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    Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 [ Mus musculus (house mouse) ]

    Gene ID: 68349, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndufs3provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S3provided by MGI
    Primary source
    MGI:MGI:1915599
    See related
    Ensembl:ENSMUSG00000005510 AllianceGenome:MGI:1915599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CI-30kD; 0610010M09Rik
    Summary
    Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including alimentary system; ear; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 8. Orthologous to human NDUFS3 (NADH:ubiquinone oxidoreductase core subunit S3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 173.3), kidney adult (RPKM 103.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ndufs3 in Genome Data Viewer
    Location:
    2 E1; 2 50.44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90724971..90735065, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90894627..90904721, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene C1q and tumor necrosis factor related protein 4 Neighboring gene predicted gene, 32514 Neighboring gene predicted gene, 54113 Neighboring gene kelch repeat and BTB (POZ) domain containing 4 Neighboring gene protein tyrosine phosphatase, mitochondrial 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADH dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADH dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
    Names
    NADH-ubiquinone oxidoreductase 30 kDa subunit
    complex I-30kD
    NP_080964.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026688.3NP_080964.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor

      See identical proteins and their annotated locations for NP_080964.1

      Status: VALIDATED

      Source sequence(s)
      AL672241
      Consensus CDS
      CCDS16418.1
      UniProtKB/Swiss-Prot
      Q8BTZ3, Q8R073, Q9DCT2
      Related
      ENSMUSP00000005647.4, ENSMUST00000005647.4
      Conserved Domains (1) summary
      PRK06074
      Location:57239
      PRK06074; NADH dehydrogenase subunit C; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      90724971..90735065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)