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Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25513, updated on 9-Dec-2024

Summary

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Official Symbol: Pik3r1provided by RGD
Official Full Name: phosphoinositide-3-kinase regulatory subunit 1provided by RGD
Primary source: RGD:3329
See related: EnsemblRapid:ENSRNOG00000018903 AllianceGenome:RGD:3329
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PI3KA
Summary: Enables several functions, including 1-phosphatidylinositol-3-kinase regulator activity; calmodulin binding activity; and enzyme binding activity. Contributes to 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; regulation of protein metabolic process; and response to dexamethasone. Part of phosphatidylinositol 3-kinase complex. Used to study hypertension and portal hypertension. Biomarker of hepatocellular carcinoma; hypertension; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; agammaglobulinemia 7; astroblastoma; endometrial cancer (multiple); and immunodeficiency 36. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 301.4), Lung (RPKM 250.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Pik3r1 in Genome Data Viewer

Location:: 2q12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (34612946..34697660, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (32878942..32963668, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (31742326..31826882, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiRNA-1 promotes pyroptosis of cardiomyocytes and release of inflammatory factors by downregulating the expression level of PIK3R1 through the FoxO3a pathway.
Title: MiRNA-1 promotes pyroptosis of cardiomyocytes and release of inflammatory factors by downregulating the expression level of PIK3R1 through the FoxO3a pathway.
Its downregulation may be involved in the development of sex hormone disorder and calcium loss.
Title: Exogenous leptin administered intramuscularly induces sex hormone disorder and Ca loss via downregulation of Gnrh and PI3K expression.
glucose induces apoptosis and inhibits proliferation of glial cells, which may be mediated by the phosphorylation of tuberin, down regulation of 8-oxoG-DNA glycosylase and 8-hydroxydeoxyguanosine accumulation via activation of Akt and ERK1/2MAPK pathways.
Title: Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells.
Phosphorylation of PI3K is inhibited during brain development following BIG1 depletion.
Title: BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K-AKT and ERK signaling pathways.
PI3K activity is required for gastric mucosal inflammatory responses to Helicobacter pylori.
Title: Role of ghrelin-induced phosphatidylinositol 3-kinase activation in modulation of gastric mucosal inflammatory responses to Helicobacter pylori.
Phosphatidylinositol 3'-kinase is increased in heart tissue following exercise training in experimental diabetes.
Title: Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats.
Significant increases in IR b-subunit, IRS-1 and PTP1B protein contents were seen in the hearts of low protein diet group, also GLUT4 and PI3-kinase protein levels were markedly increased.
Title: Adverse cardiac remodeling due to maternal low protein diet is associated with alterations in expression of genes regulating glucose metabolism.
Data suggest that NRG-1beta could prevents Ca(2+) overload and apoptosis by activating PI3K/Akt pathway of primary cultured DRG neurons with excitotoxicity induced by glutamate.
Title: Neuregulin-1β prevents Ca(2+) overloading and apoptosis through PI3K/Akt activation in cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate.
Results show that ANGPT1 alters steroidogenesis, reduces ovarian apoptosis, and stimulates cell proliferation in antral follicles, and may exert these roles through the PI3K/AKT pathway.
Title: Angiopoietin 1 reduces rat follicular atresia mediated by apoptosis through the PI3K/Akt pathway.
the PI3K-Akt and MEK-ERK signalling cascades have distinct roles in the up-regulation of P2X(4)R expression in microglia at transcriptional and post-transcriptional levels
Title: Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138083 (e-PCR)
- UniSTS:220170

Pik3r1 (e-PCR), detects polymorphism
- UniSTS:144181

RH138178 (e-PCR)
- UniSTS:220265

U50413 (e-PCR)
- UniSTS:180592

BF390857 (e-PCR)
- UniSTS:249590

RH94812 (e-PCR)
- UniSTS:120058

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to 1-phosphatidylinositol-3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	TAS Traceable Author Statement more info	PubMed
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-3-kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ErbB-3 class receptor binding	IEA Inferred from Electronic Annotation more info
enables ErbB-3 class receptor binding	ISO Inferred from Sequence Orthology more info
enables ErbB-3 class receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin binding	IEA Inferred from Electronic Annotation more info
enables insulin binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor substrate binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin receptor substrate binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor substrate binding	ISS Inferred from Sequence or Structural Similarity more info
enables insulin-like growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase activator activity	IEA Inferred from Electronic Annotation more info
enables kinase activator activity	ISO Inferred from Sequence Orthology more info
enables neurotrophin TRKA receptor binding	IEA Inferred from Electronic Annotation more info
enables neurotrophin TRKA receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol 3-kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T follicular helper cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin-like growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-18-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in myeloid leukocyte migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of myeloid leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endoplasmic reticulum unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion disassembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of focal adhesion disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of toll-like receptor 4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fructose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to iron(II) ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to yeast	IEP Inferred from Expression Pattern more info	PubMed
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network	IEA Inferred from Electronic Annotation more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex	TAS Traceable Author Statement more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	IEA Inferred from Electronic Annotation more info
part_of phosphatidylinositol 3-kinase complex, class IA	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class IA	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 3-kinase regulatory subunit alpha

Names: PI3-kinase p85 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase p85 alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide-3-kinase, regulatory subunit 1 (alpha); ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013005.3 → NP_037137.2 phosphatidylinositol 3-kinase regulatory subunit alpha

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

O55085, P70544, Q63787, Q63790

UniProtKB/TrEMBL

A6I5C4, F1LNG5

Conserved Domains (5) summary

cd09930
Location:617 → 720

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:328 → 435

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd11910
Location:5 → 79

SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases

cd12924
Location:440 → 600

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

cd04388
Location:114 → 302

RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

34612946..34697660 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760659.4 → XP_008758881.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

See identical proteins and their annotated locations for XP_008758881.1

UniProtKB/TrEMBL

A6I5C5

Related

ENSRNOP00000067155.2, ENSRNOT00000075057.3

Conserved Domains (4) summary

cd09930
Location:317 → 420

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:28 → 135

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12924
Location:140 → 300

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

pfam16454
Location:139 → 298

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
XM_006231868.5 → XP_006231930.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

See identical proteins and their annotated locations for XP_006231930.1

UniProtKB/TrEMBL

A6I5C6, M0RC47

Related

ENSRNOP00000104471.1, ENSRNOT00000159310.1

Conserved Domains (4) summary

cd09930
Location:347 → 450

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:58 → 165

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12924
Location:170 → 330

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

pfam16454
Location:169 → 328

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain