U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Adam3 ADAM metallopeptidase domain 3 [ Mus musculus (house mouse) ]

    Gene ID: 11497, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adam3provided by MGI
    Official Full Name
    ADAM metallopeptidase domain 3provided by MGI
    Primary source
    MGI:MGI:102518
    See related
    Ensembl:ENSMUSG00000031553 AllianceGenome:MGI:102518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tMDC; Cyrn1; Taz83
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in fertilization and flagellated sperm motility. Acts upstream of or within several processes, including binding activity of sperm to zona pellucida; positive regulation of gene expression; and regulation of mRNA processing. Located in membrane raft; plasma membrane; and sperm head. Part of protein-containing complex. Is active in cell surface. Human ortholog(s) of this gene implicated in brain glioma and conjunctival squamous cell carcinoma. Orthologous to human ADAM3A (ADAM metallopeptidase domain 3A (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 218.4) See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adam3 in Genome Data Viewer
    Location:
    8 A2; 8 13.09 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25167248..25216393, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (24677232..24726377, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51565 Neighboring gene indoleamine 2,3-dioxygenase 1 Neighboring gene a disintegrin and metallopeptidase domain 18 Neighboring gene predicted gene, 51566 Neighboring gene predicted gene, 26208 Neighboring gene STARR-seq mESC enhancer starr_20948 Neighboring gene a disintegrin and metallopeptidase domain 5 Neighboring gene a disintegrin and metallopeptidase domain 32 Neighboring gene STARR-seq mESC enhancer starr_20951

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    General gene information

    Clone Names

    • MGC150317

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within binding of sperm to zona pellucida IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within single fertilization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm head IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    A disintegrin and metallopeptidase domain 3
    Names
    a disintegrin and metallopeptidase domain 3 (cyritestin)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324489.1NP_001311418.1  A disintegrin and metallopeptidase domain 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138355, BC049609, CJ047279, X64227
      UniProtKB/TrEMBL
      Q62287, Q810R6
      Conserved Domains (4) summary
      smart00608
      Location:289420
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:210285
      Disintegrin
      pfam01421
      Location:1188
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01683
      Location:406455
      EB; EB module
    2. NM_009619.5NP_033749.2  A disintegrin and metallopeptidase domain 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033749.2

      Status: VALIDATED

      Source sequence(s)
      AC138355, BC049609, CJ047279, X64227
      Consensus CDS
      CCDS22196.1
      UniProtKB/Swiss-Prot
      F8VQ03
      UniProtKB/TrEMBL
      Q62287
      Related
      ENSMUSP00000033958.8, ENSMUST00000033958.15
      Conserved Domains (4) summary
      smart00050
      Location:404480
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:483614
      ACR; ADAM Cysteine-Rich Domain
      pfam01562
      Location:27144
      Pep_M12B_propep; Reprolysin family propeptide
      cl26139
      Location:187382
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      25167248..25216393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242113.3XP_011240415.1  A disintegrin and metallopeptidase domain 3 isoform X1

      See identical proteins and their annotated locations for XP_011240415.1

      Conserved Domains (4) summary
      smart00608
      Location:289420
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:210285
      Disintegrin
      pfam01421
      Location:1188
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01683
      Location:406455
      EB; EB module
    2. XM_017312524.2XP_017168013.1  A disintegrin and metallopeptidase domain 3 isoform X1

      Conserved Domains (4) summary
      smart00608
      Location:289420
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:210285
      Disintegrin
      pfam01421
      Location:1188
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01683
      Location:406455
      EB; EB module
    3. XM_011242114.3XP_011240416.1  A disintegrin and metallopeptidase domain 3 isoform X2

      Conserved Domains (3) summary
      pfam00200
      Location:404444
      Disintegrin
      pfam01421
      Location:187382
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:27144
      Pep_M12B_propep; Reprolysin family propeptide