U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    SPAG16 sperm associated antigen 16 [ Homo sapiens (human) ]

    Gene ID: 79582, updated on 10-Dec-2024

    Summary

    Official Symbol
    SPAG16provided by HGNC
    Official Full Name
    sperm associated antigen 16provided by HGNC
    Primary source
    HGNC:HGNC:23225
    See related
    Ensembl:ENSG00000144451 MIM:612173; AllianceGenome:HGNC:23225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PF20; WDR29
    Summary
    Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008]
    Expression
    Broad expression in testis (RPKM 2.7), thyroid (RPKM 1.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SPAG16 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (213284464..214410501)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (213765296..214894995)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (214149188..215275225)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985981 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:214053177-214054037 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:214052314-214053176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:214054900-214055760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17066 Neighboring gene SPAG16 divergent transcript Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:214276253-214277452 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:214552640-214553482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17069 Neighboring gene microRNA 4438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:214898800-214899778 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:214899779-214900755 Neighboring gene uncharacterized LOC101928084 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:214991690-214992362 Neighboring gene uncharacterized LOC124907973 Neighboring gene ribosomal protein L5 pseudogene 8 Neighboring gene von Willebrand factor C domain containing 2 like Neighboring gene VWC2L intronic transcript 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:215458325-215458965 Neighboring gene endosulfine alpha pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (10 hits/1264 screens)

    EBI GWAS Catalog

    Description
    Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of sperm associated antigen 16 (SPAG16) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • FLJ22724, FLJ37717, MGC87036, DKFZp666P1710

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in axoneme assembly  
    involved_in axoneme assembly PubMed 
    involved_in cerebrospinal fluid circulation  
    involved_in cilium assembly  
    involved_in mucociliary clearance  
    involved_in sperm axoneme assembly  
    Component Evidence Code Pubs
    is_active_in axonemal central apparatus  
    located_in axoneme  
    located_in extracellular region  
    located_in sperm flagellum  

    General protein information

    Preferred Names
    sperm-associated antigen 16 protein
    Names
    WD repeat domain 29
    pf20 protein homolog
    sperm-associated WD repeat protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025436.3NP_001020607.1  sperm-associated antigen 16 protein isoform 2

      See identical proteins and their annotated locations for NP_001020607.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and lacks a large portion of the 3' coding region, compared to variant 1. The encoded isoform (2) is significantly shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC067756, CA313710
      Consensus CDS
      CCDS46508.1
      UniProtKB/Swiss-Prot
      Q8N0X2
      UniProtKB/TrEMBL
      Q4G1A2
      Related
      ENSP00000415079.2, ENST00000432529.6
    2. NM_024532.5NP_078808.3  sperm-associated antigen 16 protein isoform 1

      See identical proteins and their annotated locations for NP_078808.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF310672, AF490390, AK302351
      Consensus CDS
      CCDS2396.1
      UniProtKB/Swiss-Prot
      Q498B7, Q658W1, Q68DB3, Q6I9Z6, Q8N0X2, Q8N9C7, Q9H601
      UniProtKB/TrEMBL
      Q4G1A2
      Related
      ENSP00000332592.5, ENST00000331683.10
      Conserved Domains (4) summary
      COG2319
      Location:341631
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:344631
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:355392
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:160271
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RNA

    1. NR_047659.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK302351, AW207406, BC025379
      Related
      ENST00000406979.6
    2. NR_047660.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK302351, BC025379

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      213284464..214410501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511814.2XP_011510116.1  sperm-associated antigen 16 protein isoform X1

      UniProtKB/TrEMBL
      Q4G1A2
      Conserved Domains (4) summary
      COG2319
      Location:310600
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:313600
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:324361
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:129240
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    2. XM_011511820.3XP_011510122.1  sperm-associated antigen 16 protein isoform X7

      Conserved Domains (4) summary
      COG2319
      Location:302569
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:344569
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:355392
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:160271
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    3. XM_011511815.3XP_011510117.1  sperm-associated antigen 16 protein isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:342577
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:348580
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:356392
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:160271
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    4. XM_011511817.3XP_011510119.1  sperm-associated antigen 16 protein isoform X4

      Conserved Domains (3) summary
      COG2319
      Location:341561
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:348551
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:356392
      7WD40; WD40 repeat [structural motif]
    5. XM_011511816.4XP_011510118.1  sperm-associated antigen 16 protein isoform X3

      Conserved Domains (4) summary
      COG2319
      Location:343585
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:348551
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:356392
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:160271
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    6. XM_011511818.3XP_011510120.1  sperm-associated antigen 16 protein isoform X6

      Conserved Domains (4) summary
      COG2319
      Location:341561
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:348551
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:356392
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:160271
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    7. XM_011511824.3XP_011510126.1  sperm-associated antigen 16 protein isoform X9

      Conserved Domains (3) summary
      COG2319
      Location:341516
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:348518
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:356392
      7WD40; WD40 repeat [structural motif]
    8. XM_011511831.3XP_011510133.1  sperm-associated antigen 16 protein isoform X15

      See identical proteins and their annotated locations for XP_011510133.1

      UniProtKB/TrEMBL
      E7EWV3
    9. XM_011511832.3XP_011510134.1  sperm-associated antigen 16 protein isoform X16

      See identical proteins and their annotated locations for XP_011510134.1

      UniProtKB/TrEMBL
      E7EWV3
    10. XM_011511828.3XP_011510130.1  sperm-associated antigen 16 protein isoform X13

      UniProtKB/TrEMBL
      E7EWV3
    11. XM_011511829.3XP_011510131.1  sperm-associated antigen 16 protein isoform X14

      UniProtKB/TrEMBL
      E7EWV3
    12. XM_011511827.3XP_011510129.1  sperm-associated antigen 16 protein isoform X12

      UniProtKB/TrEMBL
      E7EWV3
    13. XM_011511837.4XP_011510139.1  sperm-associated antigen 16 protein isoform X20

      UniProtKB/TrEMBL
      E7EWV3
    14. XM_006712746.4XP_006712809.1  sperm-associated antigen 16 protein isoform X18

      UniProtKB/TrEMBL
      E7EWV3
      Related
      ENSP00000400847.1, ENST00000447990.1
    15. XM_017004899.3XP_016860388.1  sperm-associated antigen 16 protein isoform X17

    16. XM_011511823.4XP_011510125.1  sperm-associated antigen 16 protein isoform X8

      See identical proteins and their annotated locations for XP_011510125.1

      UniProtKB/TrEMBL
      B4DYB5, C9JV44
      Conserved Domains (2) summary
      cd00200
      Location:241528
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:252289
      7WD40; WD40 repeat [structural motif]
    17. XM_011511819.3XP_011510121.1  sperm-associated antigen 16 protein isoform X5

      UniProtKB/TrEMBL
      Q4G1A2
      Conserved Domains (4) summary
      COG2319
      Location:287577
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:290577
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:301338
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:106217
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    18. XM_047445817.1XP_047301773.1  sperm-associated antigen 16 protein isoform X10

      UniProtKB/TrEMBL
      B4DYB5, C9JV44
    19. XM_017004897.1XP_016860386.1  sperm-associated antigen 16 protein isoform X10

      UniProtKB/TrEMBL
      B4DYB5, C9JV44
      Conserved Domains (4) summary
      COG2319
      Location:222512
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:225512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:236273
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:41152
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    20. XM_017004898.1XP_016860387.1  sperm-associated antigen 16 protein isoform X11

    21. XM_024453140.2XP_024308908.1  sperm-associated antigen 16 protein isoform X19

      Conserved Domains (2) summary
      cd00200
      Location:38325
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4986
      7WD40; WD40 repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      213765296..214894995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343872.1XP_054199847.1  sperm-associated antigen 16 protein isoform X1

      UniProtKB/TrEMBL
      Q4G1A2
    2. XM_054343878.1XP_054199853.1  sperm-associated antigen 16 protein isoform X7

    3. XM_054343873.1XP_054199848.1  sperm-associated antigen 16 protein isoform X2

    4. XM_054343875.1XP_054199850.1  sperm-associated antigen 16 protein isoform X4

    5. XM_054343874.1XP_054199849.1  sperm-associated antigen 16 protein isoform X3

    6. XM_054343877.1XP_054199852.1  sperm-associated antigen 16 protein isoform X6

    7. XM_054343880.1XP_054199855.1  sperm-associated antigen 16 protein isoform X9

    8. XM_054343882.1XP_054199857.1  sperm-associated antigen 16 protein isoform X21

    9. XM_054343887.1XP_054199862.1  sperm-associated antigen 16 protein isoform X15

      UniProtKB/TrEMBL
      E7EWV3
    10. XM_054343888.1XP_054199863.1  sperm-associated antigen 16 protein isoform X16

      UniProtKB/TrEMBL
      E7EWV3
    11. XM_054343885.1XP_054199860.1  sperm-associated antigen 16 protein isoform X13

      UniProtKB/TrEMBL
      E7EWV3
    12. XM_054343886.1XP_054199861.1  sperm-associated antigen 16 protein isoform X14

      UniProtKB/TrEMBL
      E7EWV3
    13. XM_054343884.1XP_054199859.1  sperm-associated antigen 16 protein isoform X12

      UniProtKB/TrEMBL
      E7EWV3
    14. XM_054343892.1XP_054199867.1  sperm-associated antigen 16 protein isoform X20

      UniProtKB/TrEMBL
      E7EWV3
    15. XM_054343890.1XP_054199865.1  sperm-associated antigen 16 protein isoform X18

      UniProtKB/TrEMBL
      E7EWV3
    16. XM_054343889.1XP_054199864.1  sperm-associated antigen 16 protein isoform X17

    17. XM_054343879.1XP_054199854.1  sperm-associated antigen 16 protein isoform X8

      UniProtKB/TrEMBL
      B4DYB5, C9JV44
    18. XM_054343876.1XP_054199851.1  sperm-associated antigen 16 protein isoform X5

      UniProtKB/TrEMBL
      Q4G1A2
    19. XM_054343881.1XP_054199856.1  sperm-associated antigen 16 protein isoform X10

      UniProtKB/TrEMBL
      B4DYB5, C9JV44
    20. XM_054343883.1XP_054199858.1  sperm-associated antigen 16 protein isoform X11

    21. XM_054343891.1XP_054199866.1  sperm-associated antigen 16 protein isoform X19

    External link. Please review our privacy policy.