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    Axin2 axin 2 [ Mus musculus (house mouse) ]

    Gene ID: 12006, updated on 3-Dec-2024

    Summary

    Official Symbol
    Axin2provided by MGI
    Official Full Name
    axin 2provided by MGI
    Primary source
    MGI:MGI:1270862
    See related
    Ensembl:ENSMUSG00000000142 AllianceGenome:MGI:1270862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Axi1; Axil; Conductin
    Summary
    Enables I-SMAD binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including heart valve morphogenesis; negative regulation of canonical Wnt signaling pathway; and regulation of centromeric sister chromatid cohesion. Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; and regionalization. Located in centrosome and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study craniosynostosis. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma; gastrointestinal system cancer (multiple); lung cancer (multiple); and orofacial cleft. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 14.6), limb E14.5 (RPKM 12.0) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Axin2 in Genome Data Viewer
    Location:
    11 E1; 11 71.83 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (108808687..108841609)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (108917828..108950783)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 112 Neighboring gene centrosomal protein 112, intronic transcript Neighboring gene predicted gene, 36818 Neighboring gene predicted gene, 46298 Neighboring gene predicted gene, 36876 Neighboring gene predicted gene, 24149

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables I-SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables I-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in aortic valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chondrocyte differentiation involved in endochondral bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal/ventral axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dorsal/ventral axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intramembranous ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of DNA repeat elements IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of DNA repeat elements ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitral valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in odontogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of centromeric sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of centromeric sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of centromeric sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mismatch repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mismatch repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within secondary heart field specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within somitogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of beta-catenin destruction complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    axin-2
    Names
    axin-like protein
    axis inhibition protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417411.1NP_001404340.1  axin-2

      Status: VALIDATED

      Source sequence(s)
      AL662893
      UniProtKB/Swiss-Prot
      O88566, Q6PFZ9, Q9QXJ6
      UniProtKB/TrEMBL
      Q3UQK5
    2. NM_001417412.1NP_001404341.1  axin-2

      Status: VALIDATED

      Source sequence(s)
      AL662893
      UniProtKB/Swiss-Prot
      O88566, Q6PFZ9, Q9QXJ6
      UniProtKB/TrEMBL
      Q3UQK5
    3. NM_001417413.1NP_001404342.1  axin-2

      Status: VALIDATED

      Source sequence(s)
      AL662893
      UniProtKB/Swiss-Prot
      O88566, Q6PFZ9, Q9QXJ6
      UniProtKB/TrEMBL
      Q3UQK5
    4. NM_001417414.1NP_001404343.1  axin-2

      Status: VALIDATED

      Source sequence(s)
      AL662893
      UniProtKB/Swiss-Prot
      O88566, Q6PFZ9, Q9QXJ6
      UniProtKB/TrEMBL
      Q3UQK5
    5. NM_015732.4NP_056547.3  axin-2

      See identical proteins and their annotated locations for NP_056547.3

      Status: VALIDATED

      Source sequence(s)
      AK142333, BC057338
      Consensus CDS
      CCDS25575.1
      UniProtKB/Swiss-Prot
      O88566, Q6PFZ9, Q9QXJ6
      UniProtKB/TrEMBL
      Q3UQK5
      Related
      ENSMUSP00000051331.8, ENSMUST00000052915.14
      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:758840
      DAX; Domain present in Dishevelled and axin
      pfam08833
      Location:432467
      Axin_b-cat_bind; Axin beta-catenin binding domain
      pfam16646
      Location:1073
      AXIN1_TNKS_BD; Axin-1 tankyrase binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      108808687..108841609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532060.3XP_006532123.1  axin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532123.1

      UniProtKB/Swiss-Prot
      O88566, Q6PFZ9, Q9QXJ6
      UniProtKB/TrEMBL
      Q3UQK5
      Related
      ENSMUSP00000102322.2, ENSMUST00000106711.2
      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:758840
      DAX; Domain present in Dishevelled and axin
      pfam08833
      Location:432467
      Axin_b-cat_bind; Axin beta-catenin binding domain
      pfam16646
      Location:1073
      AXIN1_TNKS_BD; Axin-1 tankyrase binding domain