Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spsb1provided by MGI
Official Full Name: splA/ryanodine receptor domain and SOCS box containing 1provided by MGI
Primary source: MGI:MGI:1921896
See related: Ensembl:ENSMUSG00000039911 AllianceGenome:MGI:1921896
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SSB1; SSB-1; 1110014L01Rik; 4930422J18Rik
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytosol. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in ovary adult (RPKM 81.3), testis adult (RPKM 13.6) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 80.46 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (149980740..150039494, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (149896283..149955006, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPSB1-mediated inhibition of TGF-beta receptor-II impairs myogenesis in inflammation.
Title: SPSB1-mediated inhibition of TGF-β receptor-II impairs myogenesis in inflammation.
these results establish SSB1/2 as safeguards of B cell development and unveil their differential requirement in immature and mature B lymphocytes
Title: SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors.
Collectively, Ssb1 and Ssb2 control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability.
Title: Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.
SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.
Title: SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor.
Findings define a novel pathway that contributes to breast cancer recurrence and provide evidence implicating SPSB proteins in cancer.
Title: SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling.
Collectively, these results demonstrate essential roles of Ssb1 in embryogenesis, spermatogenesis, and genome stability in vivo.
Title: Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.
These results suggest that SPSB1 acts through a negative-feedback loop that, together with SPSB2, controls the extent of iNOS induction and nitric oxide production.
Title: TLR regulation of SPSB1 controls inducible nitric oxide synthase induction.
SPSB1 and SPSB4 bind strongly to both Par-4 and VASA peptides.
Title: Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
Spsb1 is responsive to stress caused by ethanol exposure in the mouse brain, which suggests that Spsb genes have acquired different regulatory mechanisms.
Title: Divergence of the vertebrate sp1A/ryanodine receptor domain and SOCS box-containing (Spsb) gene family and its expression and regulation within the mouse brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

General gene information

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Markers

D4Mit127 (e-PCR), detects polymorphism
- UniSTS:129901

D4Nds5 (e-PCR), detects polymorphism
- UniSTS:142477

AI596360 (e-PCR)
- UniSTS:179106

AI854583 (e-PCR)
- UniSTS:165371

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: SPRY domain-containing SOCS box protein 1

Names: SPRY domain-containing SOCS box protein SSB-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419256.1 → NP_001406185.1 SPRY domain-containing SOCS box protein 1

Status: VALIDATED

Source sequence(s)

AL606914

UniProtKB/Swiss-Prot

Q5FWI0, Q8BJA4, Q9D5L7
NM_001419257.1 → NP_001406186.1 SPRY domain-containing SOCS box protein 1

Status: VALIDATED

Source sequence(s)

AL606914

UniProtKB/Swiss-Prot

Q5FWI0, Q8BJA4, Q9D5L7
NM_001419258.1 → NP_001406187.1 SPRY domain-containing SOCS box protein 1

Status: VALIDATED

Source sequence(s)

AL606914

UniProtKB/Swiss-Prot

Q5FWI0, Q8BJA4, Q9D5L7

Related

ENSMUSP00000101309.2, ENSMUST00000105684.2
NM_001419259.1 → NP_001406188.1 SPRY domain-containing SOCS box protein 1

Status: VALIDATED

Source sequence(s)

AL606914

UniProtKB/Swiss-Prot

Q5FWI0, Q8BJA4, Q9D5L7
NM_029035.3 → NP_083311.1 SPRY domain-containing SOCS box protein 1

See identical proteins and their annotated locations for NP_083311.1

Status: VALIDATED

Source sequence(s)

AL606914

Consensus CDS

CCDS18966.1

UniProtKB/Swiss-Prot

Q5FWI0, Q8BJA4, Q9D5L7

Related

ENSMUSP00000048969.3, ENSMUST00000038562.9

Conserved Domains (2) summary

cd12906
Location:54 → 227

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

cl02533
Location:232 → 273

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

149980740..150039494 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539234.4 → XP_006539297.1 SPRY domain-containing SOCS box protein 1 isoform X1

See identical proteins and their annotated locations for XP_006539297.1

UniProtKB/Swiss-Prot

Q5FWI0, Q8BJA4, Q9D5L7

Related

ENSMUSP00000101310.2, ENSMUST00000105685.2

Conserved Domains (2) summary

cd12906
Location:54 → 227

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

cl02533
Location:232 → 273

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...