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    Npas3 neuronal PAS domain protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 27386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Npas3provided by MGI
    Official Full Name
    neuronal PAS domain protein 3provided by MGI
    Primary source
    MGI:MGI:1351610
    See related
    Ensembl:ENSMUSG00000021010 AllianceGenome:MGI:1351610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bHLHe12; 4930423H22Rik
    Summary
    Enables protein heterodimerization activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within locomotory behavior; maternal behavior; and startle response. Located in nucleus. Is expressed in several structures, including central nervous system; heart and pericardium; salivary gland; sensory organ; and urinary system. Orthologous to human NPAS3 (neuronal PAS domain protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 5.4), CNS E14 (RPKM 4.1) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Npas3 in Genome Data Viewer
    Location:
    12 C1; 12 22.31 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (53294874..54118956)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (53248026..54072173)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 6 Neighboring gene STARR-seq mESC enhancer starr_32141 Neighboring gene predicted gene, 53720 Neighboring gene predicted gene, 18898 Neighboring gene RIKEN cDNA 1700030L22 gene Neighboring gene STARR-seq mESC enhancer starr_32144 Neighboring gene STARR-seq mESC enhancer starr_32145 Neighboring gene predicted gene, 51419 Neighboring gene STARR-seq mESC enhancer starr_32146 Neighboring gene STARR-seq mESC enhancer starr_32148 Neighboring gene STARR-seq mESC enhancer starr_32149 Neighboring gene STARR-seq mESC enhancer starr_32150 Neighboring gene STARR-seq mESC enhancer starr_32151 Neighboring gene VISTA enhancer mm1188 Neighboring gene STARR-seq mESC enhancer starr_32152 Neighboring gene STARR-seq mESC enhancer starr_32153 Neighboring gene STARR-seq mESC enhancer starr_32154 Neighboring gene STARR-seq mESC enhancer starr_32155 Neighboring gene STARR-seq mESC enhancer starr_32156 Neighboring gene STARR-seq mESC enhancer starr_32157 Neighboring gene predicted gene, 35818 Neighboring gene predicted gene, 40424

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Npas3 regulates stemness maintenance of radial glial cells and neuronal migration in the developing mouse cerebral cortex. Liu JW, et al. Front Cell Neurosci, 2022. PMID 36313621, Free PMC Article
    2. Discovery of a proneurogenic, neuroprotective chemical. Pieper AA, et al. Cell, 2010 Jul 9. PMID 20603013, Free PMC Article
    3. Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. Brunskill EW, et al. Eur J Neurosci, 2005 Sep. PMID 16190882
    4. Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3. Sha L, et al. Mol Psychiatry, 2012 Mar. PMID 21709683
    5. Novel alternative splice variants of chicken NPAS3 are expressed in the developing central nervous system. Shin J, et al. Gene, 2013 Nov 10. PMID 23962688

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors.
      Title: Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors.
    2. Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions.
      Title: Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes.
    3. Most NPAS3 immunofluorescence originated in the subgranular zone of the dentate gyrus with immunopositive processes radiating into the granule cell layer proper. Npas3 acts during neuronal maturation/differentiation.
      Title: Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3.
    4. NPAS3 is a trachealess homolog critical for lung development and homeostasis.
      Title: NPAS3 is a trachealess homolog critical for lung development and homeostasis.
    5. Npas3-/- mice are deficient in expression of hippocampal FGF receptor subtype 1 mRNA.
      Title: The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.
    6. our observations indicate an important role for Npas3 in controlling normal brain development and neurosignaling pathways
      Title: Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice.
    7. a regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis
      Title: Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maternal behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within startle response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    neuronal PAS domain-containing protein 3
    Names
    basic-helix-loop-helix-PAS protein MOP6
    member of PAS protein 6
    neuronal PAS3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370960.1 → NP_001357889.1  neuronal PAS domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139934, BC120885, CT030137
      UniProtKB/TrEMBL
      A0A1Y7VJG5, Q0IJ77
      Related
      ENSMUSP00000152411.3, ENSMUST00000223358.3
      Conserved Domains (4) summary
      smart00091
      Location:158 → 216
      PAS; PAS domain
      pfam08447
      Location:349 → 436
      PAS_3; PAS fold
      NF012181
      Location:475 → 598
      MSCRAMM_SdrD; MSCRAMM family adhesin SdrD
      cd19732
      Location:53 → 130
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    2. NM_001370961.1 → NP_001357890.1  neuronal PAS domain-containing protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC120181, AC125451, AC139934, AC159634, CR974571, CT030137
      UniProtKB/TrEMBL
      F8VQB2
      Conserved Domains (4) summary
      smart00091
      Location:188 → 246
      PAS; PAS domain
      pfam08447
      Location:379 → 466
      PAS_3; PAS fold
      NF000535
      Location:466 → 631
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      cd19732
      Location:84 → 160
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    3. NM_001370962.1 → NP_001357891.1  neuronal PAS domain-containing protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC120181, AC125451, AC139934, AC159634, CR974571, CT030137
      UniProtKB/TrEMBL
      F8VQB2
      Conserved Domains (4) summary
      smart00091
      Location:186 → 244
      PAS; PAS domain
      pfam08447
      Location:377 → 464
      PAS_3; PAS fold
      NF012181
      Location:503 → 626
      MSCRAMM_SdrD; MSCRAMM family adhesin SdrD
      cd19732
      Location:84 → 160
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    4. NM_001370963.1 → NP_001357892.1  neuronal PAS domain-containing protein 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC120181, AC125451, AC139934, CR974571, CT030137
      UniProtKB/TrEMBL
      Q0IJ77
      Conserved Domains (4) summary
      smart00091
      Location:156 → 214
      PAS; PAS domain
      pfam08447
      Location:347 → 434
      PAS_3; PAS fold
      NF000535
      Location:434 → 599
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      cd19732
      Location:53 → 130
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    5. NM_001370964.1 → NP_001357893.1  neuronal PAS domain-containing protein 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC120181, AC125451, AC139934, AC159634, CR974571, CT030137
      UniProtKB/TrEMBL
      F8VQB2
      Conserved Domains (4) summary
      smart00091
      Location:203 → 261
      PAS; PAS domain
      pfam08447
      Location:394 → 481
      PAS_3; PAS fold
      NF000535
      Location:481 → 644
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      cd19732
      Location:84 → 160
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    6. NM_013780.3 → NP_038808.3  neuronal PAS domain-containing protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC139934, AF173871, CT030137
      Consensus CDS
      CCDS25907.1
      UniProtKB/TrEMBL
      F8VQB2
      Related
      ENSMUSP00000098975.3, ENSMUST00000101432.3
      Conserved Domains (4) summary
      smart00091
      Location:186 → 244
      PAS; PAS domain
      pfam08447
      Location:377 → 464
      PAS_3; PAS fold
      NF000535
      Location:464 → 629
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      cd19732
      Location:84 → 160
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      53294874..54118956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515941.4 → XP_006516004.1  neuronal PAS domain-containing protein 3 isoform X21

      UniProtKB/TrEMBL
      F8VQB2
      Conserved Domains (3) summary
      smart00091
      Location:205 → 263
      PAS; PAS domain
      pfam08447
      Location:396 → 483
      PAS_3; PAS fold
      cd19732
      Location:84 → 160
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    2. XM_030246748.2 → XP_030102608.1  neuronal PAS domain-containing protein 3 isoform X22

      UniProtKB/TrEMBL
      F8VQB2
      Conserved Domains (3) summary
      smart00091
      Location:203 → 261
      PAS; PAS domain
      pfam08447
      Location:394 → 481
      PAS_3; PAS fold
      cd19732
      Location:84 → 160
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    3. XM_006515942.4 → XP_006516005.1  neuronal PAS domain-containing protein 3 isoform X27

      UniProtKB/TrEMBL
      Q0IJ77
      Related
      ENSMUSP00000152452.2, ENSMUST00000223057.2
      Conserved Domains (3) summary
      smart00091
      Location:175 → 233
      PAS; PAS domain
      pfam08447
      Location:366 → 453
      PAS_3; PAS fold
      cd19732
      Location:53 → 130
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    4. XM_036157451.1 → XP_036013344.1  neuronal PAS domain-containing protein 3 isoform X28

      UniProtKB/TrEMBL
      Q0IJ77
      Conserved Domains (4) summary
      smart00091
      Location:173 → 231
      PAS; PAS domain
      pfam08447
      Location:364 → 451
      PAS_3; PAS fold
      cd19732
      Location:53 → 130
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033609
      Location:457 → 617
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    5. XM_036157450.1 → XP_036013343.1  neuronal PAS domain-containing protein 3 isoform X23

      UniProtKB/TrEMBL
      F8VQB2
      Conserved Domains (4) summary
      smart00091
      Location:203 → 261
      PAS; PAS domain
      pfam08447
      Location:394 → 481
      PAS_3; PAS fold
      cd19732
      Location:84 → 160
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:521 → 643
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    6. XM_030246749.2 → XP_030102609.1  neuronal PAS domain-containing protein 3 isoform X24

