Hkdc1 hexokinase domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hkdc1provided by MGI
Official Full Name: hexokinase domain containing 1provided by MGI
Primary source: MGI:MGI:2384910
See related: Ensembl:ENSMUSG00000020080 AllianceGenome:MGI:2384910
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable fructokinase activity and glucokinase activity. Involved in intracellular glucose homeostasis. Located in photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human HKDC1 (hexokinase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 26.1), small intestine adult (RPKM 24.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.4 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (62218916..62259490, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (62383137..62423711, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.
Title: HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.
Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice.
Title: Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice.
Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.
Title: Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.
The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy.
Title: The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy.
expression in hepatocytes results in defective mitochondrial function and altered hepatocellular metabolism
Title: Hepatic HKDC1 Expression Contributes to Liver Metabolism.
Hepatic HKDC1 contributes to whole body glucose disposal, insulin sensitivity, and aspects of nutrient balance during pregnancy.
Title: Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice.
Taken together, our data demonstrated that HKDC1 is associated with autosomal recessively inherited Retinitis pigmentosa.
Title: Whole-exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables D-glucose binding	IEA Inferred from Electronic Annotation more info
enables fructokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucokinase activity	ISO Inferred from Sequence Orthology more info
enables glucokinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in carbohydrate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glucose 6-phosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in hexose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular glucose homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hexokinase HKDC1

Names: hexokinase domain-containing protein 1; putative hexokinase HKDC1

NP_663394.1

EC 2.7.1.1

XP_011241699.1

EC 2.7.1.1

XP_011241700.1

EC 2.7.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145419.1 → NP_663394.1 hexokinase HKDC1

See identical proteins and their annotated locations for NP_663394.1

Status: PROVISIONAL

Source sequence(s)

BC016235

Consensus CDS

CCDS23888.1

UniProtKB/Swiss-Prot

Q3UKJ9, Q91W97

Related

ENSMUSP00000020277.9, ENSMUST00000020277.9

Conserved Domains (3) summary

PTZ00107
Location:466 → 905

PTZ00107; hexokinase; Provisional

pfam00349
Location:21 → 219

Hexokinase_1

pfam03727
Location:225 → 459

Hexokinase_2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

62218916..62259490 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243398.4 → XP_011241700.1 hexokinase HKDC1 isoform X2

Conserved Domains (2) summary

pfam00349
Location:229 → 424

Hexokinase_1

pfam03727
Location:430 → 664

Hexokinase_2
XM_011243397.3 → XP_011241699.1 hexokinase HKDC1 isoform X1

Conserved Domains (2) summary

pfam00349
Location:469 → 664

Hexokinase_1

pfam03727
Location:225 → 459

Hexokinase_2