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    Pabpc4 poly(A) binding protein, cytoplasmic 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298510, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pabpc4provided by RGD
    Official Full Name
    poly(A) binding protein, cytoplasmic 4provided by RGD
    Primary source
    RGD:1305015
    See related
    EnsemblRapid:ENSRNOG00000015642 AllianceGenome:RGD:1305015
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to act upstream of or within myeloid cell development and regulation of mRNA stability. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Orthologous to human PABPC4 (poly(A) binding protein cytoplasmic 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 482.2), Heart (RPKM 321.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pabpc4 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (140847835..140864089)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135563142..135578985)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (140978893..140994732)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase, cytosolic IA Neighboring gene uncharacterized LOC108351027 Neighboring gene hes-related family bHLH transcription factor with YRPW motif-like Neighboring gene small nucleolar RNA SNORA55 Neighboring gene small nucleolar RNA SNORA55 Neighboring gene bone morphogenetic protein 8a Neighboring gene 3-oxoacid CoA transferase 2A Neighboring gene ribosomal protein S14, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation. Kini HK, et al. Mol Cell Biol, 2014 Apr. PMID 24469397, Free PMC Article
    2. iPABP, an inducible poly(A)-binding protein detected in activated human T cells. Yang H, et al. Mol Cell Biol, 1995 Dec. PMID 8524242, Free PMC Article
    3. Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs. Burgess HM, et al. J Cell Sci, 2011 Oct 1. PMID 21940797, Free PMC Article
    4. Molecular composition of IMP1 ribonucleoprotein granules. Jønson L, et al. Mol Cell Proteomics, 2007 May. PMID 17289661
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables poly(C) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within myeloid cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polyadenylate-binding protein 4
    Names
    poly(A) binding protein, cytoplasmic 4 (inducible form)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100538.1 → NP_001094008.1  polyadenylate-binding protein 4

      See identical proteins and their annotated locations for NP_001094008.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166452
      UniProtKB/TrEMBL
      A0A8J8XGC4, A6IS24
      Conserved Domains (6) summary
      TIGR01628
      Location:11 → 624
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:12 → 91
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:97 → 172
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:190 → 269
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:293 → 370
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:556 → 623
      PABP; Poly-adenylate binding protein, unique domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      140847835..140864089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238799.4 → XP_006238861.1  polyadenylate-binding protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006238861.1

      UniProtKB/TrEMBL
      A6IS24, A6IS25
      Conserved Domains (6) summary
      TIGR01628
      Location:11 → 640
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:12 → 91
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:97 → 172
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:190 → 269
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:293 → 370
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:572 → 639
      PABP; Poly-adenylate binding protein, unique domain

    2. XM_039109613.2 → XP_038965541.1  polyadenylate-binding protein 4 isoform X5

      UniProtKB/TrEMBL
      A6IS24
      Conserved Domains (1) summary
      TIGR01628
      Location:11 → 611
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    3. XM_063287433.1 → XP_063143503.1  polyadenylate-binding protein 4 isoform X3

    4. XM_063287434.1 → XP_063143504.1  polyadenylate-binding protein 4 isoform X7

    5. XM_006238798.4 → XP_006238860.1  polyadenylate-binding protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006238860.1

      UniProtKB/TrEMBL
      A6IS24, A6IS26, B2GUY3, G3V9N0
      Related
      ENSRNOP00000053432.4, ENSRNOT00000056592.5
      Conserved Domains (6) summary
      TIGR01628
      Location:11 → 640
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:12 → 91
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:97 → 172
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:190 → 269
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:293 → 370
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:572 → 639
      PABP; Poly-adenylate binding protein, unique domain

    6. XM_006238800.4 → XP_006238862.1  polyadenylate-binding protein 4 isoform X4

      UniProtKB/TrEMBL
      A6IS24
      Related
      ENSRNOP00000090731.2, ENSRNOT00000106428.2
      Conserved Domains (6) summary
      TIGR01628
      Location:11 → 611
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:12 → 91
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:97 → 172
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:190 → 269
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:293 → 370
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:543 → 610
      PABP; Poly-adenylate binding protein, unique domain

    7. XM_006238801.4 → XP_006238863.1  polyadenylate-binding protein 4 isoform X6

      UniProtKB/TrEMBL
      A6IS24
      Conserved Domains (6) summary
      TIGR01628
      Location:11 → 595
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:12 → 91
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:97 → 172
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:190 → 269
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:293 → 370
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:527 → 594
      PABP; Poly-adenylate binding protein, unique domain

    8. XM_039109614.2 → XP_038965542.1  polyadenylate-binding protein 4 isoform X8

      UniProtKB/TrEMBL
      Q5I0G7
      Conserved Domains (1) summary
      TIGR01628
      Location:1 → 418
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    Nucleotide Protein Strain
    Heading Accession and Version

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