      UniProtKB/TrEMBL
      F8VQB2
      Conserved Domains (3) summary
      smart00091
      Location:188 → 246
      PAS; PAS domain
      pfam08447
      Location:379 → 466
      PAS_3; PAS fold
      cd19732
      Location:84 → 160
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    7. XM_030246750.2 → XP_030102610.1  neuronal PAS domain-containing protein 3 isoform X25

      UniProtKB/TrEMBL
      F8VQB2
      Conserved Domains (3) summary
      smart00091
      Location:186 → 244
      PAS; PAS domain
      pfam08447
      Location:377 → 464
      PAS_3; PAS fold
      cd19732
      Location:84 → 160
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    8. XM_030246751.2 → XP_030102611.1  neuronal PAS domain-containing protein 3 isoform X26

      UniProtKB/TrEMBL
      F8VQB2
      Conserved Domains (4) summary
      smart00091
      Location:188 → 246
      PAS; PAS domain
      pfam08447
      Location:379 → 466
      PAS_3; PAS fold
      NF012181
      Location:505 → 628
      MSCRAMM_SdrD; MSCRAMM family adhesin SdrD
      cd19732
      Location:84 → 160
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    9. XM_036157452.1 → XP_036013345.1  neuronal PAS domain-containing protein 3 isoform X29

      UniProtKB/TrEMBL
      Q0IJ77
      Conserved Domains (4) summary
      smart00091
      Location:158 → 216
      PAS; PAS domain
      pfam08447
      Location:349 → 436
      PAS_3; PAS fold
      cd19732
      Location:53 → 130
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033609
      Location:442 → 602
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    10. XM_036157455.1 → XP_036013348.1  neuronal PAS domain-containing protein 3 isoform X32

      UniProtKB/TrEMBL
      Q0IJ77
      Conserved Domains (4) summary
      smart00091
      Location:158 → 216
      PAS; PAS domain
      pfam08447
      Location:349 → 436
      PAS_3; PAS fold
      cd19732
      Location:53 → 130
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:476 → 599
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    11. XM_036157454.1 → XP_036013347.1  neuronal PAS domain-containing protein 3 isoform X31

      UniProtKB/TrEMBL
      Q0IJ77
      Conserved Domains (4) summary
      smart00091
      Location:156 → 214
      PAS; PAS domain
      pfam08447
      Location:347 → 434
      PAS_3; PAS fold
      cd19732
      Location:53 → 130
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033609
      Location:440 → 600
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    12. XM_036157453.1 → XP_036013346.1  neuronal PAS domain-containing protein 3 isoform X30

      UniProtKB/TrEMBL
      Q0IJ77
      Conserved Domains (4) summary
      smart00091
      Location:158 → 216
      PAS; PAS domain
      pfam08447
      Location:349 → 436
      PAS_3; PAS fold
      cd19732
      Location:53 → 130
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:476 → 601
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    13. XM_036157456.1 → XP_036013349.1  neuronal PAS domain-containing protein 3 isoform X33

      UniProtKB/TrEMBL
      Q0IJ77
      Conserved Domains (4) summary
      smart00091
      Location:156 → 214
      PAS; PAS domain
      pfam08447
      Location:347 → 434
      PAS_3; PAS fold
      cd19732
      Location:53 → 130
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:474 → 596
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    14. XM_030246754.2 → XP_030102614.1  neuronal PAS domain-containing protein 3 isoform X35

      UniProtKB/TrEMBL
      Q0IJ77
      Conserved Domains (4) summary
      smart00091
      Location:65 → 123
      PAS; PAS domain
      pfam08447
      Location:256 → 343
      PAS_3; PAS fold
      NF000535
      Location:377 → 500
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      cl00081
      Location:1 → 22
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    15. XM_036157459.1 → XP_036013352.1  neuronal PAS domain-containing protein 3 isoform X36

      UniProtKB/TrEMBL
      Q0IJ77
      Conserved Domains (4) summary
      smart00091
      Location:50 → 108
      PAS; PAS domain
      pfam08447
      Location:241 → 328
      PAS_3; PAS fold
      NF033609
      Location:334 → 494
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
      cl00081
      Location:1 → 22
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    16. XM_036157460.1 → XP_036013353.1  neuronal PAS domain-containing protein 3 isoform X38

      UniProtKB/TrEMBL
      Q0IJ77
      Conserved Domains (4) summary
      smart00091
      Location:48 → 106
      PAS; PAS domain
      pfam08447
      Location:239 → 326
      PAS_3; PAS fold
      NF033609
      Location:332 → 492
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
      cl00081
      Location:1 → 22
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    17. XM_036157458.1 → XP_036013351.1  neuronal PAS domain-containing protein 3 isoform X36

