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    Krt17 keratin 17 [ Mus musculus (house mouse) ]

    Gene ID: 16667, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krt17provided by MGI
    Official Full Name
    keratin 17provided by MGI
    Primary source
    MGI:MGI:96691
    See related
    Ensembl:ENSMUSG00000035557 AllianceGenome:MGI:96691
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K17; Krt1-17
    Summary
    The protein encoded by this gene is a member of the type I keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin required for the normal growth of hair follicles and may act in psoriasis as an immunopathogenic autoantigen. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in thymus adult (RPKM 78.2), mammary gland adult (RPKM 14.4) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Krt17 in Genome Data Viewer
    Location:
    11 D; 11 63.44 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100147041..100151855, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100256215..100261029, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene Neighboring gene keratin 16 Neighboring gene keratin 42 Neighboring gene STARR-seq mESC enhancer starr_30718 Neighboring gene predicted gene 14206

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis. Liao C, et al. J Invest Dermatol, 2016 Mar. PMID 26747697
    2. Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype. McGowan KM, et al. J Invest Dermatol, 2000 Jun. PMID 10844551
    3. Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage. Yue Z, et al. J Invest Dermatol, 2023 Dec. PMID 37414246
    4. Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment. Wang W, et al. PLoS Pathog, 2020 Jan. PMID 31968015, Free PMC Article
    5. Exploiting the keratin 17 gene promoter to visualize live cells in epithelial appendages of mice. Bianchi N, et al. Mol Cell Biol, 2005 Aug. PMID 16055733, Free PMC Article

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Repeated stress to the skin amplifies neutrophil infiltration in a keratin 17- and PKCalpha-dependent manner.
      Title: Repeated stress to the skin amplifies neutrophil infiltration in a keratin 17- and PKCα-dependent manner.
    2. Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage.
      Title: Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage.
    3. Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and Resistance to Immune-Checkpoint Blockade.
      Title: Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and Resistance to Immune-Checkpoint Blockade.
    4. A role for keratin 17 during DNA damage response and tumor initiation.
      Title: A role for keratin 17 during DNA damage response and tumor initiation.
    5. K17 was critical for preventing T cell infiltration in MmuPV1-induced papillomas by inhibiting the CXCL9/CXCL10/CXCR3 axis
      Title: Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment.
    6. Narrow-band ultraviolet B irradiation with doses of MED or higher could eliminate the imiquimod-induced psoriasis-like dermatitis and inhibit K17 expression via the ERK1/2 and STAT3 signaling pathways.
      Title: NB-UVB irradiation downregulates keratin-17 expression in keratinocytes by inhibiting the ERK1/2 and STAT3 signaling pathways.
    7. TGF-beta1-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway.
      Title: TGF-β1-induced CK17 enhances cancer stem cell-like properties rather than EMT in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway.
    8. the data suggest that the loss of Krt17 may foster an overall protective environment for lesion-prone cervical tissue.
      Title: Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo.
    9. High KR17 expression is associated with oral cancer.
      Title: Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth.
    10. p53 operates as a direct Krt17 repressor that invites therapeutic targeting in radiodermatitis .
      Title: p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intermediate filament organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within keratinization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within morphogenesis of an epithelium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cornified envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cytoskeletal 17
    Names
    CK-17
    cytokeratin-17
    keratin complex 1, acidic, gene 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010663.3 → NP_034793.1  keratin, type I cytoskeletal 17

      See identical proteins and their annotated locations for NP_034793.1

      Status: REVIEWED

      Source sequence(s)
      AL590873, BC132454, EH104192, EH105154
      Consensus CDS
      CCDS25415.1
      UniProtKB/Swiss-Prot
      A2A4G6, Q61783, Q9QWL7
      Related
      ENSMUSP00000079699.7, ENSMUST00000080893.7
      Conserved Domains (1) summary
      pfam00038
      Location:84 → 394
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100147041..100151855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245607.1 → XP_030101467.1  keratin, type I cytoskeletal 17 isoform X1

      Conserved Domains (1) summary
      pfam00038
      Location:25 → 312
      Filament; Intermediate filament protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QWL7.3 GenPept UniProtKB/Swiss-Prot:Q9QWL7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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