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Erbb4 erb-b2 receptor tyrosine kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59323, updated on 9-Dec-2024

Summary

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Official Symbol: Erbb4provided by RGD
Official Full Name: erb-b2 receptor tyrosine kinase 4provided by RGD
Primary source: RGD:620486
See related: EnsemblRapid:ENSRNOG00000014248 AllianceGenome:RGD:620486
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables neuregulin receptor activity. Involved in several processes, including cellular response to L-glutamate; modulation of chemical synaptic transmission; and nervous system development. Located in several cellular components, including caveola; postsynaptic density; and postsynaptic membrane. Is active in plasma membrane. Used to study visual epilepsy. Biomarker of several diseases, including amblyopia; bipolar disorder; interstitial cystitis; median neuropathy; and radiculopathy. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 139.1), Kidney (RPKM 128.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Erbb4 in Genome Data Viewer

Location:: 9q32-q33

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (76973386..78045633, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (69523733..70596743, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (75021790..76178936, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPbeta modification in rats.
Title: MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPβ modification in rats.
MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats.
Title: MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats.
Effect of regulation of the NRG1/ErbB4 signaling pathway on the visual cortex synaptic plasticity of amblyopic adult rats.
Title: Effect of regulation of the NRG1/ErbB4 signaling pathway on the visual cortex synaptic plasticity of amblyopic adult rats.
These data suggest that the S100-ErbB axis may be an important mechanism regulating neuronal survival and plasticity.
Title: The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival.
It is a member of the receptor tyrosine kinase family, plays critical roles in development and function of neural circuitry, relevant to behavioral deficits.
Title: High glucose forces a positive feedback loop connecting ErbB4 expression and mTOR/S6K pathway to aggravate the formation of tau hyperphosphorylation in differentiated SH-SY5Y cells.
ErbB4 plays a neuroprotective role in early brain injury after subarachnoid hemorrhage.
Title: ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage.
The Paracrine Effect of Skeletal Myoblasts Is Cardioprotective Against Oxidative Stress and Involves EGFR-ErbB4 Signaling, Cystathionase, and the Unfolded Protein Response
Title: The Paracrine Effect of Skeletal Myoblasts Is Cardioprotective Against Oxidative Stress and Involves EGFR-ErbB4 Signaling, Cystathionase, and the Unfolded Protein Response.
NRG-1, ErbB2, and ErbB4 expression significantly decreased in vein grafts over time.
Title: The Significance of Neuregulin-1/ErbB Expression in Autogenous Vein Grafts in a Diabetic Rat Model.
Findings reveal an intimate reciprocal relationship between ErbB4 and GluN2b NMDA receptors via NRG2/ErbB4 signaling.
Title: A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
Exercise training and return to a well-balanced diet activate the neuregulin 1/ErbB pathway in skeletal muscle of obese rats
Title: Exercise training and return to a well-balanced diet activate the neuregulin 1/ErbB pathway in skeletal muscle of obese rats.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Erbb4 (e-PCR), detects polymorphism
- UniSTS:468004

