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    Exog exo/endonuclease G [ Mus musculus (house mouse) ]

    Gene ID: 208194, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Exogprovided by MGI
    Official Full Name
    exo/endonuclease Gprovided by MGI
    Primary source
    MGI:MGI:2143333
    See related
    Ensembl:ENSMUSG00000042787 AllianceGenome:MGI:2143333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Engl; Engla; Englb; ENGL-B; ENGL-a; Endogl1; Endogl2
    Summary
    Predicted to enable 5'-3' exonuclease activity; RNA endonuclease activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Located in mitochondrion. Orthologous to human EXOG (exo/endonuclease G). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.0), whole brain E14.5 (RPKM 5.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Exog in Genome Data Viewer
    Location:
    9 F3; 9 71.33 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119274026..119294584)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119444925..119465518)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53515 Neighboring gene activin receptor IIB Neighboring gene STARR-positive B cell enhancer mm9_chr9:119353850-119354151 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119374205-119374506 Neighboring gene STARR-seq mESC enhancer starr_25473 Neighboring gene sodium channel, voltage-gated, type V, alpha Neighboring gene STARR-seq mESC enhancer starr_25474 Neighboring gene sodium channel, voltage-gated, type X, alpha Neighboring gene STARR-seq mESC enhancer starr_25475

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. Szczesny B, et al. Nucleic Acids Res, 2014 Dec 1. PMID 25378300, Free PMC Article
    2. An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Man JCK, et al. Nat Commun, 2019 Oct 30. PMID 31666509, Free PMC Article
    3. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    4. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-3' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclease EXOG, mitochondrial
    Names
    endo G-like 1
    endo/exonuclease (5'-3'), endonuclease G-like
    endonuclease G-like 1
    NP_001397518.1
    NP_001397519.1
    NP_001397520.1
    NP_001397521.1
    NP_001397522.1
    NP_766044.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410589.1 → NP_001397518.1  nuclease EXOG, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121922, AC166052

    2. NM_001410590.1 → NP_001397519.1  nuclease EXOG, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121922, AC166052

    3. NM_001410591.1 → NP_001397520.1  nuclease EXOG, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121922, AC166052

    4. NM_001410592.1 → NP_001397521.1  nuclease EXOG, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121922, AC166052

    5. NM_001410593.1 → NP_001397522.1  nuclease EXOG, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121922, AC166052

    6. NM_172456.4 → NP_766044.1  nuclease EXOG, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_766044.1

      Status: VALIDATED

      Source sequence(s)
      AC121922, AC166052
      Consensus CDS
      CCDS23616.1
      UniProtKB/Swiss-Prot
      Q3UFL2, Q8C163
      Related
      ENSMUSP00000035094.7, ENSMUST00000035094.14
      Conserved Domains (1) summary
      smart00477
      Location:77 → 287
      NUC; DNA/RNA non-specific endonuclease

    RNA

    1. NR_177092.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121922, AC166052

    2. NR_177093.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121922, AC166052

    3. NR_177094.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121922, AC166052

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      119274026..119294584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001172136.1: Suppressed sequence

      Description
      NM_001172136.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C163.1 GenPept UniProtKB/Swiss-Prot:Q8C163

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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