      UniProtKB/TrEMBL
      Q0IJ77
      Conserved Domains (4) summary
      smart00091
      Location:50 → 108
      PAS; PAS domain
      pfam08447
      Location:241 → 328
      PAS_3; PAS fold
      NF033609
      Location:334 → 494
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
      cl00081
      Location:1 → 22
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    18. XM_036157457.1 → XP_036013350.1  neuronal PAS domain-containing protein 3 isoform X34

      UniProtKB/TrEMBL
      A0A1Y7VM06
      Conserved Domains (4) summary
      smart00091
      Location:67 → 125
      PAS; PAS domain
      pfam08447
      Location:258 → 345
      PAS_3; PAS fold
      NF033609
      Location:351 → 511
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
      cl00081
      Location:1 → 22
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    19. XM_036157462.1 → XP_036013355.1  neuronal PAS domain-containing protein 3 isoform X40

      Conserved Domains (2) summary
      smart00091
      Location:461 → 499
      PAS; PAS domain
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    20. XM_036157463.1 → XP_036013356.1  neuronal PAS domain-containing protein 3 isoform X41

      Conserved Domains (2) summary
      smart00091
      Location:459 → 497
      PAS; PAS domain
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    21. XM_036157464.1 → XP_036013357.1  neuronal PAS domain-containing protein 3 isoform X42

      Conserved Domains (1) summary
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins

    22. XM_036157437.1 → XP_036013330.1  neuronal PAS domain-containing protein 3 isoform X1

      Conserved Domains (4) summary
      smart00091
      Location:478 → 536
      PAS; PAS domain
      pfam08447
      Location:669 → 756
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033609
      Location:762 → 922
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    23. XM_036157440.1 → XP_036013333.1  neuronal PAS domain-containing protein 3 isoform X5

      Conserved Domains (4) summary
      smart00091
      Location:478 → 536
      PAS; PAS domain
      pfam08447
      Location:669 → 756
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:796 → 919
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    24. XM_036157438.1 → XP_036013331.1  neuronal PAS domain-containing protein 3 isoform X3

      Conserved Domains (4) summary
      smart00091
      Location:476 → 534
      PAS; PAS domain
      pfam08447
      Location:667 → 754
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033609
      Location:760 → 920
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    25. XM_006515938.4 → XP_006516001.2  neuronal PAS domain-containing protein 3 isoform X2

      Conserved Domains (4) summary
      smart00091
      Location:478 → 536
      PAS; PAS domain
      pfam08447
      Location:669 → 756
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:796 → 921
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    26. XM_030246744.2 → XP_030102604.2  neuronal PAS domain-containing protein 3 isoform X6

      Conserved Domains (4) summary
      smart00091
      Location:478 → 536
      PAS; PAS domain
      pfam08447
      Location:669 → 756
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:796 → 918
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    27. XM_036157439.1 → XP_036013332.1  neuronal PAS domain-containing protein 3 isoform X4

      Conserved Domains (4) summary
      smart00091
      Location:476 → 534
      PAS; PAS domain
      pfam08447
      Location:667 → 754
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:794 → 919
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    28. XM_036157441.1 → XP_036013334.1  neuronal PAS domain-containing protein 3 isoform X7

      Conserved Domains (4) summary
      smart00091
      Location:476 → 534
      PAS; PAS domain
      pfam08447
      Location:667 → 754
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:794 → 916
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    29. XM_036157442.1 → XP_036013335.1  neuronal PAS domain-containing protein 3 isoform X8

      Conserved Domains (4) summary
      smart00091
      Location:461 → 519
      PAS; PAS domain
      pfam08447
      Location:652 → 739
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033609
      Location:745 → 905
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    30. XM_006515939.4 → XP_006516002.2  neuronal PAS domain-containing protein 3 isoform X9

      Conserved Domains (4) summary
      smart00091
      Location:461 → 519
      PAS; PAS domain
      pfam08447
      Location:652 → 739
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:779 → 904
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    31. XM_036157443.1 → XP_036013336.1  neuronal PAS domain-containing protein 3 isoform X12

      Conserved Domains (4) summary
      smart00091
      Location:461 → 519
      PAS; PAS domain
      pfam08447
      Location:652 → 739
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:779 → 902
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    32. XM_030246746.2 → XP_030102606.2  neuronal PAS domain-containing protein 3 isoform X13

      Conserved Domains (4) summary
      smart00091
      Location:461 → 519
      PAS; PAS domain
      pfam08447
      Location:652 → 739
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:779 → 901
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    33. XM_030246745.2 → XP_030102605.2  neuronal PAS domain-containing protein 3 isoform X10

