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    CYP2J2 cytochrome P450 family 2 subfamily J member 2 [ Homo sapiens (human) ]

    Gene ID: 1573, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CYP2J2provided by HGNC
    Official Full Name
    cytochrome P450 family 2 subfamily J member 2provided by HGNC
    Primary source
    HGNC:HGNC:2634
    See related
    Ensembl:ENSG00000134716 MIM:601258; AllianceGenome:HGNC:2634
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPJ2; CYPIIJ2
    Summary
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in small intestine (RPKM 44.5), heart (RPKM 35.2) and 10 other tissues See more
    Orthologs
    all
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    Genomic context

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    See CYP2J2 in Genome Data Viewer
    Location:
    1p32.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (59893308..59969212, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (59771763..59847665, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (60358980..60392445, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378758 Neighboring gene uncharacterized LOC101926944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 943 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:60280925-60281488 Neighboring gene hook microtubule tethering protein 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:60380537-60381736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:60391793-60392328 Neighboring gene RNA, 7SL, cytoplasmic 475, pseudogene Neighboring gene chromosome 1 open reading frame 87 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:60505410-60506609

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy. Westphal C, et al. PLoS One, 2013. PMID 24023684, Free PMC Article
    2. Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity. Lee SS, et al. Pharmacogenet Genomics, 2005 Feb. PMID 15861034
    3. Cytochrome P450 2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth. Chen C, et al. J Pharmacol Exp Ther, 2011 Feb. PMID 21030485, Free PMC Article
    4. Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. Spiecker M, et al. Circulation, 2004 Oct 12. PMID 15466638, Free PMC Article
    5. Enhancement of cardiac L-type Ca2+ currents in transgenic mice with cardiac-specific overexpression of CYP2J2. Xiao YF, et al. Mol Pharmacol, 2004 Dec. PMID 15361551

    See all (136) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.
      Title: CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.
    2. Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.
      Title: Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.
    3. CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.
      Title: CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.
    4. CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
      Title: CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
    5. 6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2.
      Title: 6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2.
    6. Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.
      Title: Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.
    7. Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.
      Title: Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.
    8. CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes.
      Title: CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes.
    9. In conclusion, the rs2280275 and rs11572325 SNPs of CYP2J2 may be considered novel genetic markers of hypertension, at least in Russian women
      Title: A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk.
    10. CYP2J2 50G>T (rs890293) polymorphism was associated with an increased risk for psoriasis in the Turkish population
      Title: Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study.
    Submit: New GeneRIF Correction See all GeneRIFs (106)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables arachidonate 11,12-epoxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arachidonate 14,15-epoxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arachidonate 5,6-epoxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate epoxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arachidonate epoxygenase activity TAS
    Traceable Author Statement
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroperoxy icosatetraenoate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables linoleic acid epoxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monooxygenase activity TAS
    Traceable Author Statement
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epoxygenase P450 pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in icosanoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in linoleic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heart contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 2J2
    Names
    albendazole monooxygenase (hydroxylating)
    albendazole monooxygenase (sulfoxide-forming)
    arachidonic acid epoxygenase
    cytochrome P450, family 2, subfamily J, polypeptide 2
    cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2
    flavoprotein-linked monooxygenase
    hydroperoxy icosatetraenoate isomerase
    microsomal monooxygenase
    NP_000766.2
    XP_047303454.1
    XP_047303455.1
    XP_054190678.1
    XP_054190679.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007931.2 RefSeqGene

      Range
      47439..80904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000775.4 → NP_000766.2  cytochrome P450 2J2

      See identical proteins and their annotated locations for NP_000766.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the protein-coding transcript.
      Source sequence(s)
      BC032594
      Consensus CDS
      CCDS613.1
      UniProtKB/Swiss-Prot
      B2RD33, P51589, Q8TF13
      Related
      ENSP00000360247.3, ENST00000371204.4
      Conserved Domains (1) summary
      pfam00067
      Location:44 → 497
      p450; Cytochrome P450

    RNA

    1. NR_134981.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC032594, CD013972
      Related
      ENST00000466095.5

    2. NR_134982.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC113175, BC032594, CD013973
      Related
      ENST00000468257.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      59893308..59969212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447499.1 → XP_047303455.1  cytochrome P450 2J2 isoform X1

    2. XM_047447498.1 → XP_047303454.1  cytochrome P450 2J2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      59771763..59847665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334704.1 → XP_054190679.1  cytochrome P450 2J2 isoform X1

    2. XM_054334703.1 → XP_054190678.1  cytochrome P450 2J2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51589.2 GenPept UniProtKB/Swiss-Prot:P51589

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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