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    Krt18 keratin 18 [ Mus musculus (house mouse) ]

    Gene ID: 16668, updated on 9-Dec-2024

    Summary

    Official Symbol
    Krt18provided by MGI
    Official Full Name
    keratin 18provided by MGI
    Primary source
    MGI:MGI:96692
    See related
    Ensembl:ENSMUSG00000023043 AllianceGenome:MGI:96692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K18; CK18; Krt1-18
    Summary
    Predicted to enable scaffold protein binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; and tumor necrosis factor-mediated signaling pathway. Located in cell periphery and keratin filament. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study hepatocellular carcinoma and metabolic dysfunction-associated steatohepatitis. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT18 (keratin 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 472.2), bladder adult (RPKM 233.5) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Krt18 in Genome Data Viewer
    Location:
    15 F2; 15 57.22 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101936651..101940461)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102028216..102032026)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36026 Neighboring gene predicted gene, 41404 Neighboring gene predicted gene, 41405 Neighboring gene STARR-seq mESC enhancer starr_39815 Neighboring gene eukaryotic translation initiation factor 4B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intermediate filament ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in keratin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 18
    Names
    cytokeratin endo B
    cytokeratin-18
    keratin D
    keratin complex 1, acidic, gene 18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010664.2NP_034794.2  keratin, type I cytoskeletal 18

      See identical proteins and their annotated locations for NP_034794.2

      Status: VALIDATED

      Source sequence(s)
      AK167469, AW539037, CV561123
      Consensus CDS
      CCDS27869.1
      UniProtKB/Swiss-Prot
      P05784, Q3TIX1, Q3TJH6, Q3TJW7, Q61766
      Related
      ENSMUSP00000023803.7, ENSMUST00000023803.8
      Conserved Domains (1) summary
      pfam00038
      Location:72383
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101936651..101940461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)