AU049543 (e-PCR)
- UniSTS:145990

Erbb4 (e-PCR), detects polymorphism
- UniSTS:143005

D9Got77 (e-PCR)
- UniSTS:112833

D9Got74 (e-PCR)
- UniSTS:114658

D9Rat174 (e-PCR)
- UniSTS:228351

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GABA receptor binding	IEA Inferred from Electronic Annotation more info
enables GABA receptor binding	ISO Inferred from Sequence Orthology more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables epidermal growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables neuregulin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuregulin receptor activity	IEA Inferred from Electronic Annotation more info
enables neuregulin receptor activity	ISO Inferred from Sequence Orthology more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERBB signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERBB2-ERBB4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERBB2-ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB4-ERBB4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERBB4-ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle tissue regeneration	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to acetylcholine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in central nervous system morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in central nervous system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in central nervous system morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in embryonic pattern specification	IEA Inferred from Electronic Annotation more info
involved_in embryonic pattern specification	ISO Inferred from Sequence Orthology more info
involved_in embryonic pattern specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in establishment of planar polarity involved in nephron morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of planar polarity involved in nephron morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in lactation	ISO Inferred from Sequence Orthology more info
involved_in lactation	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mammary gland alveolus development	IEA Inferred from Electronic Annotation more info
involved_in mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
involved_in mammary gland alveolus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in mammary gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mammary gland epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in mammary gland epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in mammary gland epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial fragmentation involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fragmentation involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fragmentation involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron migration	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest cell migration	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell migration	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in olfactory bulb interneuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in olfactory bulb interneuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in olfactory bulb interneuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendritic spine maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell surface	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell communication	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of signaling	IEA Inferred from Electronic Annotation more info
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telencephalon development	IEP Inferred from Expression Pattern more info	PubMed
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in basal plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor tyrosine-protein kinase erbB-4

Names: c-erbB-4; proto-oncogene-like protein c-ErbB-4; receptor tyrosine kinase; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene 4

NP_067719.2

EC 2.7.10.1

XP_038940077.1

EC 2.7.10.1

XP_038940078.1

EC 2.7.10.1

XP_038940079.1

EC 2.7.10.1

XP_063123732.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021687.2 → NP_067719.2 receptor tyrosine-protein kinase erbB-4 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q62956, Q6UA28, Q6UA29, Q9Z2N7

UniProtKB/TrEMBL

A0A8I6AIL0, A6KFE7

Related

ENSRNOP00000092891.1, ENSRNOT00000118754.2

Conserved Domains (5) summary

cd05110
Location:710 → 1012

PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4

cd12092
Location:642 → 685

TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase

pfam00757
Location:186 → 332

Furin-like; Furin-like cysteine rich region

pfam01030
Location:55 → 167

Recep_L_domain; Receptor L domain

pfam14843
Location:502 → 634

GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

76973386..78045633 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267662.1 → XP_063123732.1 receptor tyrosine-protein kinase erbB-4 isoform X3

UniProtKB/Swiss-Prot

Q62956, Q6UA28, Q6UA29, Q9Z2N7

Related

ENSRNOP00000097510.2, ENSRNOT00000100527.2
XM_039084150.2 → XP_038940078.1 receptor tyrosine-protein kinase erbB-4 isoform X2

UniProtKB/Swiss-Prot

Q62956, Q6UA28, Q6UA29, Q9Z2N7

UniProtKB/TrEMBL

A0A8I6GMJ5

Conserved Domains (5) summary

cd05110
Location:710 → 1012

PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4

cd12092
Location:642 → 685

TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase

pfam00757
Location:186 → 332

Furin-like; Furin-like cysteine rich region

pfam01030
Location:55 → 167

Recep_L_domain; Receptor L domain

pfam14843
Location:502 → 634

GF_recep_IV; Growth factor receptor domain IV
XM_039084151.2 → XP_038940079.1 receptor tyrosine-protein kinase erbB-4 isoform X4

UniProtKB/Swiss-Prot

Q62956, Q6UA28, Q6UA29, Q9Z2N7

Conserved Domains (5) summary

cd05110
Location:700 → 1002

PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4

cd12092
Location:632 → 675

TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase

pfam00757
Location:186 → 332

Furin-like; Furin-like cysteine rich region

pfam01030
Location:55 → 167

Recep_L_domain; Receptor L domain

pfam14843
Location:502 → 634

GF_recep_IV; Growth factor receptor domain IV
XM_039084149.2 → XP_038940077.1 receptor tyrosine-protein kinase erbB-4 isoform X1

UniProtKB/Swiss-Prot

Q62956, Q6UA28, Q6UA29, Q9Z2N7

UniProtKB/TrEMBL

A0A8I6AGX1

Related

ENSRNOP00000092095.1, ENSRNOT00000103925.2

Conserved Domains (5) summary

cd05110
Location:700 → 1002

PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4

cd12092
Location:632 → 675

TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase

pfam00757
Location:186 → 332

Furin-like; Furin-like cysteine rich region

pfam01030
Location:55 → 167

Recep_L_domain; Receptor L domain

pfam14843
Location:502 → 634

GF_recep_IV; Growth factor receptor domain IV