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    Echdc2 enoyl Coenzyme A hydratase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 52430, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Echdc2provided by MGI
    Official Full Name
    enoyl Coenzyme A hydratase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1289238
    See related
    Ensembl:ENSMUSG00000028601 AllianceGenome:MGI:1289238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4Ertd765e; 1300017C12Rik; 2610009M20Rik
    Summary
    Predicted to enable lyase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; integumental system; peripheral nervous system; and sensory organ. Orthologous to human ECHDC2 (enoyl-CoA hydratase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 56.0), kidney adult (RPKM 55.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Echdc2 in Genome Data Viewer
    Location:
    4 C7; 4 50.3 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108022630..108036505)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108165436..108179308)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene sterol carrier protein 2, liver Neighboring gene microRNA 6397 Neighboring gene STARR-seq mESC enhancer starr_11030 Neighboring gene STARR-seq mESC enhancer starr_11031 Neighboring gene STARR-seq mESC enhancer starr_11032 Neighboring gene predicted gene, 54248 Neighboring gene zyg-11 family member A, cell cycle regulator Neighboring gene STARR-seq mESC enhancer starr_11034 Neighboring gene predicted gene, 54249 Neighboring gene zyg-ll family member B, cell cycle regulator Neighboring gene STARR-positive B cell enhancer ABC_E2701

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    2. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    enoyl-CoA hydratase domain-containing protein 2, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001254754.1 → NP_001241683.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001241683.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI839329, AK011365, AK166965, AL844206
      UniProtKB/Swiss-Prot
      Q3TLP5
      Conserved Domains (1) summary
      cl23717
      Location:1 → 191
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    2. NM_026728.4 → NP_081004.2  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_081004.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI839329, AK166965, AL844206
      Consensus CDS
      CCDS18447.2
      UniProtKB/Swiss-Prot
      A2APS6, Q3TKJ7, Q3TLP5, Q3TV08, Q3U553, Q8R3K4, Q9DBD3
      Related
      ENSMUSP00000051268.7, ENSMUST00000052999.13
      Conserved Domains (1) summary
      cl23717
      Location:42 → 296
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      108022630..108036505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320314.3 → XP_017175803.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q3TLP5
      Conserved Domains (1) summary
      cl23717
      Location:1 → 191
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    2. XM_011240573.3 → XP_011238875.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011238875.1

      UniProtKB/Swiss-Prot
      Q3TLP5
      Conserved Domains (1) summary
      cl23717
      Location:1 → 191
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    3. XM_036164235.1 → XP_036020128.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      Q8R3H3
      Conserved Domains (1) summary
      cl23717
      Location:1 → 161
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RNA

    1. XR_003954983.1 RNA Sequence

      Related
      ENSMUST00000125647.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TLP5.2 GenPept UniProtKB/Swiss-Prot:Q3TLP5

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