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    Grik4 glutamate receptor, ionotropic, kainate 4 [ Mus musculus (house mouse) ]

    Gene ID: 110637, updated on 9-Dec-2024

    Summary

    Official Symbol
    Grik4provided by MGI
    Official Full Name
    glutamate receptor, ionotropic, kainate 4provided by MGI
    Primary source
    MGI:MGI:95817
    See related
    Ensembl:ENSMUSG00000032017 AllianceGenome:MGI:95817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KA1; KA-1; GluK4; GluRgamma1; 6330551K01Rik
    Summary
    Predicted to enable kainate selective glutamate receptor activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Located in membrane and synapse. Part of kainate selective glutamate receptor complex. Is active in hippocampal mossy fiber to CA3 synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in brain; retina; and spinal cord. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 1.7), frontal lobe adult (RPKM 1.6) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Grik4 in Genome Data Viewer
    Location:
    9 A5.1; 9 23.8 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (42431708..42856296, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (42518182..42945000, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene tectorin alpha Neighboring gene STARR-seq mESC enhancer starr_23902 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:42236216-42236386 Neighboring gene STARR-seq mESC enhancer starr_23903 Neighboring gene predicted gene, 47629 Neighboring gene STARR-seq mESC enhancer starr_23904 Neighboring gene STARR-positive B cell enhancer ABC_E9327 Neighboring gene tubulin folding cofactor E-like Neighboring gene predicted gene 16322 Neighboring gene predicted gene, 36590 Neighboring gene STARR-seq mESC enhancer starr_23909 Neighboring gene STARR-seq mESC enhancer starr_23910 Neighboring gene STARR-seq mESC enhancer starr_23911 Neighboring gene STARR-seq mESC enhancer starr_23914 Neighboring gene predicted gene, 36648 Neighboring gene Rho guanine nucleotide exchange factor 12 Neighboring gene Sp140 nuclear body protein family member pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of kainate selective glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of kainate selective glutamate receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutamate receptor ionotropic, kainate 4
    Names
    glutamate receptor KA-1
    glutamate receptor KA1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175481.6NP_780690.2  glutamate receptor ionotropic, kainate 4 precursor

      See identical proteins and their annotated locations for NP_780690.2

      Status: VALIDATED

      Source sequence(s)
      AC122449, AC136903, AC140387, AC160123
      Consensus CDS
      CCDS23089.1
      UniProtKB/Swiss-Prot
      E9QNA2, Q8BMF5
      UniProtKB/TrEMBL
      Q148R5
      Related
      ENSMUSP00000110515.2, ENSMUST00000114865.8
      Conserved Domains (2) summary
      cd13724
      Location:415785
      PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
      cl10011
      Location:24402
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      42431708..42856296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242383.4XP_011240685.1  glutamate receptor ionotropic, kainate 4 isoform X1

      See identical proteins and their annotated locations for XP_011240685.1

      UniProtKB/Swiss-Prot
      E9QNA2, Q8BMF5
      UniProtKB/TrEMBL
      Q148R5
      Conserved Domains (2) summary
      cd13724
      Location:415785
      PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
      cl10011
      Location:24402
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    2. XM_030244011.2XP_030099871.1  glutamate receptor ionotropic, kainate 4 isoform X1

      UniProtKB/Swiss-Prot
      E9QNA2, Q8BMF5
      UniProtKB/TrEMBL
      Q148R5
      Conserved Domains (2) summary
      cd13724
      Location:415785
      PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
      cl10011
      Location:24402
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    3. XM_030244012.2XP_030099872.1  glutamate receptor ionotropic, kainate 4 isoform X1

      UniProtKB/Swiss-Prot
      E9QNA2, Q8BMF5
      UniProtKB/TrEMBL
      Q148R5
      Conserved Domains (2) summary
      cd13724
      Location:415785
      PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
      cl10011
      Location:24402
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    4. XM_006509941.4XP_006510004.1  glutamate receptor ionotropic, kainate 4 isoform X1

      See identical proteins and their annotated locations for XP_006510004.1

      UniProtKB/Swiss-Prot
      E9QNA2, Q8BMF5
      UniProtKB/TrEMBL
      Q148R5
      Conserved Domains (2) summary
      cd13724
      Location:415785
      PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
      cl10011
      Location:24402
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    5. XM_017313104.3XP_017168593.1  glutamate receptor ionotropic, kainate 4 isoform X6

      Conserved Domains (1) summary
      cd13724
      Location:16386
      PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
    6. XM_036154561.1XP_036010454.1  glutamate receptor ionotropic, kainate 4 isoform X3

      UniProtKB/TrEMBL
      Q148R5
      Conserved Domains (2) summary
      cl10011
      Location:24402
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:425717
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    7. XM_030244015.2XP_030099875.1  glutamate receptor ionotropic, kainate 4 isoform X6

      Conserved Domains (1) summary
      cd13724
      Location:16386
      PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
    8. XM_030244014.2XP_030099874.1  glutamate receptor ionotropic, kainate 4 isoform X6

      Conserved Domains (1) summary
      cd13724
      Location:16386
      PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
    9. XM_006509942.5XP_006510005.1  glutamate receptor ionotropic, kainate 4 isoform X2

      UniProtKB/TrEMBL
      Q148R5
      Conserved Domains (2) summary
      cd13724
      Location:381751
      PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
      cl10011
      Location:1368
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    10. XM_036154562.1XP_036010455.1  glutamate receptor ionotropic, kainate 4 isoform X7

      Conserved Domains (1) summary
      cl21456
      Location:1356
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    11. XM_017313103.3XP_017168592.1  glutamate receptor ionotropic, kainate 4 isoform X4

      Conserved Domains (2) summary
      cd13724
      Location:223593
      PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
      cl10011
      Location:1210
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    12. XM_006509943.4XP_006510006.1  glutamate receptor ionotropic, kainate 4 isoform X5

      Conserved Domains (2) summary
      cd13724
      Location:180550
      PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
      cl10011
      Location:1167
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily