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    Ulk3 unc-51-like kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 71742, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ulk3provided by MGI
    Official Full Name
    unc-51-like kinase 3provided by MGI
    Primary source
    MGI:MGI:1918992
    See related
    Ensembl:ENSMUSG00000032308 AllianceGenome:MGI:1918992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200015E14Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including fibroblast activation; macroautophagy; and regulation of smoothened signaling pathway. Predicted to be active in autophagosome; cytosol; and phagophore assembly site membrane. Is expressed in cerebral cortex. Orthologous to human ULK3 (unc-51 like kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 7.2), spleen adult (RPKM 6.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ulk3 in Genome Data Viewer
    Location:
    9 B; 9 31.09 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57496423..57503516)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57589141..57596233)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 219, member B Neighboring gene mannose phosphate isomerase Neighboring gene STARR-positive B cell enhancer ABC_E3834 Neighboring gene STARR-positive B cell enhancer ABC_E3835 Neighboring gene secretory carrier membrane protein 2 Neighboring gene complexin 3 Neighboring gene predicted gene, 32392 Neighboring gene lectin, mannose-binding 1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase ULK3
    NP_082171.1
    XP_036011189.1
    XP_036011190.1
    XP_036011191.1
    XP_036011192.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027895.1NP_082171.1  serine/threonine-protein kinase ULK3

      See identical proteins and their annotated locations for NP_082171.1

      Status: VALIDATED

      Source sequence(s)
      AC122528, BC151153, CJ169382, CK023112
      Consensus CDS
      CCDS52809.1
      UniProtKB/Swiss-Prot
      B2RXB9, Q3U3Q1, Q8K1X6, Q9DBR8
      Related
      ENSMUSP00000059947.7, ENSMUST00000053230.7
      Conserved Domains (4) summary
      smart00220
      Location:14270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd02656
      Location:374449
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
      cd02684
      Location:279353
      MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
      cd14121
      Location:18269
      STKc_ULK3; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57496423..57503516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155296.1XP_036011189.1  serine/threonine-protein kinase ULK3 isoform X1

      Conserved Domains (3) summary
      cd02684
      Location:279353
      MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
      cd14121
      Location:18269
      STKc_ULK3; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3
      cl00299
      Location:374425
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    2. XM_036155298.1XP_036011191.1  serine/threonine-protein kinase ULK3 isoform X3

      Conserved Domains (3) summary
      cd02656
      Location:211286
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
      cl00299
      Location:116190
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
      cl21453
      Location:1106
      PKc_like; Protein Kinases, catalytic domain
    3. XM_036155299.1XP_036011192.1  serine/threonine-protein kinase ULK3 isoform X3

      Conserved Domains (3) summary
      cd02656
      Location:211286
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
      cl00299
      Location:116190
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
      cl21453
      Location:1106
      PKc_like; Protein Kinases, catalytic domain
    4. XM_036155297.1XP_036011190.1  serine/threonine-protein kinase ULK3 isoform X2

      Conserved Domains (3) summary
      cd02656
      Location:257332
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
      cd02684
      Location:162236
      MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
      cl21453
      Location:1152
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_379456.5 RNA Sequence

    2. XR_004935557.1 RNA Sequence

    3. XR_379457.5 RNA Sequence

    4. XR_004935560.1 RNA Sequence

    5. XR_004935558.1 RNA Sequence

    6. XR_001779012.3 RNA Sequence

    7. XR_379458.1 RNA Sequence

    8. XR_870767.4 RNA Sequence

    9. XR_379459.2 RNA Sequence