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    Pfdn6 prefoldin subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 14976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pfdn6provided by MGI
    Official Full Name
    prefoldin subunit 6provided by MGI
    Primary source
    MGI:MGI:95908
    See related
    Ensembl:ENSMUSG00000024309 AllianceGenome:MGI:95908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ke-2; H-2Ke2; H2-Ke2
    Summary
    Predicted to enable amyloid-beta binding activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone-mediated protein complex assembly; negative regulation of amyloid fibril formation; and protein folding. Predicted to be part of RPAP3/R2TP/prefoldin-like complex and prefoldin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human PFDN6 (prefoldin subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 40.0), liver E14 (RPKM 35.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pfdn6 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34157883..34159317, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33938909..33940343, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5592 Neighboring gene STARR-positive B cell enhancer ABC_E7521 Neighboring gene predicted gene, 19412 Neighboring gene TAP binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34066718-34066827 Neighboring gene ral guanine nucleotide dissociation stimulator-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E1938 Neighboring gene WD repeat domain 46 Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A putative transmembrane protein with histidine-rich charge clusters encoded in the H-2K/tw5 region of mice. St-Jacques B, et al. Mol Cell Biol, 1990 Jan. PMID 2294398, Free PMC Article
    2. Searching for coding sequences in the mammalian genome: the H-2K region of the mouse MHC is replete with genes expressed in embryos. Abe K, et al. EMBO J, 1988 Nov. PMID 2463160, Free PMC Article
    3. The molecular organization of the H-2K region of two t-haplotypes: implications for the evolution of genetic diversity. Uehara H, et al. EMBO J, 1987 Jan. PMID 3034582, Free PMC Article
    4. Sequence, linkage to H2-K, and function of mouse tapasin in MHC class I assembly. Grandea AG 3rd, et al. Immunogenetics, 1998 Sep. PMID 9716645
    5. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Dai N, et al. Cell Metab, 2015 Apr 7. PMID 25863250, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone-mediated protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of amyloid fibril formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RPAP3/R2TP/prefoldin-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of prefoldin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prefoldin subunit 6
    Names
    H2-K region expressed gene 2
    protein Ke2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185182.1 → NP_001172111.1  prefoldin subunit 6

      See identical proteins and their annotated locations for NP_001172111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA023721, AV446044, CR974462
      Consensus CDS
      CCDS28636.1
      UniProtKB/Swiss-Prot
      Q03958
      UniProtKB/TrEMBL
      Q792E4
      Related
      ENSMUSP00000137072.2, ENSMUST00000179418.9
      Conserved Domains (1) summary
      cd00632
      Location:9 → 113
      Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...

    2. NM_010385.2 → NP_034515.1  prefoldin subunit 6

      See identical proteins and their annotated locations for NP_034515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK010679, AV446044, BY238879
      Consensus CDS
      CCDS28636.1
      UniProtKB/Swiss-Prot
      Q03958
      UniProtKB/TrEMBL
      Q792E4
      Related
      ENSMUSP00000025163.8, ENSMUST00000025163.14
      Conserved Domains (1) summary
      cd00632
      Location:9 → 113
      Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34157883..34159317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03958.1 GenPept UniProtKB/Swiss-Prot:Q03958

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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