Ikzf5 IKAROS family zinc finger 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ikzf5provided by MGI
Official Full Name: IKAROS family zinc finger 5provided by MGI
Primary source: MGI:MGI:1914393
See related: Ensembl:ENSMUSG00000040167 AllianceGenome:MGI:1914393
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PEGASUS; Zfpn1a5; 2610034F18Rik
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human IKZF5 (IKAROS family zinc finger 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 6.4), liver E14.5 (RPKM 5.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 73.98 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (130990378..131012243, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (131388649..131410518, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein Pegasus

Names: ikaros family zinc finger protein 5; zinc finger protein, subfamily 1A, 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418761.1 → NP_001405690.1 zinc finger protein Pegasus isoform 2

Status: VALIDATED

Source sequence(s)

AC156606
NM_001418762.1 → NP_001405691.1 zinc finger protein Pegasus isoform 3

Status: VALIDATED

Source sequence(s)

AC156606

Related

ENSMUSP00000113714.2, ENSMUST00000121033.8
NM_001418763.1 → NP_001405692.1 zinc finger protein Pegasus isoform 1

Status: VALIDATED

Source sequence(s)

AC156606

UniProtKB/Swiss-Prot

Q3U549, Q3USG0, Q8BU00, Q8BZR5
NM_175115.5 → NP_780324.2 zinc finger protein Pegasus isoform 1

See identical proteins and their annotated locations for NP_780324.2

Status: VALIDATED

Source sequence(s)

AC156606

Consensus CDS

CCDS21915.1

UniProtKB/Swiss-Prot

Q3U549, Q3USG0, Q8BU00, Q8BZR5

Related

ENSMUSP00000035583.9, ENSMUST00000046306.15

Conserved Domains (4) summary

sd00017
Location:84 → 104

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:366 → 393

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:124 → 148

zf-H2C2_2; Zinc-finger double domain

NF033913
Location:216 → 352

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

130990378..131012243 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153377.1 → XP_036009270.1 zinc finger protein Pegasus isoform X2

Conserved Domains (3) summary

sd00017
Location:45 → 65

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:57 → 81

zf-H2C2_2; Zinc-finger double domain

NF033913
Location:149 → 285

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
XM_036153376.1 → XP_036009269.1 zinc finger protein Pegasus isoform X1

UniProtKB/Swiss-Prot

Q3U549, Q3USG0, Q8BU00, Q8BZR5

Conserved Domains (4) summary

sd00017
Location:84 → 104

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:366 → 393

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:124 → 148

zf-H2C2_2; Zinc-finger double domain

NF033913
Location:216 → 352

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA