.1  phosphatidate cytidylyltransferase 2 isoform a

      See identical proteins and their annotated locations for NP_619592.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AI854580, AK017677, AK147541, BQ572878, CD351907, CJ112406
      Consensus CDS
      CCDS16772.1
      UniProtKB/Swiss-Prot
      Q3TMD1, Q6NSU1, Q99L43
      UniProtKB/TrEMBL
      Q8BX08
      Related
      ENSMUSP00000099470.5, ENSMUST00000103181.11
      Conserved Domains (1) summary
      cl21502
      Location:105 → 424
      CTP_transf_1; Cytidylyltransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      132105068..132153970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_866210.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99L43.1 GenPept UniProtKB/Swiss-Prot:Q99L43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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