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    Npffr2 neuropeptide FF receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 104443, updated on 3-Dec-2024

    Summary

    Official Symbol
    Npffr2provided by MGI
    Official Full Name
    neuropeptide FF receptor 2provided by MGI
    Primary source
    MGI:MGI:1860130
    See related
    Ensembl:ENSMUSG00000035528 AllianceGenome:MGI:1860130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HG31; Gpr74; NPFF2
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to hormone stimulus. Predicted to be located in actin cytoskeleton. Predicted to be active in plasma membrane. Is expressed in brain; dorsal root ganglion; and trigeminal ganglion. Orthologous to human NPFFR2 (neuropeptide FF receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Npffr2 in Genome Data Viewer
    Location:
    5 E1; 5 44.32 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (89674805..89731473)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (89526840..89583914)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13585 Neighboring gene vitamin D binding protein Neighboring gene predicted gene 6366 Neighboring gene STARR-seq mESC enhancer starr_13586 Neighboring gene predicted gene 7056 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 3 Neighboring gene predicted gene, 42162

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables opioid receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    neuropeptide FF receptor 2
    Names
    G-protein coupled receptor 74
    neuropeptide NPFF receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412387.1NP_001399316.1  neuropeptide FF receptor 2

      Status: VALIDATED

      Source sequence(s)
      AC134840
      UniProtKB/Swiss-Prot
      Q8BKR6, Q924H0
      UniProtKB/TrEMBL
      Q924N0
    2. NM_133192.4NP_573455.2  neuropeptide FF receptor 2

      See identical proteins and their annotated locations for NP_573455.2

      Status: VALIDATED

      Source sequence(s)
      AC134840
      Consensus CDS
      CCDS19408.1
      UniProtKB/Swiss-Prot
      Q8BKR6, Q924H0
      UniProtKB/TrEMBL
      Q924N0
      Related
      ENSMUSP00000040033.3, ENSMUST00000048557.3
      Conserved Domains (2) summary
      cd14964
      Location:4872
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:46343
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      89674805..89731473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)