Mdh2 malate dehydrogenase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mdh2provided by RGD
Official Full Name: malate dehydrogenase 2provided by RGD
Primary source: RGD:619719
See related: EnsemblRapid:ENSRNOG00000001440 AllianceGenome:RGD:619719
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mor1
Summary: Enables L-malate dehydrogenase (NAD+) activity; L-malate dehydrogenase (NADP+) activity; and identical protein binding activity. Involved in NADH metabolic process and malate metabolic process. Located in mitochondrial matrix. Used to study brain ischemia; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 2006.1), Muscle (RPKM 1403.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (26530886..26543841, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (20894269..20907225, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (23941451..23954406, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results indicate an alteration in the energy metabolism in hippocampus and striatum of infant rats after acute administration of l-tyrosine.
Title: Acute administration of l-tyrosine alters energetic metabolism of hippocampus and striatum of infant rats.
L-2-hydroxyglutarate accumulates as a result of a deficiency in FAD-linked L-2-hydroxyglutarate dehydrogenase. mitochondrial L-malate dehydrogenase is responsible for the excretion of L-2-hydroxyglutarate in this condition.
Title: L-2-hydroxyglutaric aciduria, a defect of metabolite repair.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142438 (e-PCR)
- UniSTS:231685

D12Wox10 (e-PCR)
- UniSTS:118039

RH127736 (e-PCR)
- UniSTS:211046

BM390639 (e-PCR)
- UniSTS:260834

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-malate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-malate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables L-malate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables L-malate dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables L-malate dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables malate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NADH metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in malate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in malate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in malate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in malate-aspartate shuttle	IEA Inferred from Electronic Annotation more info
involved_in malate-aspartate shuttle	ISO Inferred from Sequence Orthology more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: malate dehydrogenase, mitochondrial

Names: malate dehydrogenase 2, NAD (mitochondrial)

NP_112413.2

EC 1.1.1.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031151.3 → NP_112413.2 malate dehydrogenase, mitochondrial precursor

See identical proteins and their annotated locations for NP_112413.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P04636, Q6GSM4

UniProtKB/TrEMBL

A0A8I6ABC9, A6J0B0

Related

ENSRNOP00000001958.2, ENSRNOT00000001958.6

Conserved Domains (2) summary

TIGR01772
Location:26 → 335

MDH_euk_gproteo; malate dehydrogenase, NAD-dependent

cd01337
Location:26 → 334

MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases