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    Ubl3 ubiquitin-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 24109, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubl3provided by MGI
    Official Full Name
    ubiquitin-like 3provided by MGI
    Primary source
    MGI:MGI:1344373
    See related
    Ensembl:ENSMUSG00000001687 AllianceGenome:MGI:1344373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HCG; MUB; mmMUB
    Summary
    Predicted to be located in plasma membrane. Orthologous to human UBL3 (ubiquitin like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 50.1), cerebellum adult (RPKM 42.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubl3 in Genome Data Viewer
    Location:
    5 G3; 5 88.66 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (148441441..148489689, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (148504631..148552879, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene microtubule associated tumor suppressor candidate 2 Neighboring gene STARR-seq mESC enhancer starr_14896 Neighboring gene fused in sarcoma pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E675 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 Neighboring gene STARR-seq mESC enhancer starr_14901 Neighboring gene STARR-positive B cell enhancer mm9_chr5:149263482-149263782 Neighboring gene STARR-seq mESC enhancer starr_14907 Neighboring gene STARR-seq mESC enhancer starr_14908 Neighboring gene STARR-seq mESC enhancer starr_14912 Neighboring gene predicted gene, 35735 Neighboring gene predicted gene, 35994 Neighboring gene predicted gene, 35929

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. UBL3 modification influences protein sorting to small extracellular vesicles. Ageta H, et al. Nat Commun, 2018 Sep 26. PMID 30258067, Free PMC Article
    2. Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene. Chadwick BP, et al. Gene, 1999 Jun 11. PMID 10375635
    3. MUBs, a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation. Downes BP, et al. J Biol Chem, 2006 Sep 15. PMID 16831869
    4. Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86. Liu H, et al. Nat Commun, 2022 Apr 11. PMID 35411049, Free PMC Article
    5. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.
      Title: Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like protein 3
    Names
    membrane-anchored ubiquitin-fold protein
    protein HCG-1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359199.1 → NP_001346128.1  ubiquitin-like protein 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC157990, AC158302
      Consensus CDS
      CCDS39403.1
      UniProtKB/Swiss-Prot
      A4FTW0, Q3UKM1, Q9Z2M6
      UniProtKB/TrEMBL
      Q3UYL1
      Related
      ENSMUSP00000131049.2, ENSMUST00000164904.2
      Conserved Domains (1) summary
      cd17048
      Location:10 → 91
      Ubl_UBL3; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins

    2. NM_001359200.1 → NP_001346129.1  ubiquitin-like protein 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AC157990, CA574503
      Conserved Domains (1) summary
      cl28922
      Location:1 → 47
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. NM_001359201.1 → NP_001346130.1  ubiquitin-like protein 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AC157990, AC158302
      Conserved Domains (1) summary
      cl28922
      Location:1 → 47
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. NM_001359202.1 → NP_001346131.1  ubiquitin-like protein 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AC157990, AC158302
      Conserved Domains (1) summary
      cl28922
      Location:1 → 47
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    5. NM_011908.2 → NP_036038.1  ubiquitin-like protein 3 isoform a

      See identical proteins and their annotated locations for NP_036038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK145952, AV226728, BU059122, CK794503, DV661495
      Consensus CDS
      CCDS39403.1
      UniProtKB/Swiss-Prot
      A4FTW0, Q3UKM1, Q9Z2M6
      UniProtKB/TrEMBL
      Q3UYL1
      Related
      ENSMUSP00000078303.8, ENSMUST00000079324.14
      Conserved Domains (1) summary
      cd17048
      Location:10 → 91
      Ubl_UBL3; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      148441441..148489689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504832.4 → XP_006504895.1  ubiquitin-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006504895.1

      UniProtKB/Swiss-Prot
      A4FTW0, Q3UKM1, Q9Z2M6
      UniProtKB/TrEMBL
      Q3UYL1
      Related
      ENSMUSP00000144073.2, ENSMUST00000201595.4
      Conserved Domains (1) summary
      cd17048
      Location:10 → 91
      Ubl_UBL3; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2M6.1 GenPept UniProtKB/Swiss-Prot:Q9Z2M6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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