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    DHX32 DEAH-box helicase 32 (putative) [ Homo sapiens (human) ]

    Gene ID: 55760, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DHX32provided by HGNC
    Official Full Name
    DEAH-box helicase 32 (putative)provided by HGNC
    Primary source
    HGNC:HGNC:16717
    See related
    Ensembl:ENSG00000089876 MIM:607960; AllianceGenome:HGNC:16717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DDX32; DHLP1
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 18.2), colon (RPKM 13.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DHX32 in Genome Data Viewer
    Location:
    10q26.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (125836337..125896485, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (126718811..126779414, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (127524906..127569861, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2924 Neighboring gene matrix metallopeptidase 21 Neighboring gene uroporphyrinogen III synthase Neighboring gene CRISPRi-validated UROS cis-regulatory element Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:127511755-127512440 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:127512660-127512879 Neighboring gene microRNA 4484 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene ReSE screen-validated silencer GRCh37_chr10:127541940-127542119 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:127569451-127570173 Neighboring gene Sharpr-MPRA regulatory region 1957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2928 Neighboring gene Sharpr-MPRA regulatory region 15703 Neighboring gene RNA, U2 small nuclear 42, pseudogene Neighboring gene fibronectin type III and ankyrin repeat domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127623020-127623520 Neighboring gene G protein subunit gamma 10 pseudogene 1 Neighboring gene FANK1 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells. Alli Z, et al. Cell Immunol, 2005 Oct. PMID 16414036
    2. Nuclear and mitochondrial localization of the putative RNA helicase DHX32. Alli Z, et al. Exp Mol Pathol, 2006 Dec. PMID 16959245
    3. A role for DHX32 in regulating T-cell apoptosis. Alli Z, et al. Anticancer Res, 2007 Jan-Feb. PMID 17352256
    4. Up-regulation and clinical relevance of novel helicase homologue DHX32 in colorectal cancer. Huang C, et al. J Exp Clin Cancer Res, 2009 Jan 22. PMID 19161603, Free PMC Article
    5. Structure and function of DEAH-box helicase 32 and its role in cancer. Wei Q, et al. Oncol Lett, 2021 May. PMID 33777205, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DEAH-box polypeptide 32 promotes hepatocellular carcinoma progression via activating the beta-catenin pathway.
      Title: DEAH-box polypeptide 32 promotes hepatocellular carcinoma progression via activating the β-catenin pathway.
    2. Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer.
      Title: Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer.
    3. DHX32 is an upstream regulator for beta-catenin, which promotes the activity of beta-catenin to upregulate expression of VEGFA in colorectal cancer cells. Depletion of DHX32 expression suppressed colorectal cancer tumor angiogenesis and tumor growth.
      Title: DHX32 Promotes Angiogenesis in Colorectal Cancer Through Augmenting β-catenin Signaling to Induce Expression of VEGFA.
    4. DHX32 may play an important role in the development of colorectal cancer and could serve as a novel biomarker for colorectal cancer after additional investigation.
      Title: Up-regulation and clinical relevance of novel helicase homologue DHX32 in colorectal cancer.
    5. In peripheral blood lymphocytes, a correlation between DHX32 and c-FLIP short expression was detected in response to different T-cell activation stimuli. Results suggest DHX32 involvement in regulating T-cell response to apoptotic stimuli.
      Title: A role for DHX32 in regulating T-cell apoptosis.
    6. Structural characterization and expression of the DDX32 gene. Expression studies show that DDX32 is widespread but specifically down-regulated in acute lymphoblastic leukemias and might play a role in normal and/or abnormal lymphopoiesis.
      Title: The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia.
    7. cloned DHX32 proximal promoter and identified a 218bp fragment containing two potential binding sites for the transcription factor nuclear factor of activated T cells (NF-AT)
      Title: The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells.
    8. dysregulated expression of DHX32 might lead to as of yet unknown changes in mitochondrial homeostasis manifested by cytoplasmic redistribution of the molecular chaperon Hsp60
      Title: Altered distribution of heat shock protein 60 (Hsp60) with dysregulated expression of DHX32.
    9. These results suggest that DHX32 is a putative RNA helicase that might be involved in regulating nuclear and mitochondrial gene expression.
      Title: Nuclear and mitochondrial localization of the putative RNA helicase DHX32.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10694, FLJ10889

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HTP PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32
    DEAD/H box 32
    DEAD/H helicase-like protein-1
    DEAH (Asp-Glu-Ala-His) box polypeptide 32
    DEAH box protein 32
    huDDX32
    NP_060650.2
    XP_047281423.1
    XP_047281424.1
    XP_047281425.1
    XP_047281426.1
    XP_054222253.1
    XP_054222254.1
    XP_054222255.1
    XP_054222256.1
    XP_054222257.1
    XP_054222258.1
    XP_054222259.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018180.3 → NP_060650.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

      See identical proteins and their annotated locations for NP_060650.2

      Status: REVIEWED

      Source sequence(s)
      AL360176
      Consensus CDS
      CCDS7652.1
      UniProtKB/Swiss-Prot
      A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7
      UniProtKB/TrEMBL
      B2RD71
      Related
      ENSP00000284690.3, ENST00000284690.4
      Conserved Domains (1) summary
      COG1643
      Location:12 → 679
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      125836337..125896485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425470.1 → XP_047281426.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

      UniProtKB/Swiss-Prot
      A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7
      UniProtKB/TrEMBL
      B2RD71

    2. XM_047425468.1 → XP_047281424.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

      UniProtKB/TrEMBL
      B2RD71

    3. XM_047425469.1 → XP_047281425.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

      UniProtKB/Swiss-Prot
      A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7
      UniProtKB/TrEMBL
      B2RD71

    4. XM_047425467.1 → XP_047281423.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

      UniProtKB/TrEMBL
      B2RD71

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      126718811..126779414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366280.1 → XP_054222255.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

      UniProtKB/Swiss-Prot
      A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7
      UniProtKB/TrEMBL
      B2RD71

    2. XM_054366281.1 → XP_054222256.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

      UniProtKB/Swiss-Prot
      A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7
      UniProtKB/TrEMBL
      B2RD71

    3. XM_054366278.1 → XP_054222253.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

      UniProtKB/TrEMBL
      B2RD71

    4. XM_054366279.1 → XP_054222254.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

      UniProtKB/TrEMBL
      B2RD71

    5. XM_054366283.1 → XP_054222258.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

      UniProtKB/Swiss-Prot
      A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7
      UniProtKB/TrEMBL
      B2RD71

    6. XM_054366282.1 → XP_054222257.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

      UniProtKB/Swiss-Prot
      A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7
      UniProtKB/TrEMBL
      B2RD71

    7. XM_054366284.1 → XP_054222259.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

      UniProtKB/Swiss-Prot
      A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7
      UniProtKB/TrEMBL
      B2RD71
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L7V1.1 GenPept UniProtKB/Swiss-Prot:Q7L7V1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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