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    Sp6 trans-acting transcription factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 83395, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sp6provided by MGI
    Official Full Name
    trans-acting transcription factor 6provided by MGI
    Primary source
    MGI:MGI:1932575
    See related
    Ensembl:ENSMUSG00000038560 AllianceGenome:MGI:1932575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Epfn; Klf14; 1110025J03Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in epithelial to mesenchymal transition and odontogenesis. Acts upstream of or within regulation of odontogenesis. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including branchial arch; genitourinary system; limb ectoderm; limb epithelium; and tooth. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1K. Orthologous to human SP6 (Sp6 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 4.9), lung adult (RPKM 2.4) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sp6 in Genome Data Viewer
    Location:
    11 D; 11 60.51 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96904395..96915565)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97013569..97024739)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D030028A08 gene Neighboring gene Sp2 transcription factor Neighboring gene STARR-positive B cell enhancer ABC_E11488 Neighboring gene STARR-positive B cell enhancer ABC_E20 Neighboring gene STARR-seq mESC enhancer starr_30576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:96849306-96849459 Neighboring gene predicted gene, 51916 Neighboring gene STARR-positive B cell enhancer ABC_E1429 Neighboring gene STARR-seq mESC enhancer starr_30578 Neighboring gene predicted gene 11532 Neighboring gene secernin 2 Neighboring gene leucine rich repeat containing 46 Neighboring gene predicted gene 11533

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription factor Sp6
    Names
    Kruppel-like factor 14
    Sp6 transcription factor
    epiprofin
    krueppel-like factor 14
    specificity protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363230.1NP_001350159.1  transcription factor Sp6

      Status: VALIDATED

      Source sequence(s)
      AK137686, AL606664
      Consensus CDS
      CCDS25309.1
      UniProtKB/Swiss-Prot
      Q6VM22, Q9ESX2
      UniProtKB/TrEMBL
      A2A708
      Related
      ENSMUSP00000103248.2, ENSMUST00000107622.2
      Conserved Domains (2) summary
      COG5048
      Location:261336
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259278
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_031183.3NP_112460.1  transcription factor Sp6

      See identical proteins and their annotated locations for NP_112460.1

      Status: VALIDATED

      Source sequence(s)
      AK137686, AL606664, BE648643
      Consensus CDS
      CCDS25309.1
      UniProtKB/Swiss-Prot
      Q6VM22, Q9ESX2
      UniProtKB/TrEMBL
      A2A708
      Related
      ENSMUSP00000039307.8, ENSMUST00000047997.8
      Conserved Domains (2) summary
      COG5048
      Location:261336
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259278
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96904395..96915565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)