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    Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 231872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aimp2provided by MGI
    Official Full Name
    aminoacyl tRNA synthetase complex-interacting multifunctional protein 2provided by MGI
    Primary source
    MGI:MGI:2385237
    See related
    Ensembl:ENSMUSG00000029610 AllianceGenome:MGI:2385237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jtv1; Aimp2(p38)
    Summary
    Enables molecular adaptor activity. Involved in protein-containing complex assembly. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of protein ubiquitination; and type II pneumocyte differentiation. Located in nucleus. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including olfactory epithelium; orbito-sphenoid; submandibular gland primordium; thymus primordium; and tooth. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 17. Orthologous to human AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 41.7), liver E14.5 (RPKM 30.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aimp2 in Genome Data Viewer
    Location:
    5 G2; 5 82.8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143839522..143846657, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143902704..143909839, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D130017N08 gene Neighboring gene STARR-positive B cell enhancer ABC_E10364 Neighboring gene STARR-positive B cell enhancer ABC_E2182 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene STARR-positive B cell enhancer ABC_E858 Neighboring gene PMS1 homolog2, mismatch repair system component Neighboring gene CCZ1 vacuolar protein trafficking and biogenesis associated Neighboring gene STARR-positive B cell enhancer ABC_E6396 Neighboring gene predicted gene, 24311 Neighboring gene predicted gene, 54312 Neighboring gene predicted gene, 33427

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis. Choi JW, et al. Carcinogenesis, 2009 Sep. PMID 19622630
    2. Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death. Kook MG, et al. Mol Neurobiol, 2023 Jan. PMID 36242734
    3. Comparative proteomic profiling reveals a pathogenic role for the O-GlcNAcylated AIMP2-PARP1 complex in aging-related hepatic steatosis in mice. Li R, et al. FEBS Lett, 2022 Jan. PMID 34817071
    4. Autophagy-mediated clearance of aggresomes is not a universal phenomenon. Wong ES, et al. Hum Mol Genet, 2008 Aug 15. PMID 18502787, Free PMC Article
    5. Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression. Oh AY, et al. Cancer Res, 2016 Aug 15. PMID 27302160

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparative proteomic profiling reveals a pathogenic role for the O-GlcNAcylated AIMP2-PARP1 complex in aging-related hepatic steatosis in mice.
      Title: Comparative proteomic profiling reveals a pathogenic role for the O-GlcNAcylated AIMP2-PARP1 complex in aging-related hepatic steatosis in mice.
    2. Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death.
      Title: Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death.
    3. our findings show how DX2 promotes lung cancer progression and how its activity may be thwarted as a strategy to treat patients with lung cancers exhibiting elevated DX2 levels
      Title: Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression.
    4. functional significance of AIMP2 in determination of cell proliferation and death, and as a haploinsufficient tumor suppressor.
      Title: Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30261, MGC36346, MGC36522, MGC37389

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within type II pneumocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Names
    ARS interacting multifunctional protein 2
    multisynthase complex auxiliary component p38
    multisynthetase complex auxiliary component p38
    protein JTV-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172146.1 → NP_001165617.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001165617.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BY202241, CF732613, CX566811
      Consensus CDS
      CCDS51692.1
      UniProtKB/Swiss-Prot
      E9QP67, Q8R010, Q8R2Y6
      Related
      ENSMUSP00000031613.5, ENSMUST00000031613.11
      Conserved Domains (2) summary
      cd03200
      Location:214 → 309
      GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
      pfam16780
      Location:1 → 33
      AIMP2_LysRS_bd; AIMP2 lysyl-tRNA synthetase binding domain

    2. NM_146165.2 → NP_666277.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform 2

      See identical proteins and their annotated locations for NP_666277.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment near the N-terminus, compared to isoform 1.
      Source sequence(s)
      BY202241, CJ051555, CX566811
      Consensus CDS
      CCDS39374.1
      UniProtKB/TrEMBL
      Q8R3V2
      Related
      ENSMUSP00000098052.3, ENSMUST00000100483.3
      Conserved Domains (1) summary
      cd03200
      Location:174 → 269
      GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143839522..143846657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R010.2 GenPept UniProtKB/Swiss-Prot:Q8R010

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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