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    Arhgap29 Rho GTPase activating protein 29 [ Mus musculus (house mouse) ]

    Gene ID: 214137, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arhgap29provided by MGI
    Official Full Name
    Rho GTPase activating protein 29provided by MGI
    Primary source
    MGI:MGI:2443818
    See related
    Ensembl:ENSMUSG00000039831 AllianceGenome:MGI:2443818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Parg1; A830014I19; 6720461J18Rik; B130017I01Rik
    Summary
    Predicted to enable GTPase activator activity and PDZ domain binding activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including 1st branchial arch; alimentary system epithelium; facial prominence; meninges; and skin. Orthologous to human ARHGAP29 (Rho GTPase activating protein 29). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 25.9), subcutaneous fat pad adult (RPKM 19.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Arhgap29 in Genome Data Viewer
    Location:
    3 G1; 3 52.94 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (121746752..121810326)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (121953113..122016677)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34050 Neighboring gene predicted gene, 34119 Neighboring gene predicted gene, 46821 Neighboring gene VISTA enhancer mm435 Neighboring gene ATP-binding cassette, sub-family A member 4 Neighboring gene STARR-positive B cell enhancer ABC_E3466 Neighboring gene predicted gene, 40138 Neighboring gene STARR-seq mESC enhancer starr_08870 Neighboring gene lysine (K)-specific demethylase 4D pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 29
    Names
    PTPL1-associated RhoGAP 1
    rho-type GTPase-activating protein 29

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356524.1NP_001343453.1  rho GTPase-activating protein 29

      Status: VALIDATED

      Source sequence(s)
      AC100183
      Consensus CDS
      CCDS17807.1
      UniProtKB/Swiss-Prot
      Q3V135, Q7TMW2, Q8BLJ2, Q8BLR8, Q8CGF1
      Conserved Domains (3) summary
      smart00109
      Location:614659
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:671883
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:220436
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_172525.3NP_766113.1  rho GTPase-activating protein 29

      See identical proteins and their annotated locations for NP_766113.1

      Status: VALIDATED

      Source sequence(s)
      AC100183
      Consensus CDS
      CCDS17807.1
      UniProtKB/Swiss-Prot
      Q3V135, Q7TMW2, Q8BLJ2, Q8BLR8, Q8CGF1
      Related
      ENSMUSP00000044624.8, ENSMUST00000037958.14
      Conserved Domains (3) summary
      smart00109
      Location:614659
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:671883
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:220436
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      121746752..121810326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501290.3XP_006501353.1  rho GTPase-activating protein 29 isoform X2

      See identical proteins and their annotated locations for XP_006501353.1

      Conserved Domains (3) summary
      smart00109
      Location:550595
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:607819
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:156372
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_006501289.4XP_006501352.1  rho GTPase-activating protein 29 isoform X1

      See identical proteins and their annotated locations for XP_006501352.1

      Conserved Domains (3) summary
      smart00109
      Location:550595
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:607819
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:156372
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature