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    Slc16a7 solute carrier family 16 (monocarboxylic acid transporters), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 20503, updated on 3-Dec-2024

    Summary

    Official Symbol
    Slc16a7provided by MGI
    Official Full Name
    solute carrier family 16 (monocarboxylic acid transporters), member 7provided by MGI
    Primary source
    MGI:MGI:1330284
    See related
    Ensembl:ENSMUSG00000020102 AllianceGenome:MGI:1330284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mct2; 4921534N07Rik; 9030411M13Rik; D630004K10Rik
    Summary
    Enables symporter activity. Predicted to be involved in plasma membrane lactate transport and pyruvate transmembrane transport. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; basolateral plasma membrane; and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and nervous system. Orthologous to human SLC16A7 (solute carrier family 16 member 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 38.6), bladder adult (RPKM 5.2) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc16a7 in Genome Data Viewer
    Location:
    10 D3; 10 72.31 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (125055139..125225455, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (125219270..125389586, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28154 Neighboring gene STARR-seq mESC enhancer starr_28155 Neighboring gene predicted gene, 36771 Neighboring gene predicted gene, 46205 Neighboring gene STARR-seq mESC enhancer starr_28157 Neighboring gene STARR-seq mESC enhancer starr_28158 Neighboring gene STARR-seq mESC enhancer starr_28160 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene predicted gene, 40795

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC143699, MGC143700, MGC143718

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables lactate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lactate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lactate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pyruvate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyruvate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in lactate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lactate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in plasma membrane lactate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma membrane lactate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane lactate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyruvate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyruvate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in parallel fiber to Purkinje cell synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    monocarboxylate transporter 2
    Names
    solute carrier family 16 member 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358496.2NP_001345425.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478
      Consensus CDS
      CCDS24218.1
      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Related
      ENSMUSP00000147968.2, ENSMUST00000211781.2
      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1
    2. NM_001358915.2NP_001345844.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478
      Consensus CDS
      CCDS24218.1
      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Related
      ENSMUSP00000100892.3, ENSMUST00000105257.4
      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1
    3. NM_001428806.1NP_001415735.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478, AC153890
      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
    4. NM_001428807.1NP_001415736.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478, AC153890
      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
    5. NM_001428808.1NP_001415737.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478, AC153890
      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
    6. NM_001428809.1NP_001415738.1  monocarboxylate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AC093478, AC153890
      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
    7. NM_011391.3NP_035521.1  monocarboxylate transporter 2

      See identical proteins and their annotated locations for NP_035521.1

      Status: VALIDATED

      Source sequence(s)
      AC093478
      Consensus CDS
      CCDS24218.1
      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Related
      ENSMUSP00000065433.3, ENSMUST00000063318.10
      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      125055139..125225455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513406.4XP_006513469.1  monocarboxylate transporter 2 isoform X1

      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1
    2. XM_030244968.2XP_030100828.1  monocarboxylate transporter 2 isoform X1

      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1
    3. XM_006513413.5XP_006513476.1  monocarboxylate transporter 2 isoform X1

      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1
    4. XM_006513409.5XP_006513472.1  monocarboxylate transporter 2 isoform X1

      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1
    5. XM_006513410.5XP_006513473.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_006513473.1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Related
      ENSMUSP00000147560.2, ENSMUST00000210780.2
      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1
    6. XM_030244969.2XP_030100829.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1
    7. XM_006513408.5XP_006513471.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_006513471.1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1
    8. XM_030244970.2XP_030100830.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1
    9. XM_017313861.3XP_017169350.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      O70451
      UniProtKB/TrEMBL
      Q149G3, Q149G4, Q4FK61
      Conserved Domains (1) summary
      TIGR00892
      Location:5431
      2A0113; monocarboxylate transporter 1