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    Cenpm centromere protein M [ Mus musculus (house mouse) ]

    Gene ID: 66570, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cenpmprovided by MGI
    Official Full Name
    centromere protein Mprovided by MGI
    Primary source
    MGI:MGI:1913820
    See related
    Ensembl:ENSMUSG00000068101 AllianceGenome:MGI:1913820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pane1; 2610019I03Rik
    Summary
    This gene encodes a protein that is present in the nucleus of actively growing cells but is excluded from the nucleus during cell division or during growth arrest as a result of contact inhibition. In human, this protein is a component of the CENP-A nucleosome-associated complex that regulates kinetochore protein assembly, mitotic cell-cycle progression, and chromosome segregation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.4), thymus adult (RPKM 7.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cenpm in Genome Data Viewer
    Location:
    15 E1; 15 38.56 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82115694..82128974, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82233762..82244773, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene shisa family member 8 Neighboring gene STARR-positive B cell enhancer ABC_E2448 Neighboring gene tumor necrosis factor receptor superfamily, member 13c Neighboring gene STARR-positive B cell enhancer ABC_E8601 Neighboring gene STARR-seq mESC enhancer starr_39290 Neighboring gene small integral membrane protein 45 Neighboring gene predicted gene, 52180 Neighboring gene septin 3 Neighboring gene STARR-seq mESC enhancer starr_39292

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin. Renou JP, et al. Oncogene, 2003 Jul 17. PMID 12881717
    2. The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells. Bierie B, et al. Gene Expr Patterns, 2004 Jul. PMID 15183305
    3. Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Hentges KE, et al. Genomics, 2002 Aug. PMID 12160734
    4. Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Kumada T, et al. Dev Dyn, 2010 Aug. PMID 20568244
    5. Structural insights into human CCAN complex assembled onto DNA. Tian T, et al. Cell Discov, 2022 Sep 9. PMID 36085283, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A new 20 kDa protein (PANE1) induced upon transdifferentiation was nuclear in nonconfluent cells and cytoplasmic in confluent or dividing cells.
      Title: Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein M
    Names
    CENP-M
    proliferation associated nuclear element 1
    proliferation-associated nuclear element protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080158.1 → NP_001073627.1  centromere protein M isoform 3

      See identical proteins and their annotated locations for NP_001073627.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI853711, AK011227, BG276334
      UniProtKB/Swiss-Prot
      Q9CQA0
      Conserved Domains (1) summary
      pfam11111
      Location:1 → 137
      CENP-M; Centromere protein M (CENP-M)

    2. NM_025639.4 → NP_079915.1  centromere protein M isoform 1

      See identical proteins and their annotated locations for NP_079915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI853711, AK011227, BY710734
      Consensus CDS
      CCDS27685.1
      UniProtKB/Swiss-Prot
      Q3THN3, Q91VS6, Q9CQA0
      Related
      ENSMUSP00000086560.4, ENSMUST00000089157.11
      Conserved Domains (1) summary
      pfam11111
      Location:1 → 172
      CENP-M; Centromere protein M (CENP-M)

    3. NM_178269.3 → NP_840000.2  centromere protein M isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI853711, AK011227, BY710734
      Consensus CDS
      CCDS37156.1
      UniProtKB/Swiss-Prot
      Q9CQA0
      Related
      ENSMUSP00000086558.5, ENSMUST00000089155.6
      Conserved Domains (1) summary
      pfam11111
      Location:1 → 110
      CENP-M; Centromere protein M (CENP-M)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82115694..82128974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248697.2 → XP_030104557.1  centromere protein M isoform X4

      Conserved Domains (1) summary
      pfam11111
      Location:1 → 78
      CENP-M; Centromere protein M (CENP-M)

    2. XM_036159540.1 → XP_036015433.1  centromere protein M isoform X5

      Conserved Domains (1) summary
      pfam11111
      Location:1 → 75
      CENP-M; Centromere protein M (CENP-M)

    3. XM_017316722.2 → XP_017172211.1  centromere protein M isoform X2

      Conserved Domains (1) summary
      pfam11111
      Location:1 → 140
      CENP-M; Centromere protein M (CENP-M)

    4. XM_006521260.5 → XP_006521323.1  centromere protein M isoform X3

      See identical proteins and their annotated locations for XP_006521323.1

      Conserved Domains (1) summary
      pfam11111
      Location:1 → 137
      CENP-M; Centromere protein M (CENP-M)

    5. XM_036159541.1 → XP_036015434.1  centromere protein M isoform X6

      Conserved Domains (1) summary
      pfam11111
      Location:13 → 106
      CENP-M; Centromere protein M (CENP-M)

    6. XM_011245710.4 → XP_011244012.1  centromere protein M isoform X1

      Conserved Domains (1) summary
      pfam11111
      Location:1 → 134
      CENP-M; Centromere protein M (CENP-M)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQA0.1 GenPept UniProtKB/Swiss-Prot:Q9CQA0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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