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    Zfp708 zinc finger protein 708 [ Mus musculus (house mouse) ]

    Gene ID: 432769, updated on 27-Nov-2024

    Summary

    Official Symbol
    Zfp708provided by MGI
    Official Full Name
    zinc finger protein 708provided by MGI
    Primary source
    MGI:MGI:3040674
    See related
    Ensembl:ENSMUSG00000058883 AllianceGenome:MGI:3040674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rslcan11
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF28 (zinc finger protein 28); ZNF429 (zinc finger protein 429); and ZNF611 (zinc finger protein 611). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 2.3), CNS E14 (RPKM 2.1) and 22 other tissues See more
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    Genomic context

    See Zfp708 in Genome Data Viewer
    Location:
    13 B3; 13 34.54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67217462..67246040, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67069398..67097976, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene phosphatidylserine synthase 1 Neighboring gene RIKEN cDNA 4933433G19 gene Neighboring gene STARR-seq mESC enhancer starr_34892 Neighboring gene zinc finger protein 712 Neighboring gene STARR-positive B cell enhancer ABC_E3085 Neighboring gene STARR-positive B cell enhancer ABC_E9879 Neighboring gene uncharacterized LOC118568057 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1465 Neighboring gene regulator of sex-limitation candidate 18 Neighboring gene zinc finger protein 759 Neighboring gene STARR-seq mESC enhancer starr_34894 Neighboring gene STARR-positive B cell enhancer ABC_E2411 Neighboring gene regulator of sex limited protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC102251

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 708
    Names
    regulator of sex-limitation candidate 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012325.2NP_001012325.2  zinc finger protein 708 isoform a

      See identical proteins and their annotated locations for NP_001012325.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC089368, CF174027
      UniProtKB/TrEMBL
      F8VPP0
      Related
      ENSMUSP00000105365.4, ENSMUST00000109743.5
      Conserved Domains (5) summary
      smart00349
      Location:1777
      KRAB; krueppel associated box
      COG5048
      Location:119540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1756
      KRAB; KRAB box
      pfam13465
      Location:303328
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001012448.2NP_001012450.2  zinc finger protein 708 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      BB612019, BC089368
      Consensus CDS
      CCDS49298.1
      UniProtKB/TrEMBL
      F2Z422
      Related
      ENSMUSP00000105364.4, ENSMUST00000109742.11
      Conserved Domains (5) summary
      smart00349
      Location:565
      KRAB; krueppel associated box
      COG5048
      Location:107528
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:279299
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:544
      KRAB; KRAB box
      pfam13465
      Location:291316
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001012449.2NP_001012451.2  zinc finger protein 708 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform c).
      Source sequence(s)
      BC089368, CF174027
      Conserved Domains (5) summary
      smart00349
      Location:1762
      KRAB; krueppel associated box
      COG5048
      Location:87508
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1756
      KRAB; KRAB box
      pfam13465
      Location:271296
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001292066.1NP_001278995.1  zinc finger protein 708 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK132353, BC089368
      Consensus CDS
      CCDS79206.1
      UniProtKB/TrEMBL
      A0A087WPV0
      Related
      ENSMUSP00000139928.2, ENSMUST00000190566.3
      Conserved Domains (4) summary
      smart00349
      Location:132
      KRAB; krueppel associated box
      COG5048
      Location:74495
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:246266
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:258283
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67217462..67246040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)