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    Sorcs2 sortilin-related VPS10 domain containing receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 81840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sorcs2provided by MGI
    Official Full Name
    sortilin-related VPS10 domain containing receptor 2provided by MGI
    Primary source
    MGI:MGI:1932289
    See related
    Ensembl:ENSMUSG00000029093 AllianceGenome:MGI:1932289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1329
    Summary
    Involved in intracellular protein transport and long-term synaptic depression. Located in endosome membrane; plasma membrane; and postsynaptic density. Is expressed in several structures, including brain; future spinal cord; musculature; sensory organ; and spinal cord. Orthologous to human SORCS2 (sortilin related VPS10 domain containing receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 13.6), limb E14.5 (RPKM 13.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sorcs2 in Genome Data Viewer
    Location:
    5 B3; 5 19.14 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (36174524..36555541, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36017180..36398197, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8820 Neighboring gene actin-binding LIM protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E8050 Neighboring gene H2A histone family, pseudogene 1 Neighboring gene actin filament associated protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36316611-36316857 Neighboring gene STARR-positive B cell enhancer mm9_chr5:36376513-36376814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36431991-36432296 Neighboring gene predicted gene, 52811 Neighboring gene STARR-positive B cell enhancer mm9_chr5:36487276-36487576 Neighboring gene predicted gene, 52810 Neighboring gene STARR-seq mESC enhancer starr_12872 Neighboring gene predicted gene, 32183 Neighboring gene predicted gene, 31945 Neighboring gene predicted gene, 32119 Neighboring gene prosaposin-like 1 Neighboring gene microRNA 7689 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36701008-36701161 Neighboring gene STARR-positive B cell enhancer mm9_chr5:36715900-36716201 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36720744-36720945 Neighboring gene RIKEN cDNA 2210406O10 gene Neighboring gene STARR-positive B cell enhancer ABC_E65 Neighboring gene GrpE-like 1, mitochondrial Neighboring gene transcriptional adaptor 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells. Kalnytska O, et al. iScience, 2024 Jan 19. PMID 38226160, Free PMC Article
    2. Reduced Alcohol Seeking and Withdrawal Symptoms in Mice Lacking the BDNF Receptor SorCS2. Olsen D, et al. Front Pharmacol, 2019. PMID 31156431, Free PMC Article
    3. SorCS2 facilitates release of endostatin from astrocytes and controls post-stroke angiogenesis. Malik AR, et al. Glia, 2020 Jun. PMID 31898841
    4. SorCS2 is required for social memory and trafficking of the NMDA receptor. Yang J, et al. Mol Psychiatry, 2021 Mar. PMID 31988435
    5. Hippocampal SorCS2 overexpression represses chronic stress-induced depressive-like behaviors by promoting the BDNF-TrkB system. Chen WJ, et al. Pharmacol Biochem Behav, 2024 Sep. PMID 38996926

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hippocampal SorCS2 overexpression represses chronic stress-induced depressive-like behaviors by promoting the BDNF-TrkB system.
      Title: Hippocampal SorCS2 overexpression represses chronic stress-induced depressive-like behaviors by promoting the BDNF-TrkB system.
    2. SorCS2 binds progranulin to regulate motor neuron development.
      Title: SorCS2 binds progranulin to regulate motor neuron development.
    3. Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.
      Title: Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.
    4. SorCS2 is required for social memory and trafficking of the NMDA receptor.
      Title: SorCS2 is required for social memory and trafficking of the NMDA receptor.
    5. THe sortilin and SorCS2 are extensively present in several distinct anatomical areas in the developing nervous system and are rarely co-expressed.
      Title: Highly segregated localization of the functionally related vps10p receptors sortilin and SorCS2 during neurodevelopment.
    6. structural analysis of binding of NGF, proNGF, and proBDNF to SorCS2
      Title: Structural insights into SorCS2-Nerve Growth Factor complex formation.
    7. Results indicate that hearing loss and hair bundle defects are associated with SorCS2 (Sortilin-related VPS-10 domain containing protein) disruption.
      Title: Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear.
    8. SorCS2 is expressed in mesodermally derived tissues such as striated muscle, adipose tissue, ossifying bone and connective tissue.
      Title: Spatiotemporal patterns of sortilin and SorCS2 localization during organ development.
    9. SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis
      Title: The three sorCS genes are differentially expressed and regulated by synaptic activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    VPS10 domain-containing receptor SorCS2
    Names
    VPS10 domain receptor protein SORCS 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030889.2 → NP_112151.2  VPS10 domain-containing receptor SorCS2 precursor

      See identical proteins and their annotated locations for NP_112151.2

      Status: VALIDATED

      Source sequence(s)
      AC127275, AK047881, AK053853, AY004316, CO428928, CV784176
      Consensus CDS
      CCDS19237.1
      UniProtKB/Swiss-Prot
      B2RSI2, B2RSI4, Q9EPR5
      UniProtKB/TrEMBL
      Q8CHA4
      Related
      ENSMUSP00000041828.8, ENSMUST00000037370.14
      Conserved Domains (3) summary
      smart00602
      Location:170 → 776
      VPS10; VPS10 domain
      PHA03307
      Location:1 → 130
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00801
      Location:798 → 860
      PKD; PKD domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      36174524..36555541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504202.4 → XP_006504265.1  VPS10 domain-containing receptor SorCS2 isoform X1

      UniProtKB/TrEMBL
      Q8CHA4
      Conserved Domains (3) summary
      smart00602
      Location:170 → 776
      VPS10; VPS10 domain
      PHA03307
      Location:1 → 130
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00801
      Location:798 → 860
      PKD; PKD domain

    2. XM_036165631.1 → XP_036021524.1  VPS10 domain-containing receptor SorCS2 isoform X3

      UniProtKB/TrEMBL
      Q8CHA4
      Conserved Domains (2) summary
      smart00602
      Location:30 → 636
      VPS10; VPS10 domain
      pfam00801
      Location:658 → 723
      PKD; PKD domain

    3. XM_036165630.1 → XP_036021523.1  VPS10 domain-containing receptor SorCS2 isoform X2

      UniProtKB/TrEMBL
      Q8CHA4
      Conserved Domains (2) summary
      smart00602
      Location:30 → 636
      VPS10; VPS10 domain
      pfam00801
      Location:658 → 723
      PKD; PKD domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPR5.2 GenPept UniProtKB/Swiss-Prot:Q9EPR5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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