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    Slc22a19 solute carrier family 22 (organic anion transporter), member 19 [ Mus musculus (house mouse) ]

    Gene ID: 207151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc22a19provided by MGI
    Official Full Name
    solute carrier family 22 (organic anion transporter), member 19provided by MGI
    Primary source
    MGI:MGI:2442751
    See related
    Ensembl:ENSMUSG00000024757 AllianceGenome:MGI:2442751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oat5; OAT-5; Slc22a9; D630043A20Rik
    Summary
    Enables organic anion transmembrane transporter activity and toxin transmembrane transporter activity. Acts upstream of or within organic anion transport. Predicted to be located in basolateral plasma membrane. Is expressed in metanephros. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A25 (solute carrier family 22 member 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward kidney adult (RPKM 62.4) See more
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    Genomic context

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    See Slc22a19 in Genome Data Viewer
    Location:
    19 A; 19 5.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7650440..7688675, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7673075..7711310, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene phospholipase A and acyltransferase 5 Neighboring gene IscU iron-sulfur cluster scaffold homolog pseudogene Neighboring gene Yamaguchi sarcoma viral (v-yes) oncogene homolog 1 pseudogene Neighboring gene zinc finger protein 280B pseudogene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45471 Neighboring gene solute carrier family 22 (organic cation transporter), member 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel murine organic anion transporter like protein 1 (OATLP1) expressed in the kidney. Jung SM, et al. Exp Mol Med, 2006 Oct 31. PMID 17079864
    2. Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter. Kwak JO, et al. J Steroid Biochem Mol Biol, 2005 Dec. PMID 16150593
    3. Renal expression of organic anion transporter Oat5 in rats and mice exhibits the female-dominant sex differences. Breljak D, et al. Histol Histopathol, 2010 Nov. PMID 20865662
    4. Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Youngblood GL, et al. Am J Physiol Renal Physiol, 2004 Aug. PMID 15068970
    5. Molecular physiology of renal organic anion transporters. Sekine T, et al. Am J Physiol Renal Physiol, 2006 Feb. PMID 16403838

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. renal expression of Oat5 in rats (and mice) exhibits zonal and sex differences
      Title: Renal expression of organic anion transporter Oat5 in rats and mice exhibits the female-dominant sex differences.
    2. mOAT5 has a role in excretion or reabsorption of steroid sulfates in the kidney
      Title: Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter.
    3. Highly expressed in kidney. Motive forces behind Oat5 function, which provide insight into its membrane localization, need to be further resolved.
      Title: Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney.
    4. mOATLP1 appears to be a novel candidate for an organic anion transporter isoform identified in the kidney.
      Title: Identification of a novel murine organic anion transporter like protein 1 (OATLP1) expressed in the kidney.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • MGC29260

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables short-chain fatty acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables toxin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within organic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to molecule of fungal origin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 19
    Names
    organic anion transporter 5
    solute carrier family 22 (organic anion transporter), member 9
    solute carrier family 22 (organic cation transporter), member 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144785.2 → NP_659034.1  solute carrier family 22 member 19

      See identical proteins and their annotated locations for NP_659034.1

      Status: VALIDATED

      Source sequence(s)
      AC109225, AC130693
      Consensus CDS
      CCDS29532.1
      UniProtKB/Swiss-Prot
      Q6A4K9, Q8VCA0
      Related
      ENSMUSP00000025666.8, ENSMUST00000025666.8
      Conserved Domains (1) summary
      cl26863
      Location:11 → 525
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      7650440..7688675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526814.3 → XP_006526877.1  solute carrier family 22 member 19 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:109 → 495
      MFS; Major Facilitator Superfamily

    2. XM_006526815.1 → XP_006526878.1  solute carrier family 22 member 19 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:109 → 429
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCA0.1 GenPept UniProtKB/Swiss-Prot:Q8VCA0

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