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    Plppr3 phospholipid phosphatase related 3 [ Mus musculus (house mouse) ]

    Gene ID: 216152, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plppr3provided by MGI
    Official Full Name
    phospholipid phosphatase related 3provided by MGI
    Primary source
    MGI:MGI:2388640
    See related
    Ensembl:ENSMUSG00000035835 AllianceGenome:MGI:2388640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prg2; Lppr3
    Summary
    Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system and sensory organ. Orthologous to human PLPPR3 (phospholipid phosphatase related 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 149.6), CNS E14 (RPKM 137.8) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plppr3 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79696309..79710948, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79860475..79874958, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mitotic spindle positioning Neighboring gene RIKEN cDNA E130317F20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79314980-79315089 Neighboring gene polypyrimidine tract binding protein 1 Neighboring gene microRNA 6910 Neighboring gene proteinase 3 Neighboring gene elastase, neutrophil expressed

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury. Broggini T, et al. Aging (Albany NY), 2016 Oct 15. PMID 27744421, Free PMC Article
    2. Systematic expression analysis of plasticity-related genes in mouse brain development brings PRG4 into play. Gross I, et al. Dev Dyn, 2022 Apr. PMID 34622503
    3. TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis. Yaguchi H, et al. J Biol Chem, 2012 Apr 6. PMID 22337885, Free PMC Article
    4. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Bräuer AU, et al. Nat Neurosci, 2003 Jun. PMID 12730698
    5. Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. Cheng J, et al. Neuron, 2016 Oct 5. PMID 27641493, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4076

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid phosphatase-related protein type 3
    Names
    PRG-2
    inactive phospholipid phosphatase PLPPR3
    lipid phosphate phosphatase-related protein type 3
    plasticity related gene 2
    plasticity-related gene 2 protein
    NP_001164406.1
    NP_001408352.1
    NP_001408353.1
    NP_001408354.1
    NP_001408355.1
    NP_001408358.1
    NP_001408359.1
    NP_001408360.1
    NP_859009.2
    XP_030100879.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170935.1 → NP_001164406.1  phospholipid phosphatase-related protein type 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF541278, BC098099
      Consensus CDS
      CCDS48622.1
      UniProtKB/TrEMBL
      E9QAX3
      Related
      ENSMUSP00000130695.2, ENSMUST00000167250.8
      Conserved Domains (1) summary
      cd03384
      Location:127 → 276
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    2. NM_001421423.1 → NP_001408352.1  phospholipid phosphatase-related protein type 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC151846
      UniProtKB/Swiss-Prot
      Q4V781, Q68FN2, Q6NZQ9, Q7TPB0
      UniProtKB/TrEMBL
      A0A0R3P9D0

    3. NM_001421424.1 → NP_001408353.1  phospholipid phosphatase-related protein type 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC151846
      UniProtKB/Swiss-Prot
      Q4V781, Q68FN2, Q6NZQ9, Q7TPB0
      UniProtKB/TrEMBL
      A0A0R3P9D0
      Related
      ENSMUST00000113452.9

    4. NM_001421425.1 → NP_001408354.1  phospholipid phosphatase-related protein type 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC151846
      UniProtKB/Swiss-Prot
      Q4V781, Q68FN2, Q6NZQ9, Q7TPB0
      UniProtKB/TrEMBL
      A0A0R3P9D0

    5. NM_001421426.1 → NP_001408355.1  phospholipid phosphatase-related protein type 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC151846
      UniProtKB/Swiss-Prot
      Q4V781, Q68FN2, Q6NZQ9, Q7TPB0

    6. NM_001421429.1 → NP_001408358.1  phospholipid phosphatase-related protein type 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC151846
      UniProtKB/Swiss-Prot
      Q4V781, Q68FN2, Q6NZQ9, Q7TPB0

    7. NM_001421430.1 → NP_001408359.1  phospholipid phosphatase-related protein type 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC151846
      UniProtKB/Swiss-Prot
      Q4V781, Q68FN2, Q6NZQ9, Q7TPB0

    8. NM_001421431.1 → NP_001408360.1  phospholipid phosphatase-related protein type 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC151846
      UniProtKB/TrEMBL
      Q5DTP6

    9. NM_181681.3 → NP_859009.2  phospholipid phosphatase-related protein type 3 isoform 1

      See identical proteins and their annotated locations for NP_859009.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC151846
      Consensus CDS
      CCDS35971.1
      UniProtKB/Swiss-Prot
      Q4V781, Q68FN2, Q6NZQ9, Q7TPB0
      UniProtKB/TrEMBL
      A0A0R3P9D0
      Related
      ENSMUSP00000089979.5, ENSMUST00000092325.11
      Conserved Domains (1) summary
      cd03384
      Location:127 → 276
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RNA

    1. NR_033210.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF541278, AK220474, BC079534
      Related
      ENSMUST00000166057.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79696309..79710948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245019.2 → XP_030100879.1  phospholipid phosphatase-related protein type 3 isoform X1

      UniProtKB/Swiss-Prot
      Q4V781, Q68FN2, Q6NZQ9, Q7TPB0
      UniProtKB/TrEMBL
      A0A0R3P9D0
      Conserved Domains (1) summary
      cd03384
      Location:127 → 276
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPB0.1 GenPept UniProtKB/Swiss-Prot:Q7TPB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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