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    Thoc2 THO complex 2 [ Mus musculus (house mouse) ]

    Gene ID: 331401, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Thoc2provided by MGI
    Official Full Name
    THO complex 2provided by MGI
    Primary source
    MGI:MGI:2442413
    See related
    Ensembl:ENSMUSG00000037475 AllianceGenome:MGI:2442413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tho2; Gm1139; Gm1793; 6330441O12Rik; D130005M13Rik
    Summary
    Enables mRNA binding activity. Acts upstream of or within several processes, including blastocyst development; regulation of mRNA export from nucleus; and stem cell division. Located in nucleus. Is expressed in early conceptus and inner cell mass. Used to study X-linked intellectual disability-short stature-overweight syndrome. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 9.1), whole brain E14.5 (RPKM 9.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Thoc2 in Genome Data Viewer
    Location:
    X A4; X 23.19 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (40883869..41000878, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (41794992..41911937, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47054 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene mitogen-activated protein kinase associated protein 1 pseudogene Neighboring gene ribosomal protein S7 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Wang L, et al. Cell Stem Cell, 2013 Dec 5. PMID 24315442, Free PMC Article
    2. Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment. Bhattacharjee R, et al. Nat Commun, 2024 Feb 8. PMID 38331934, Free PMC Article
    3. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
    4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment.
      Title: Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in generation of neurons ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in generation of neurons ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of THO complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of THO complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 2
    Names
    transcription/export complex subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033422.1 → NP_001028594.1  THO complex subunit 2

      See identical proteins and their annotated locations for NP_001028594.1

      Status: VALIDATED

      Source sequence(s)
      AK031896, AK051141, AK138023, AK140950, CF423635, CN537042, CO045267, CX203600, CX213978
      Consensus CDS
      CCDS40951.1
      UniProtKB/Swiss-Prot
      B1AZI6
      Related
      ENSMUSP00000044677.9, ENSMUST00000047037.15
      Conserved Domains (3) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:11 → 566
      THOC2_N; THO complex subunit 2 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      40883869..41000878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541503.5 → XP_006541566.1  THO complex subunit 2 isoform X1

      Conserved Domains (4) summary
      TIGR01622
      Location:1475 → 1532
      SF-CC1; splicing factor, CC1-like family
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:11 → 566
      THOC2_N; THO complex subunit 2 N-terminus

    2. XM_036161990.1 → XP_036017883.1  THO complex subunit 2 isoform X2

      Conserved Domains (4) summary
      TIGR01622
      Location:1396 → 1453
      SF-CC1; splicing factor, CC1-like family
      pfam11262
      Location:795 → 1094
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:489 → 563
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:3 → 487
      THOC2_N; THO complex subunit 2 N-terminus

    RNA

    1. XR_001782751.3 RNA Sequence

    2. XR_004940344.1 RNA Sequence

    3. XR_003953012.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AZI6.1 GenPept UniProtKB/Swiss-Prot:B1AZI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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