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    Ssrp1 structure specific recognition protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 20833, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ssrp1provided by MGI
    Official Full Name
    structure specific recognition protein 1provided by MGI
    Primary source
    MGI:MGI:107912
    See related
    Ensembl:ENSMUSG00000027067 AllianceGenome:MGI:107912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T160; Hmgox; Hmg1-rs1; Hmgi-rs3
    Summary
    Enables chromatin binding activity. Predicted to be involved in nucleosome disassembly and regulation of chromatin organization. Predicted to be located in nucleus. Predicted to be part of FACT complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 88.2), liver E14 (RPKM 67.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ssrp1 in Genome Data Viewer
    Location:
    2 D; 2 49.45 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84867519..84877453)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (85037120..85047114)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39868 Neighboring gene proteoglycan 3 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 3 Neighboring gene STARR-positive B cell enhancer ABC_E225 Neighboring gene tankyrase 1 binding protein 1 Neighboring gene RIKEN cDNA 4930443O20 gene Neighboring gene STARR-seq mESC enhancer starr_05013

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleosome assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in nucleosome disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of FACT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of FACT complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    FACT complex subunit SSRP1
    Names
    facilitates chromatin transcription complex subunit SSRP1
    recombination signal sequence recognition protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136081.3NP_001129553.1  FACT complex subunit SSRP1

      See identical proteins and their annotated locations for NP_001129553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure and differs in the 5' UTR compared to variant 4. All five variants encode the same protein.
      Source sequence(s)
      AL935159, BX546441
      Consensus CDS
      CCDS38165.1
      UniProtKB/Swiss-Prot
      Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
      UniProtKB/TrEMBL
      A2AW05
      Related
      ENSMUSP00000127058.2, ENSMUST00000168266.8
      Conserved Domains (2) summary
      COG5165
      Location:21480
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
      pfam00505
      Location:547614
      HMG_box; HMG (high mobility group) box
    2. NM_001421071.1NP_001408000.1  FACT complex subunit SSRP1

      Status: VALIDATED

      Source sequence(s)
      AL935159, BX546441
      UniProtKB/Swiss-Prot
      Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
      UniProtKB/TrEMBL
      A2AW05
    3. NM_001421072.1NP_001408001.1  FACT complex subunit SSRP1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AL935159, BX546441
      UniProtKB/Swiss-Prot
      Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
      UniProtKB/TrEMBL
      A2AW05
    4. NM_001421073.1NP_001408002.1  FACT complex subunit SSRP1

      Status: VALIDATED

      Source sequence(s)
      AL935159, BX546441
      UniProtKB/Swiss-Prot
      Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
      UniProtKB/TrEMBL
      A2AW05
    5. NM_182990.5NP_892035.2  FACT complex subunit SSRP1

      See identical proteins and their annotated locations for NP_892035.2

      Status: VALIDATED

      Source sequence(s)
      AL935159, BX546441
      Consensus CDS
      CCDS38165.1
      UniProtKB/Swiss-Prot
      Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
      UniProtKB/TrEMBL
      A2AW05
      Related
      ENSMUSP00000076971.7, ENSMUST00000077798.13
      Conserved Domains (2) summary
      COG5165
      Location:21480
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
      pfam00505
      Location:547614
      HMG_box; HMG (high mobility group) box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      84867519..84877453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239405.2XP_011237707.1  FACT complex subunit SSRP1 isoform X2

      Conserved Domains (1) summary
      COG5165
      Location:21436
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]