U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pcsk1 proprotein convertase subtilisin/kexin type 1 [ Mus musculus (house mouse) ]

    Gene ID: 18548, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pcsk1provided by MGI
    Official Full Name
    proprotein convertase subtilisin/kexin type 1provided by MGI
    Primary source
    MGI:MGI:97511
    See related
    Ensembl:ENSMUSG00000021587 AllianceGenome:MGI:97511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PC1; PC3; Nec1; SPC3; Nec-1; Phpp-1
    Summary
    Enables identical protein binding activity and serine-type endopeptidase activity. Involved in insulin processing and peptide biosynthetic process. Located in extracellular space. Is active in secretory granule. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; female reproductive system; and nose. Used to study endocrine system disease and obesity. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 4.5), cortex adult (RPKM 4.0) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pcsk1 in Genome Data Viewer
    Location:
    13 C1; 13 40.63 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (75237407..75282980)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (75089420..75134861)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_35028 Neighboring gene STARR-seq mESC enhancer starr_35029 Neighboring gene predicted gene, 30867 Neighboring gene STARR-seq mESC enhancer starr_35030 Neighboring gene STARR-seq mESC enhancer starr_35031 Neighboring gene STARR-seq mESC enhancer starr_35032 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35036 Neighboring gene STARR-seq mESC enhancer starr_35037 Neighboring gene taxilin alpha pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC124320, MGC124321

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in insulin processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pancreas development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptide hormone processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptide hormone processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptide hormone processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pituitary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autoprocessing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to chlorate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neuroendocrine convertase 1
    Names
    furin homolog
    prohormone convertase 1
    prohormone convertase 1/3
    propeptide-processing protease
    NP_001413214.1
    NP_001413216.1
    NP_038656.1
    XP_006517217.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426285.1NP_001413214.1  neuroendocrine convertase 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC158543
      UniProtKB/Swiss-Prot
      P63239
      UniProtKB/TrEMBL
      Q32MU0
    2. NM_001426287.1NP_001413216.1  neuroendocrine convertase 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC158543
      UniProtKB/Swiss-Prot
      P63239
      UniProtKB/TrEMBL
      Q32MU0
    3. NM_013628.3NP_038656.1  neuroendocrine convertase 1 precursor

      See identical proteins and their annotated locations for NP_038656.1

      Status: VALIDATED

      Source sequence(s)
      AC158543
      Consensus CDS
      CCDS26649.1
      UniProtKB/Swiss-Prot
      P63239
      UniProtKB/TrEMBL
      Q32MU0
      Related
      ENSMUSP00000022075.5, ENSMUST00000022075.6
      Conserved Domains (4) summary
      cd04059
      Location:121415
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:504591
      P_proprotein; Proprotein convertase P-domain
      pfam12177
      Location:715751
      Proho_convert; Prohormone convertase enzyme
      pfam16470
      Location:34110
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      75237407..75282980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517154.4XP_006517217.1  neuroendocrine convertase 1 isoform X1

      See identical proteins and their annotated locations for XP_006517217.1

      UniProtKB/Swiss-Prot
      P63239
      UniProtKB/TrEMBL
      Q32MU0
      Conserved Domains (4) summary
      cd04059
      Location:121415
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:504591
      P_proprotein; Proprotein convertase P-domain
      pfam12177
      Location:715751
      Proho_convert; Prohormone convertase enzyme
      pfam16470
      Location:34110
      S8_pro-domain; Peptidase S8 pro-domain