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    Dbndd1 dysbindin domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 72185, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dbndd1provided by MGI
    Official Full Name
    dysbindin domain containing 1provided by MGI
    Primary source
    MGI:MGI:1919435
    See related
    Ensembl:ENSMUSG00000031970 AllianceGenome:MGI:1919435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D8Ertd590e; 2810427I04Rik
    Summary
    Predicted to be involved in regulation of signal transduction. Predicted to be located in cytoplasm. Is expressed in cerebral cortex intermediate zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human DBNDD1 (dysbindin domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 13.4), whole brain E14.5 (RPKM 11.1) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dbndd1 in Genome Data Viewer
    Location:
    8 E1; 8 72.1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124231744..124245535, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123504718..123518277, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39275 Neighboring gene AFG3-like AAA ATPase 1 Neighboring gene STARR-positive B cell enhancer ABC_E6700 Neighboring gene growth arrest specific 8 Neighboring gene nuclear encoded rRNA 5S 100

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Detection of recombinant haplotypes in wild mice (Mus musculus) provides new insights into the origin of Japanese mice. Nunome M, et al. Mol Ecol, 2010 Jun 1. PMID 20465587
    2. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dysbindin domain-containing protein 1
    Names
    dysbindin (dystrobrevin binding protein 1) domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170975.3 → NP_001164446.3  dysbindin domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC158362
      Consensus CDS
      CCDS52702.2
      Related
      ENSMUSP00000135216.3, ENSMUST00000177240.9
      Conserved Domains (1) summary
      pfam04440
      Location:16 → 105
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    2. NM_001170976.2 → NP_001164447.3  dysbindin domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the central coding region and differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC158362
      Consensus CDS
      CCDS52701.2
      UniProtKB/TrEMBL
      H3BIX2
      Related
      ENSMUSP00000134757.3, ENSMUST00000176286.9

    3. NM_001395625.1 → NP_001382554.1  dysbindin domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158362
      Conserved Domains (1) summary
      pfam04440
      Location:46 → 182
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    4. NM_001395626.1 → NP_001382555.1  dysbindin domain-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158362
      Conserved Domains (1) summary
      pfam04440
      Location:1 → 120
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    5. NM_028146.5 → NP_082422.4  dysbindin domain-containing protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). An in-frame AUG is located 29 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is too close to the presumed transcription start site.
      Source sequence(s)
      AC158362
      Consensus CDS
      CCDS22761.3
      UniProtKB/Swiss-Prot
      Q80XJ9, Q8BMU4, Q9CZ00
      UniProtKB/TrEMBL
      H3BKU0
      Related
      ENSMUSP00000135524.3, ENSMUST00000176155.3
      Conserved Domains (1) summary
      pfam04440
      Location:16 → 152
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      124231744..124245535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248510.3 → XP_011246812.1  dysbindin domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam04440
      Location:39 → 175
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    2. XM_011248509.4 → XP_011246811.1  dysbindin domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      PRK13108
      Location:4 → 93
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam04440
      Location:56 → 192
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZ00.1 GenPept UniProtKB/Swiss-Prot:Q9CZ00

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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