      Conserved Domains (4) summary
      smart00091
      Location:459 → 517
      PAS; PAS domain
      pfam08447
      Location:650 → 737
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033609
      Location:743 → 903
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    34. XM_006515940.4 → XP_006516003.2  neuronal PAS domain-containing protein 3 isoform X11

      Conserved Domains (4) summary
      smart00091
      Location:459 → 517
      PAS; PAS domain
      pfam08447
      Location:650 → 737
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:777 → 902
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    35. XM_030246747.2 → XP_030102607.2  neuronal PAS domain-containing protein 3 isoform X14

      Conserved Domains (4) summary
      smart00091
      Location:459 → 517
      PAS; PAS domain
      pfam08447
      Location:650 → 737
      PAS_3; PAS fold
      cd19732
      Location:357 → 433
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:777 → 899
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    36. XM_036157444.1 → XP_036013337.1  neuronal PAS domain-containing protein 3 isoform X15

      Conserved Domains (4) summary
      smart00091
      Location:448 → 506
      PAS; PAS domain
      pfam08447
      Location:639 → 726
      PAS_3; PAS fold
      cd19732
      Location:326 → 403
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033609
      Location:732 → 892
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    37. XM_036157445.1 → XP_036013338.1  neuronal PAS domain-containing protein 3 isoform X16

      Conserved Domains (4) summary
      smart00091
      Location:446 → 504
      PAS; PAS domain
      pfam08447
      Location:637 → 724
      PAS_3; PAS fold
      cd19732
      Location:326 → 403
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033609
      Location:730 → 890
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    38. XM_036157446.1 → XP_036013339.1  neuronal PAS domain-containing protein 3 isoform X17

      Conserved Domains (4) summary
      smart00091
      Location:446 → 504
      PAS; PAS domain
      pfam08447
      Location:637 → 724
      PAS_3; PAS fold
      cd19732
      Location:326 → 403
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:764 → 886
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    39. XM_036157447.1 → XP_036013340.1  neuronal PAS domain-containing protein 3 isoform X18

      Conserved Domains (4) summary
      smart00091
      Location:431 → 489
      PAS; PAS domain
      pfam08447
      Location:622 → 709
      PAS_3; PAS fold
      cd19732
      Location:326 → 403
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033609
      Location:715 → 875
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    40. XM_036157448.1 → XP_036013341.1  neuronal PAS domain-containing protein 3 isoform X19

      Conserved Domains (4) summary
      smart00091
      Location:431 → 489
      PAS; PAS domain
      pfam08447
      Location:622 → 709
      PAS_3; PAS fold
      cd19732
      Location:326 → 403
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033845
      Location:749 → 874
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    41. XM_036157449.1 → XP_036013342.1  neuronal PAS domain-containing protein 3 isoform X20

      Conserved Domains (4) summary
      smart00091
      Location:429 → 487
      PAS; PAS domain
      pfam08447
      Location:620 → 707
      PAS_3; PAS fold
      cd19732
      Location:326 → 403
      bHLH-PAS_NPAS3_PASD6; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
      NF033609
      Location:713 → 873
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

    42. XM_030246752.2 → XP_030102612.1  neuronal PAS domain-containing protein 3 isoform X34

      UniProtKB/TrEMBL
      A0A1Y7VM06
      Conserved Domains (4) summary
      smart00091
      Location:67 → 125
      PAS; PAS domain
      pfam08447
      Location:258 → 345
      PAS_3; PAS fold
      NF033609
      Location:351 → 511
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
      cl00081
      Location:1 → 22
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    43. XM_030246756.2 → XP_030102616.1  neuronal PAS domain-containing protein 3 isoform X37

      UniProtKB/TrEMBL
      A0A1Y7VM06
      Conserved Domains (4) summary
      smart00091
      Location:50 → 108
      PAS; PAS domain
      pfam08447
      Location:241 → 328
      PAS_3; PAS fold
      NF000535
      Location:328 → 493
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      cl00081
      Location:1 → 22
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    44. XM_036157461.1 → XP_036013354.1  neuronal PAS domain-containing protein 3 isoform X39

      UniProtKB/TrEMBL
      A0A1Y7VM06
      Conserved Domains (4) summary
      smart00091
      Location:48 → 106
      PAS; PAS domain
      pfam08447
      Location:239 → 326
      PAS_3; PAS fold
      NF033845
      Location:366 → 491
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl00081
      Location:1 → 22
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZQ0.1 GenPept UniProtKB/Swiss-Prot:Q9QZQ0

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