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    Vps26a VPS26 retromer complex component A [ Mus musculus (house mouse) ]

    Gene ID: 30930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps26aprovided by MGI
    Official Full Name
    VPS26 retromer complex component Aprovided by MGI
    Primary source
    MGI:MGI:1353654
    See related
    Ensembl:ENSMUSG00000020078 AllianceGenome:MGI:1353654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HB58; Vps26
    Summary
    Acts upstream of or within retrograde transport, endosome to Golgi. Located in early endosome. Part of retromer complex. Is expressed in several structures, including egg cylinder; embryo ectoderm; gut; inner cell mass; and ovary. Human ortholog(s) of this gene implicated in diabetic retinopathy and type 2 diabetes mellitus. Orthologous to human VPS26A (VPS26 retromer complex component A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 37.1), placenta adult (RPKM 23.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vps26a in Genome Data Viewer
    Location:
    10 B4; 10 32.41 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62290622..62322584, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62454843..62486805, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene hexokinase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_26882 Neighboring gene predicted gene, 30322 Neighboring gene suppressor of var1, 3-like 1 (S. cerevisiae) Neighboring gene RIKEN cDNA 4930507D05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912425-61912612 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912686-61912869 Neighboring gene STARR-seq mESC enhancer starr_26885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61949721-61949830 Neighboring gene STARR-seq mESC enhancer starr_26886 Neighboring gene STARR-positive B cell enhancer ABC_E6862 Neighboring gene STARR-positive B cell enhancer ABC_E6863 Neighboring gene STARR-positive B cell enhancer ABC_E6864 Neighboring gene serglycin Neighboring gene STARR-positive B cell enhancer ABC_E10614 Neighboring gene STARR-positive B cell enhancer ABC_E2327 Neighboring gene STARR-positive B cell enhancer ABC_E11441 Neighboring gene STARR-seq mESC enhancer starr_26888 Neighboring gene STARR-positive B cell enhancer ABC_E3889 Neighboring gene kinesin family binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion. Lee JJ, et al. Development, 1992 May. PMID 1638986
    2. H beta 58, an insertional mutation affecting early postimplantation development of the mouse embryo. Radice G, et al. Development, 1991 Mar. PMID 1879343
    3. Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling. Simoes S, et al. Cell Rep, 2021 Dec 28. PMID 34965419, Free PMC Article
    4. Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. Fjorback AW, et al. J Neurosci, 2012 Jan 25. PMID 22279231, Free PMC Article
    5. High glucose-mediated VPS26a down-regulation dysregulates neuronal amyloid precursor protein processing and tau phosphorylation. Chae CW, et al. Br J Pharmacol, 2022 Aug. PMID 35297035

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High glucose-mediated VPS26a down-regulation dysregulates neuronal amyloid precursor protein processing and tau phosphorylation.
      Title: High glucose-mediated VPS26a down-regulation dysregulates neuronal amyloid precursor protein processing and tau phosphorylation.
    2. VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection.
      Title: A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer.
    3. These results revealed that the retromer complex could be formed from different Vps26 isoforms in a tissue-specific manner.
      Title: Identification of novel retromer complexes in the mouse testis.
    4. Vps26 is implicated in regulating Vps35p membrane association, therefore Vps26 plays a role in cargo recognition of the cytoplasmic coat retromer complex.
      Title: Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retrograde transport, endosome to Golgi IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of retromer complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retromer complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of retromer, cargo-selective complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of retromer, cargo-selective complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tubular endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tubular endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 26A
    Names
    H beta 58
    h<beta>58 protein
    mVPS26
    vacuolar protein sorting 26 homolog A
    vacuole protein sorting 26
    vesicle protein sorting 26A

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113355.1 → NP_001106826.1  vacuolar protein sorting-associated protein 26A isoform b

      See identical proteins and their annotated locations for NP_001106826.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG and an isoform (b) with a longer, distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK028096, AK147989, AK167592, CO801094
      Consensus CDS
      CCDS48579.1
      UniProtKB/Swiss-Prot
      P40336
      Related
      ENSMUSP00000090130.4, ENSMUST00000092473.5
      Conserved Domains (1) summary
      pfam03643
      Location:40 → 315
      Vps26; Vacuolar protein sorting-associated protein 26

    2. NM_001358543.1 → NP_001345472.1  vacuolar protein sorting-associated protein 26A isoform c

      Status: VALIDATED

      Source sequence(s)
      AK147989, AK167592, BB857335, CJ151367, CO801094
      Conserved Domains (1) summary
      pfam03643
      Location:2 → 172
      Vps26; Vacuolar protein sorting-associated protein 26

    3. NM_133672.3 → NP_598433.1  vacuolar protein sorting-associated protein 26A isoform a

      See identical proteins and their annotated locations for NP_598433.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AK147989, AK167592, BB857335, CO801094
      Consensus CDS
      CCDS35921.1
      UniProtKB/Swiss-Prot
      P40336, Q3TGY3, Q3THM5, Q3TW99, Q3UD54, Q8C1E9
      Related
      ENSMUSP00000101087.4, ENSMUST00000105447.11
      Conserved Domains (1) summary
      pfam03643
      Location:8 → 283
      Vps26; Vacuolar protein sorting-associated protein 26

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62290622..62322584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40336.1 GenPept UniProtKB/Swiss-Prot:P40336

    Gene LinkOut

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